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Zfpm2
Gene Detail
Symbol

Name
ID
Zfpm2
zinc finger protein, multitype 2
MGI:1334444
Synonyms
B330005D23Rik, FOG2, FOG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:40655042-41104592 bp, + strand
From NCBI annotation of GRCm38

  449551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfpm2

Human
homologs
Human Homolog ZFPM2, zinc finger protein, FOG family member 2
NCBI Gene ID 23414
neXtProt AC  NX_Q8WW38
Human Synonyms  DIH3, FOG2, hFOG-2, SRXY9, ZC2HC11B, ZNF89B
Human Chr (Location)  8q23; chr8:105318690-105804539 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human ZFPM2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.
 
Human Diseases Modeled Using Mouse Zfpm2 (3)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Interactions
Zfpm2 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process atrioventricular valve morphogenesis, cardiac muscle tissue development, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (187)    Tissues (72)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 10
RT-PCR 74
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(28) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022306 (Evidence)
Entrez Gene22762 (Evidence)
UniGene39496
DFCITC1615304, TC1596889, TC1581986
DoTSDT.91555346, DT.87031450, DT.102537755, DT.40169898
NIA Mouse Gene IndexU097362
Consensus CDS ProjectCCDS27447.1
International Mouse Knockout Project StatusZfpm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22762 NCBI Gene Model | MGI Sequence Detail 449551 C57BL/6J ±  kb
transcript NM_011766 RefSeq | MGI Sequence Detail 4974 C57BL/6 
polypeptide Q8CCH7 UniProt | EBI | MGI Sequence Detail 1151 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(3989 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017653 zinc finger protein ZFPM2
Graphical View of Protein Domain Structure
References
(Earliest) J:52532 Tevosian SG, et al., FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5
(Latest) J:210221 Mandai K, et al., Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014 Jun 11;
All references(92)
Disease annotation references (4)
Other
accession IDs
MGI:2444606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory