Pikfyve
Gene Detail

Symbol Name ID

Pikfyve phosphoinositide kinase, FYVE finger containing MGI:1335106

Synonyms

5230400C17Rik, Pip5k3, PipkIII

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.94 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:65186750-65274012 bp, + strand From Ensembl annotation of GRCm38   87263 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pikfyve

Human homologs

Human Homolog		PIKFYVE, phosphoinositide kinase, FYVE finger containing
NCBI Gene ID		200576
neXtProt AC		NX_Q9Y2I7
Human Synonyms		CFD, FAB1, PIP5K, PIP5K3, ZFYVE29
Human Chr (Location)		2q34; chr2:209130991-209223475 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PIKFYVE

Alleles and phenotypes

All alleles(23) : Targeted(5) Gene trapped(18)
 

Mice homozygous for a null allele die prior to implantation with reduced numbers of inner cell mass and trophectoderm cells and blastocoele abnormalities. Mice homozygous for a second null allele show embryonic lethality between somite formation and embryo turning with abnormal visceral endoderm.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cellular protein metabolic process, intracellular signal transduction, ...
Component	cytoplasmic vesicle, cytosol, ...
Function	1-phosphatidylinositol-3-phosphate 5-kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (161)    Tissues (145)    Images (16)
Theiler Stages: 17, 22, 23, 28

Assay Type	Results
RNA in situ	160
Northern blot	1

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) cDNA(55) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000025949 (Evidence)
Entrez Gene	18711 (Evidence)
UniGene	38370
DFCI	TC1598965, TC1622256, TC1677926, TC1680172, TC1694535
DoTS	DT.101217407, DT.101356538, DT.101356539, DT.110906556, DT.110906573, DT.522845
NIA Mouse Gene Index	U000382
EC	2.7.1.150
Consensus CDS Project	CCDS35601.1
International Mouse Knockout Project Status	Pikfyve

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025949	Ensembl Gene Model | MGI Sequence Detail	87263	C57BL/6J
transcript	ENSMUST00000097707	Ensembl | MGI Sequence Detail	6641	Not Applicable
polypeptide	ENSMUSP00000095314	Ensembl | MGI Sequence Detail	2097	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(281 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002423	Chaperonin Cpn60/TCP-1
InterPro	IPR000591	DEP domain
InterPro	IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro	IPR016034	Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000012747	FYVE finger-containing phosphoinositide kinase

References

(Earliest) J:51612 Shisheva A, et al., Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol. 1999 Jan;19(1):623-34
(Latest) J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
All references(51)

Other accession IDs

MGI:1918657