Lig4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lig4^m1Btlr
• Name: ligase IV, DNA, ATP-dependent; mutation 1, Bruce Beutler
• MGI ID: MGI:6269393
• Synonyms: posey
• Gene: Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
• Alliance: Lig4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 9,972,955 (v38) on chromosome 8, or base pair 4,711 in the GenBank genomic region NC_000074 encoding Lig4. The mutation corresponds to residue 1,146 in the mRNA sequence NM_176953 within exon 2 of 2 total exons. The mutation results in an aspartic acid (D) to glycine (G) substitution at amino acid 275 (D275G) in the LIG4 protein. (J:267684)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig4 Mutation: 44 strains or lines available

References

• Original: J:267684 Zhong X, et al., Mutagenetix entry for posey. MGI Direct Data Submission. 2018
• All: 1 reference(s)