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Xrcc4
Gene Detail
 Symbol
Name
ID
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
MGI:1333799
Synonyms 2310057B22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:89774027-90089608 bp, - strand
From VEGA annotation of GRCm38

  315582 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2555  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xrcc4

Human
homologs
Human Homolog XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4
NCBI Gene ID 7518
neXtProt AC  NX_Q13426
Human Chr (Location)  5q14.2; chr5:83077498-83353760 (+)  GRCh38
Alleles
and
phenotypes
All alleles(35) : Gene trapped(31) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have massive neuronal apoptosis, growth retardation, hypoplastic thymus and die by embryonic day 17.5. Lethality is rescued by Trp53 deficiency, but double knockout mice die from pro-B-cell lymphomas with Myc-Igh translocations.
 
Human Diseases Modeled Using Mouse Xrcc4 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to DNA damage stimulus, central nervous system development, ...
Component cell junction, centrosome, ...
Function DNA binding, protein C-terminus binding
External Resources: FuncBase
Expression
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035049 (Evidence)
Ensembl Gene ModelENSMUSG00000021615 (Evidence)
Entrez Gene108138 (Evidence)
UniGene37531
DFCITC1581910, TC1618378, TC1712429
DoTSDT.101324722, DT.101708248, DT.40171862, DT.60100047
NIA Mouse Gene IndexU035009, U378131
Consensus CDS ProjectCCDS26673.1
International Mouse Knockout Project StatusXrcc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035049 VEGA Gene Model | MGI Sequence Detail 315582 C57BL/6J ±  kb
transcript OTTMUST00000089147 VEGA | MGI Sequence Detail 1540 Not Applicable 
polypeptide OTTMUSP00000048674 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(3)
Polymorphisms SNPs within 2kb(2076 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2082)
Protein-related
information
ResourceIDDescription
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
InterPro IPR010585 DNA repair protein XRCC4
InterPro IPR014751 DNA repair protein XRCC4, C-terminal
Protein Ontology PR:000017507 DNA repair protein XRCC4
References (Earliest) J:19354 Yamano M, et al., Distribution of corticotropin-releasing factor and calcitonin gene-related peptide in the developing mouse cerebellum. Neurosci Res. 1994 Jun;19(4):387-96
(Latest) J:194333 Oksenych V, et al., Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2234-9
All references(67)
Other
accession IDs
MGI:1919195, MGI:2145428, MGI:2145445

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory