Lig4^tm3.1Fwa
Targeted Allele Detail

Summary

• Symbol: Lig4^tm3.1Fwa
• Name: ligase IV, DNA, ATP-dependent; targeted mutation 3.1, Frederick W Alt
• MGI ID: MGI:4437900
• Synonyms: Lig4^c
• Gene: Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
• Alliance: Lig4^tm3.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157537
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding region and a floxed neo cassette was inserted downstream. Cre mediated recombination removed the neo cassette leaving the coding region floxed. (J:157537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig4 Mutation: 44 strains or lines available

References

• Original: J:157537 Boboila C, et al., Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9
• All: 2 reference(s)