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Zfpm2 Gene Detail
Summary
  • Symbol
    Zfpm2
  • Name
    zinc finger protein, multitype 2
  • Synonyms
    B330005D23Rik, FOG2, FOG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334444
    NCBI Gene: 22762
  • Gene Overview
    MyGene.info: ZFPM2
Location & Maps
more
  • Sequence Map
    Chr15:40655042-41104592 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      449551 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.74 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B
  • Links
    NCBI Gene ID: 23414
    neXtProt AC: NX_Q8WW38

  • Chr Location
    8q23; chr8:105246436-105804539 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8008
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ZFPM2
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Zfpm2 mouse models; 3 with human ZFPM2 associations

Human Disease Mouse Models
       Tetralogy of Fallot; TOF   OMIM: 187500 View 1 model
       Diaphragmatic Hernia, Congenital   OMIM: 142340 View 1 model
Tricuspid Atresia   OMIM: 605067 View 1 model
       46,xy Sex Reversal 9; SRXY9   OMIM: 616067
Diaphragmatic Hernia 3; DIH3   OMIM: 610187
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 7 alleles in 13 genetic backgrounds
    21 phenotypes from multigenic genotypes
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    2 involving Zfpm2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ±  kb
transcript NM_011766 RefSeq | MGI Sequence Detail 4974 C57BL/6  
polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3984 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017653 zinc finger protein ZFPM2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 36
    cDNA 28
    Primer pair 5
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2444606
References
more
  • Summaries
    All 93
    Developmental Gene Expression 51
    Diseases 4
    Gene Ontology 20
    Phenotypes 25
  • Earliest
    J:52532 Tevosian SG, et al., FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5
  • Latest
    J:227426 Wiegreffe C, et al., Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c. Neuron. 2015 Jul 15;87(2):311-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory