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Symbol Name ID |
Lig4
ligase IV, DNA, ATP-dependent MGI:1335098 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
| Disease(s) Associated with LIG4 | ||||
| multiple myeloma |
| Mouse Phenotypes | cellular phenotype |
abnormal cell physiology |
increased cellular sensitivity to ionizing radiation |
increased cellular sensitivity to gamma-irradiation |
increased T cell apoptosis |
increased neuron apoptosis |
increased forebrain apoptosis |
increased spinal cord apoptosis |
decreased T cell proliferation |
decreased fibroblast proliferation |
decreased cell proliferation |
abnormal DNA repair |
abnormal double-strand DNA break repair |
chromosomal instability |
chromosome breakage |
induced chromosome breakage |
spontaneous chromosome breakage |
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| Availability | Mouse Genotype | |||||||||||||||||
| Lig4tiny/Lig4tiny | ||||||||||||||||||
| Lig4tm1Fwa/Lig4tm1Fwa | ||||||||||||||||||
| Lig4tm1Icrf/Lig4tm1Icrf | * | |||||||||||||||||
| Lig4tm2.1Fwa/Lig4tm2.1Fwa | ||||||||||||||||||
| Lig4tm1Fwa/Lig4+ | ||||||||||||||||||
| Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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