94 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lig4m1Btlr/Lig4m1Btlr C57BL/6J-Lig4m1Btlr	decreased B cell number	J:267684
	decreased CD4-positive, alpha-beta T cell number	J:267684
	decreased CD8-positive, naive alpha-beta T cell number	J:267684
	decreased IgD level	J:267684
	decreased IgG level	J:267684
	impaired humoral immune response	J:267684
	increased CD8-positive, alpha-beta T cell number	J:267684
	increased central memory CD8 positive, alpha-beta T cell number	J:267684
	increased effector memory CD4-positive, alpha-beta T cell number	J:267684
	increased NK cell number	J:267684
Lig4m2Btlr/Lig4m2Btlr C57BL/6J-Lig4m2Btlr	decreased CD4-positive, alpha-beta T cell number	J:267692
	increased effector memory CD4-positive, alpha-beta T cell number	J:267692
Lig4tiny/Lig4tiny C57BL/6-Lig4tiny	abnormal DNA repair	J:122725
	abnormal proerythroblast morphology	J:122725
	absent CD8-positive, alpha-beta T cells	J:104190
	decreased B cell number	J:122725
	decreased body size	J:122725
	decreased bone marrow cell number	J:122725
	decreased fibroblast proliferation	J:122725
	decreased hematopoietic stem cell number	J:122725
	decreased lymphocyte cell number	J:122725
	postnatal growth retardation	J:122725
	prenatal lethality, incomplete penetrance	J:122725
Lig4tm1Fwa/Lig4+ involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
Lig4tm1Fwa/Lig4tm1Fwa involves: 129S6/SvEvTac	abnormal brainstem morphology	J:110848
	abnormal cell physiology	J:110848
	abnormal diencephalon morphology	J:110848
	abnormal striatum morphology	J:110848
	chromosomal instability	J:147247
	increased cellular sensitivity to ionizing radiation	J:147247
	increased forebrain apoptosis	J:110848
	increased spinal cord apoptosis	J:110848
	induced chromosome breakage	J:147247
	thin cerebral cortex	J:110848
Lig4tm1Fwa/Lig4tm1Fwa involves: 129S6/SvEvTac * C57BL/6	abnormal B cell differentiation	J:50865
	abnormal cell physiology	J:50865
	abnormal lymphopoiesis	J:50865
	abnormal T cell differentiation	J:63078
	arrested B cell differentiation	J:63078
	arrested T cell differentiation	J:50865
	chromosome breakage	J:80467
	decreased cell proliferation	J:50865
	decreased fetal size	J:50865
	decreased thymocyte number	J:63078
	normal hematopoietic system phenotype	J:50865
	increased cellular sensitivity to gamma-irradiation	J:50865
	lethality throughout fetal growth and development, incomplete penetrance	J:50865
	prenatal lethality, complete penetrance	J:80467
	small thymus	J:50865
Lig4tm1Icrf/Lig4tm1Icrf either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	increased neuron apoptosis	J:51608, J:65540, J:111068
	lethality throughout fetal growth and development, complete penetrance	J:51608
Lig4tm1Icrf/Lig4tm1Icrf involves: 129	normal cellular phenotype	J:144172
Lig4tm1Pmc/Lig4tm1Pmc Meox2tm1(cre)Sor/Meox2+ involves: 129S1/Sv * 129S4/SvJaeSor	abnormal nervous system development	J:144617
Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	abnormal double-strand DNA break repair	J:226703
	normal nervous system phenotype	J:144617
Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/SvImJ * C57BL/6 * SJL	abnormal brain development	J:144172
	abnormal DNA repair	J:144172
	ataxia	J:144172
	decreased brain size	J:144172
	decreased brain weight	J:144172
	microcephaly	J:144172
Lig4tm2.1Fwa/Lig4tm2.1Fwa involves: 129S6/SvEvTac	abnormal B cell activation	J:157574
	abnormal B cell differentiation	J:157574
	abnormal cell physiology	J:157574
	abnormal immune system cell morphology	J:157574
	abnormal immune system morphology	J:157574
	abnormal immune system organ morphology	J:157574
	abnormal immune system physiology	J:157574
	abnormal lymphocyte cell number	J:157574
	abnormal regulatory T cell morphology	J:157574
	abnormal T cell activation	J:157574
	abnormal T cell differentiation	J:157574
	abnormal T cell receptor beta chain V(D)J recombination	J:157574
	abnormal T cell receptor V(D)J recombination	J:157574
	abnormal thymus morphology	J:157574
	chromosomal instability	J:157574
	decreased B cell number	J:157574
	decreased body size	J:157574
	decreased body weight	J:157574
	decreased CD4-positive, alpha-beta T cell number	J:157574
	decreased CD8-positive, alpha-beta T cell number	J:157574
	decreased double-negative T cell number	J:157574
	decreased double-positive T cell number	J:157574
	decreased IgA level	J:157574
	decreased IgG2b level	J:157574
	decreased IgG3 level	J:157574
	decreased IgG level	J:157574
	decreased IgM level	J:157574
	decreased immunoglobulin level	J:157574
	decreased interferon-gamma secretion	J:157574
	decreased interleukin-13 secretion	J:157574
	decreased spleen weight	J:157574
	decreased splenocyte number	J:157574
	decreased T cell proliferation	J:157574
	decreased thymocyte number	J:157574
	decreased thymus weight	J:157574
	increased anti-chromatin antibody level	J:157574
	increased anti-double stranded DNA antibody level	J:157574
	increased cellular sensitivity to gamma-irradiation	J:157574
	increased colon adenocarcinoma incidence	J:157574
	increased medulloblastoma incidence	J:157574
	increased T cell apoptosis	J:157574
	increased T cell derived lymphoma incidence	J:157574
	intestinal inflammation	J:157574
	liver inflammation	J:157574
	postnatal growth retardation	J:157574
	premature death	J:157574
	reduced fertility	J:157574
	small spleen	J:157574
	small thymus	J:157574
	spontaneous chromosome breakage	J:157574
Lig4tm3.1Fwa/Lig4tm3.1Fwa Tg(Cr2-cre)3Cgn/0 Not Specified	abnormal class switch recombination	J:157537