Zfpm2
Gene Detail

Symbol Name ID

Zfpm2 zinc finger protein, multitype 2 MGI:1334444

Synonyms

B330005D23Rik, FOG2, FOG-2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

15.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:40655042-41104592 bp, + strand From NCBI annotation of GRCm38   449551 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfpm2

Human homologs

Human Homolog		ZFPM2, zinc finger protein, FOG family member 2
NCBI Gene ID		23414
neXtProt AC		NX_Q8WW38
Human Synonyms		DIH3, FOG2, hFOG-2, ZC2HC11B, ZNF89B
Human Chr (Location)		8q23; chr8:106331147-106816767 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ZFPM2

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(1) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.

 
Human Diseases Modeled Using Mouse Zfpm2 (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	atrioventricular valve morphogenesis, cardiac muscle tissue development, ...
Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (185)    Tissues (70)    Images (33)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	101
Northern blot	10
RT-PCR	74

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(27) Primer pair(5) Other(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022306 (Evidence)
Entrez Gene	22762 (Evidence)
UniGene	39496
DFCI	TC1581986, TC1596889, TC1615304
DoTS	DT.102537755, DT.40169898, DT.87031450, DT.91555346
NIA Mouse Gene Index	U097362
Consensus CDS Project	CCDS27447.1
International Mouse Knockout Project Status	Zfpm2

Sequences

Length	Strain/Species
genomic	22762	NCBI Gene Model | MGI Sequence Detail	449551	C57BL/6J
transcript	NM_011766	RefSeq | MGI Sequence Detail	4974	C57BL/6
polypeptide	Q8CCH7	UniProt | EBI | MGI Sequence Detail	1151	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(2433 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017653	zinc finger protein ZFPM2

Graphical View of Protein Domain Structure

References

(Earliest) J:52532 Tevosian SG, et al., FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5
(Latest) J:189064 Chassot AA, et al., WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012 Dec;139(23):4461-72
All references(85)

Other accession IDs

MGI:2444606