About   Help   FAQ
Pikfyve
Gene Detail
 Symbol
Name
ID
Pikfyve
phosphoinositide kinase, FYVE finger containing
MGI:1335106
Synonyms 5230400C17Rik, Pip5k3, PipkIII
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.94 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:65186683-65278695 bp, + strand
From VEGA annotation of GRCm38

  92013 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pikfyve

Human
homologs
Human Homolog PIKFYVE, phosphoinositide kinase, FYVE finger containing
NCBI Gene ID 200576
neXtProt AC  NX_Q9Y2I7
Human Synonyms  CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Human Chr (Location)  2q34; chr2:208266267-208358751 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIKFYVE
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(18) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to implantation with reduced numbers of inner cell mass and trophectoderm cells and blastocoele abnormalities. Mice homozygous for a second null allele show embryonic lethality between somite formation and embryo turning with abnormal visceral endoderm.
 
Phenotype Images(6)
Interactions
Pikfyve interacts with 192 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular protein metabolic process, intracellular signal transduction, ...
Component cell-cell junction, cytoplasmic vesicle, ...
Function 1-phosphatidylinositol-3-phosphate 5-kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (161)    Tissues (146)    Images (16)
Theiler Stages: 17, 22, 23, 27, 28
Assay TypeResults
RNA in situ 160
Northern blot 1
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(56) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000047694 (Evidence)
Ensembl Gene ModelENSMUSG00000025949 (Evidence)
Entrez Gene18711 (Evidence)
UniGene38370
DFCITC1598965, TC1622256, TC1677926, TC1680172, TC1694535
DoTSDT.101217407, DT.101356538, DT.101356539, DT.110906556, DT.110906573, DT.522845
NIA Mouse Gene IndexU000382
EC2.7.1.150
Consensus CDS ProjectCCDS35601.1
International Mouse Knockout Project StatusPikfyve
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047694 VEGA Gene Model | MGI Sequence Detail 92013 C57BL/6J ±  kb
transcript OTTMUST00000122904 VEGA | MGI Sequence Detail 6641 Not Applicable 
polypeptide OTTMUSP00000067278 VEGA | MGI Sequence Detail 2097 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(3)
Polymorphisms SNPs within 2kb(350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002423 Chaperonin Cpn60/TCP-1
InterPro IPR000591 DEP domain
InterPro IPR027409 GroEL-like apical domain
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
InterPro IPR027410 TCP-1-like chaperonin intermediate domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000012747 1-phosphatidylinositol 3-phosphate 5-kinase
References (Earliest) J:51612 Shisheva A, et al., Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol. 1999 Jan;19(1):623-34
(Latest) J:210019 Cai X, et al., PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol. 2014 Apr 1;192(7):3383-9
All references(56)
Other
accession IDs
MGI:1918657

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory