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Zfpm2 Gene Detail
Summary
  • Symbol
    Zfpm2
  • Name
    zinc finger protein, multitype 2
  • Synonyms
    B330005D23Rik, FOG2, FOG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334444
    NCBI Gene: 22762
  • Gene Overview
    MyGene.info: ZFPM2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:40655035-41104592 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      449558 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.74 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFPM2, zinc finger protein, FOG family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B
  • Links
    NCBI Gene ID: 23414
    neXtProt AC: NX_Q8WW38
    UniProt: Q8WW38

  • Chr Location
    8q23.1; chr8:105318859-105804539 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8008
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZFPM2
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Zfpm2 mouse models; 3 with human ZFPM2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 7 alleles in 13 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022306 Ensembl Gene Model | MGI Sequence Detail 449558 C57BL/6J ±  kb
    transcript ENSMUST00000053467 Ensembl | MGI Sequence Detail 4981 Not Applicable  
    polypeptide ENSMUSP00000051335 Ensembl | MGI Sequence Detail 1151 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3984 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 29
      Primer pair 6
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444606
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 62
      Diseases 4
      Gene Ontology 20
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:251389 Zakariyah AF, et al., Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit. J Mol Cell Cardiol. 2017 Apr;105:89-98

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory