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Zfpm2
Gene Detail
 Symbol
Name
ID
Zfpm2
zinc finger protein, multitype 2
MGI:1334444
Synonyms B330005D23Rik, FOG2, FOG-2
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:40655042-41104592 bp, + strand
From NCBI annotation of GRCm38

  449551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfpm2

Human
homologs
Human Homolog ZFPM2, zinc finger protein, FOG family member 2
NCBI Gene ID 23414
neXtProt AC  NX_Q8WW38
Human Synonyms  DIH3, FOG2, hFOG-2, ZC2HC11B, ZNF89B
Human Chr (Location)  8q23; chr8:105318690-105804539 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ZFPM2
Alleles
and
phenotypes
All alleles(8) : Targeted(6) Gene trapped(1) Chemically induced(1)
 
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
 
Human Diseases Modeled Using Mouse Zfpm2 (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process atrioventricular valve morphogenesis, cardiac muscle tissue development, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (187)    Tissues (72)    Images (33)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 103
Northern blot 10
RT-PCR 74
cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) cDNA(28) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022306 (Evidence)
Entrez Gene22762 (Evidence)
UniGene39496
DFCITC1581986, TC1596889, TC1615304
DoTSDT.102537755, DT.40169898, DT.87031450, DT.91555346
NIA Mouse Gene IndexU097362
Consensus CDS ProjectCCDS27447.1
International Mouse Knockout Project StatusZfpm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ±  kb
transcript NM_011766 RefSeq | MGI Sequence Detail 4974 C57BL/6 
polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(3989 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017653 zinc finger protein ZFPM2
Graphical View of Protein Domain Structure
References (Earliest) J:52532 Tevosian SG, et al., FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5
(Latest) J:204550 Fujimoto Y, et al., Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
All references(88)
Other
accession IDs
MGI:2444606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory