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Lig4
Gene Detail
 Symbol
Name
ID
Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098
Synonyms 5830471N16Rik, DNA ligase IV, tiny
Feature Type protein coding gene
Genetic Map
Chromosome 8
4.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:9970020-9976323 bp, - strand
From NCBI annotation of GRCm38

  6304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1736  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lig4

Human
homologs
Human Homolog LIG4, ligase IV, DNA, ATP-dependent
NCBI Gene ID 3981
neXtProt AC  NX_P49917
Human Chr (Location)  13q33-q34; chr13:108207442-108218368 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human LIG4
Alleles
and
phenotypes
All alleles(11) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygotes die late in gestation with extensive CNS apoptosis, blocked lymphopoeiesis and failure of V(D)J joining. Carrier fibroblasts show elevated chromosome breaks. ~40% of homozygous hypomorphs survive, with retarded growth, reduced PBL and progressive loss of hematopoietic stem cells.
 
Human Diseases Modeled Using Mouse Lig4 (1)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process cell cycle, cell division, ...
Component chromosome, condensed chromosome, ...
Function ATP binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (97)    Tissues (96)   
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) Genomic(1) cDNA(33) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000049717 (Evidence)
Entrez Gene319583 (Evidence)
UniGene80584
DFCITC1583831, TC1608504, TC1677445
DoTSDT.101726060, DT.525997
NIA Mouse Gene IndexU029574
EC6.5.1.1
Consensus CDS ProjectCCDS22092.1
International Mouse Knockout Project StatusLig4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 319583 NCBI Gene Model | MGI Sequence Detail 6304 C57BL/6J ±  kb
transcript NM_176953 RefSeq | MGI Sequence Detail 4081 C57BL/6 
polypeptide Q8BTF7 UniProt | EBI | MGI Sequence Detail 911 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR000977 DNA ligase, ATP-dependent
InterPro IPR012310 DNA ligase, ATP-dependent, central
InterPro IPR016059 DNA ligase, ATP-dependent, conserved site
InterPro IPR012309 DNA ligase, ATP-dependent, C-terminal
InterPro IPR012308 DNA ligase, ATP-dependent, N-terminal
InterPro IPR021536 DNA ligase IV
InterPro IPR012340 Nucleic acid-binding, OB-fold
Protein Ontology PR:000009802 DNA ligase 4
Graphical View of Protein Domain Structure
References (Earliest) J:50865 Frank KM, et al., Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12;396(6707):173-7
(Latest) J:204283 Rommel PC, et al., Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development. PLoS One. 2013;8(7):e69208
All references(89)
Other
accession IDs
MGI:2442329, MGI:3584400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory