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Atmtm1Pmc
Targeted Allele Detail
Summary
Symbol: Atmtm1Pmc
Name: ataxia telangiectasia mutated; targeted mutation 1, Peter J McKinnon
MGI ID: MGI:1933746
Synonyms: Atm-
Gene: Atm  Location: Chr9:53350449-53448040 bp, - strand  Genetic Position: Chr9, 29.12 cM, cytoband C-D
Alliance: Atmtm1Pmc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47752
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin gene interrupts exon 57 and replaces exon 58. This region corresponds to a region deleted in some human AT deficiency cases. (J:47752)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atm Mutation:  126 strains or lines available
References
Original:  J:47752 Herzog KH, et al., Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science. 1998 May 15;280(5366):1089-91
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory