Bub1b
Gene Detail

Symbol Name ID

Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) MGI:1333889

Synonyms

BUBR1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

59.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:118598211-118641591 bp, + strand From VEGA annotation of GRCm38   43381 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bub1b

Human homologs

Human Homolog		BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B
NCBI Gene ID		701
neXtProt AC		NX_O60566
Human Synonyms		Bub1A, BUB1beta, BUBR1, hBUBR1, MAD3L, MVA1, SSK1
Human Chr (Location)		15q15; chr15:40453210-40513337 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human BUB1B

Alleles and phenotypes

All alleles(29) : Targeted(4) Gene trapped(25)
 

Homozygous mutant embryos undergo extensive apoptosis and die during early gestation. Heterozygous mice are viable and exhibit splenomegaly, abnormal megakaryopoiesis, and an increased susceptibility to intestinal tumorigenesis. Hypomorphic homozygotes display infertility and premature aging.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	apoptotic process, cell cycle, ...
Component	chromosome, chromosome, centromeric region, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (470)    Tissues (158)    Images (47)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	459
Northern blot	9
RT-PCR	2

cDNA source data(138)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(140) cDNA(138) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015367 (Evidence)
Ensembl Gene Model	ENSMUSG00000040084 (Evidence)
Entrez Gene	12236 (Evidence)
UniGene	29133
DFCI	TC1575535
DoTS	DT.531579, DT.94211521
NIA Mouse Gene Index	U002280
EC	2.7.11.1
Consensus CDS Project	CCDS16579.1
International Mouse Knockout Project Status	Bub1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015367	VEGA Gene Model | MGI Sequence Detail	43381	C57BL/6J
transcript	OTTMUST00000036418	VEGA | MGI Sequence Detail	3668	Not Applicable
polypeptide	OTTMUSP00000016369	VEGA | MGI Sequence Detail	1052	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(202 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013212	Mad3/BUB1 homology region 1
InterPro	IPR015661	Mitotic checkpoint serine/threonine protein kinase, Bub1
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000004855	mitotic checkpoint serine/threonine-protein kinase BUB1 beta

References

(Earliest) J:52194 Davenport JW, et al., The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. Genomics. 1999 Jan 1;55(1):113-7
(Latest) J:195234 Baker DJ, et al., Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013 Jan;15(1):96-102
All references(67)

Other accession IDs

MGI:2139222