About   Help   FAQ
Bub1b
Gene Detail
Symbol

Name
ID
Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
MGI:1333889
Synonyms
BUBR1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:118598211-118641591 bp, + strand
From VEGA annotation of GRCm38

  43381 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BUB1B
Gene Tree: Bub1b

Human
homologs
BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 701
neXtProt AC: NX_O60566

Human Synonyms: Bub1A, BUB1beta, BUBR1, hBUBR1, MAD3L, MVA1, SSK1

Human Chr (Location): 15q15; chr15:40161009-40221136 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BUB1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(25) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos undergo extensive apoptosis and die during early gestation. Heterozygous mice are viable and exhibit splenomegaly, abnormal megakaryopoiesis, and an increased susceptibility to intestinal tumorigenesis. Hypomorphic homozygotes display infertility and premature aging.
 
Human Diseases Modeled in Mice Using Bub1b (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Bub1b interacts with 89 markers (Mir7-1, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process apoptotic process, cell cycle, ...
Component chromosome, chromosome, centromeric region, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (470)    Tissues (158)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 459
Northern blot 9
RT-PCR 2
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BUB1B ; Xenbase bub1b ; ZFIN bub1bb    NEW 
Molecular
reagents
All nucleic(142) cDNA(140) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015367 (Evidence)
Ensembl Gene Model ENSMUSG00000040084 (Evidence)
Entrez Gene 12236 (Evidence)
UniGene 29133
DFCI TC1575535
DoTS DT.531579, DT.94211521
NIA Mouse Gene Index U002280
EC 2.7.11.1
Consensus CDS Project CCDS16579.1
International Mouse Phenotyping Consortium Status Bub1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015367 VEGA Gene Model | MGI Sequence Detail 43381 C57BL/6J ±  kb
transcript OTTMUST00000036418 VEGA | MGI Sequence Detail 3668 Not Applicable 
polypeptide OTTMUSP00000016369 VEGA | MGI Sequence Detail 1052 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(431 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013212 Mad3/BUB1 homology region 1
InterPro IPR015661 Mitotic checkpoint serine/threonine protein kinase Bub1/Mitotic spindle checkpoint component Mad3
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
References
(Earliest) J:52194 Davenport JW, et al., The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. Genomics. 1999 Jan 1;55(1):113-7
(Latest) J:216369 Knouse KA, et al., Single cell sequencing reveals low levels of aneuploidy across mammalian tissues. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13409-14
All references(76)
Disease annotation references (1)
Other
accession IDs
MGI:2139222

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory