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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Atmtm1Pmc/\Atm+
\Lig4tm1Icrf/\Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
\Atmtm1Pmc/\Atmtm1Pmc
\Lig4tm1Icrf/\Lig4+
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
\Atmtm1Pmc/\Atmtm1Pmc
\Lig4tm1Icrf/\Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		decreased body size J:65540
decreased neuron apoptosis J:65540, J:111068
neonatal lethality, complete penetrance J:65540, J:111068
\Atmtm1Pmc/\Atmtm1Pmc
\Lig4tm1Icrf/\Lig4tm1Icrf
involves: 129 		decreased cellular sensitivity to ionizing radiation J:144172
perinatal lethality J:144172
\Atmtm1Pmc/\Atmtm1Pmc
\Lig4tm1Pmc/\Lig4tm1Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
\Cdkn2atm1Rdp/\Cdkn2a+
\Lig4tm1Fwa/\Lig4tm1Fwa
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		decreased cell proliferation J:63078
increased cellular sensitivity to ionizing radiation J:63078
increased neuron apoptosis J:63078
prenatal lethality, complete penetrance J:63078
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp
\Lig4tm1Fwa/\Lig4tm1Fwa
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		decreased cell proliferation J:63078
prenatal lethality, complete penetrance J:63078
\Ightm2Cgn/\Ightm2Cgn
\Igktm1Rsky/\Igktm1Rsky
\Lig4tm1Fwa/\Lig4tm1Fwa
\Trp53tm1Tyj/\Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal class switch recombination J:126758
\Lig4tm1Fwa/\Lig4tm1Fwa
\Tg(Cr2-cre)3Cgn/0
\Xrcc4tm2Fwa/\Xrcc4tm2Fwa
involves: 129S6/SvEvTac 		abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
\Lig4tm1Fwa/\Lig4tm1Fwa
\Trp53tm1Brd/\Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		decreased body weight J:63078
decreased neuron apoptosis J:63078
premature death J:63078
prenatal lethality, incomplete penetrance J:63078
\Lig4tm1Fwa/\Lig4tm1Fwa
\Trp53tm1Brd/\Trp53tm1Brd
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		decreased body weight J:63078
decreased neuron apoptosis J:63078
decreased thymocyte number J:63078
increased B cell number J:63078
increased cellular sensitivity to ionizing radiation J:63078
increased fibroblast proliferation J:63078
increased lymphoma incidence J:63078
premature death J:63078
prenatal lethality, incomplete penetrance J:63078
\Lig4tm1Icrf/\Lig4tm1Icrf
\Mre11atm1Jpt/\Mre11atm1Jpt
involves: 129 * 129S7/SvEvBrd 		decreased cellular sensitivity to ionizing radiation J:144172
neonatal lethality, complete penetrance J:144172
\Lig4tm1Icrf/\Lig4tm1Icrf
\Nbntm1Jpt/\Nbntm1Jpt
involves: 129 * 129S7/SvEvBrd 		normal cellular phenotype J:144172
prenatal lethality, complete penetrance J:144172
\Lig4tm1Icrf/\Lig4tm1Icrf
\Nbntm2.1Jpt/\Nbntm2.1Jpt
involves: 129 		perinatal lethality, complete penetrance J:144172
\Lig4tm1Icrf/\Lig4tm1Icrf
\Trp53tm1Tyj/\Trp53+
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) 		decreased tumor incidence J:111068
perinatal lethality, incomplete penetrance J:111068
premature death J:111068
\Lig4tm1Icrf/\Lig4tm1Icrf
\Trp53tm1Tyj/\Trp53tm1Tyj
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) 		increased B cell derived lymphoma incidence J:111068
increased medulloblastoma incidence J:111068
\Lig4tm1Pmc/\Lig4tm1Pmc
\Mre11atm1Jpt/\Mre11atm1Jpt
\Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
\Lig4tm1Pmc/\Lig4tm1Pmc
\Nbntm1Jpt/\Nbntm1Jpt
\Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal brain development J:144172
decreased brain weight J:144172
microcephaly J:144172
\Lig4tm1Pmc/\Lig4tm1Pmc
\Trp53tm1Tyj/\Trp53+
\Xrcc2tm2Pmc/\Xrcc2tm2Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		abnormal tumor morphology J:144617
increased medulloblastoma incidence J:144617
premature death J:144617
\Lig4tm1Pmc/\Lig4tm1Pmc
\Trp53tm1Tyj/\Trp53tm1Tyj
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
\Lig4tm1Pmc/\Lig4tm1Pmc
\Trp53tm1Tyj/\Trp53tm1Tyj
\Xrcc2tm2Pmc/\Xrcc2tm2Pmc
\Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
\Paxxem1Spj/\Paxxem1Spj
\Lig4tm1Fwa/\Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		prenatal lethality, complete penetrance J:236776
\Xrcc5tm1Dbr/\Xrcc5+
\Lig4tm1Fwa/\Lig4+
involves: 129S6/SvEvTac * C57BL/6 		chromosome breakage J:80467
\Xrcc5tm1Dbr/\Xrcc5tm1Dbr
\Lig4tm1Fwa/\Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 		abnormal lymphocyte morphology J:80467
abnormal small intestine morphology J:80467
chromosome breakage J:80467
normal mortality/aging J:80467
prenatal lethality, incomplete penetrance J:80467
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory