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Zfpm2 Gene Detail
Summary
  • Symbol
    Zfpm2
  • Name
    zinc finger protein, multitype 2
  • Synonyms
    B330005D23Rik, FOG2, FOG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334444
    NCBI Gene: 22762
  • Gene Overview
    MyGene.info: ZFPM2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:40655035-41104592 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.74 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3984 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334444
protein coding gene Chr15:40654884-41104592 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021820
protein coding gene Chr15:39124620-39602716 (+)
A/J MGP_AJ_G0021780
protein coding gene Chr15:37620007-38070741 (+)
AKR/J MGP_AKRJ_G0021761
protein coding gene Chr15:38744519-39198065 (+)
BALB/cJ MGP_BALBcJ_G0021787
protein coding gene Chr15:37676024-38150056 (+)
C3H/HeJ MGP_C3HHeJ_G0021561
protein coding gene Chr15:38636517-39107706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022226
protein coding gene Chr15:40632589-41135156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019763
protein coding gene Chr15:35331741-35769613 (+)
CAST/EiJ MGP_CASTEiJ_G0021078
protein coding gene Chr15:39132369-39605568 (+)
CBA/J MGP_CBAJ_G0021530
protein coding gene Chr15:42040808-42547246 (+)
DBA/2J MGP_DBA2J_G0021654
protein coding gene Chr15:37456888-37910454 (+)
FVB/NJ MGP_FVBNJ_G0021632
protein coding gene Chr15:36819702-37257882 (+)
LP/J MGP_LPJ_G0021724
protein coding gene Chr15:38934991-39399784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021656
protein coding gene Chr15:45035331-45547598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022249
protein coding gene Chr15:38904027-39385997 (+)
PWK/PhJ MGP_PWKPhJ_G0020823
protein coding gene Chr15:37507097-37959012 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020660
protein coding gene Chr15:38544823-39018841 (+)
WSB/EiJ MGP_WSBEiJ_G0021133
protein coding gene Chr15:38813935-39283603 (+)



Homology
more
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B
  • Links
    NCBI Gene ID: 23414
    neXtProt AC: NX_Q8WW38
    UniProt: Q8WW38

  • Chr Location
    8q23.1; chr8:105318859-105804539 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8008
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZFPM2
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Zfpm2 mouse models; 3 with human ZFPM2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 7 alleles in 13 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022306 Ensembl Gene Model | MGI Sequence Detail 449558 C57BL/6J ±  kb
    transcript ENSMUST00000053467 Ensembl | MGI Sequence Detail 4981 Not Applicable  
    polypeptide ENSMUSP00000051335 Ensembl | MGI Sequence Detail 1151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 29
      Primer pair 6
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444606
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 62
      Diseases 4
      Gene Ontology 21
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:255915 Goupille O, et al., The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis. Cell Rep. 2017 Dec 19;21(12):3524-3535

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory