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Zfpm2
Gene Detail
Symbol

Name
ID
Zfpm2
zinc finger protein, multitype 2
MGI:1334444
Synonyms
B330005D23Rik, FOG2, FOG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:40655042-41104592 bp, + strand
From NCBI annotation of GRCm38

  449551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZFPM2
Gene Tree: Zfpm2

Human
homologs
ZFPM2, zinc finger protein, FOG family member 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23414
neXtProt AC: NX_Q8WW38

Human Synonyms: DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B

Human Chr (Location): 8q23; chr8:105246436-105804539 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ZFPM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
 
Human Diseases Modeled in Mice Using Zfpm2 (3)    Mutations Annotated to Human Diseases (3)    Phenotype Images(2)
Interactions
Zfpm2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process atrioventricular valve morphogenesis, cardiac muscle tissue development, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (187)    Tissues (78)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 10
RT-PCR 74
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN zfpm2a, zfpm2b    NEW 
Molecular
reagents
All nucleic(36) cDNA(28) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022306 (Evidence)
Entrez Gene 22762 (Evidence)
UniGene 39496
DFCI TC1581986, TC1596889, TC1615304
DoTS DT.91555346, DT.87031450, DT.40169898, DT.102537755
NIA Mouse Gene Index U097362
Consensus CDS Project CCDS27447.1
International Mouse Phenotyping Consortium Status Zfpm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ±  kb
transcript NM_011766 RefSeq | MGI Sequence Detail 4974 C57BL/6 
polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(3989 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017653 zinc finger protein ZFPM2
Graphical View of Protein Domain Structure
References
(Earliest) J:52532 Tevosian SG, et al., FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5
(Latest) J:216295 Garnatz AS, et al., FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 1;395(1):50-61
All references(92)
Disease annotation references (4)
Other
accession IDs
MGI:2444606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory