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Xrcc4
Gene Detail
Symbol

Name
ID
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
MGI:1333799
Synonyms
2310057B22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:89774027-90089608 bp, - strand
From VEGA annotation of GRCm38

  315582 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2555  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: XRCC4
Gene Tree: Xrcc4

Human
homologs
XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7518
neXtProt AC: NX_Q13426

Human Chr (Location): 5q14.2; chr5:83077409-83353760 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(31) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have massive neuronal apoptosis, growth retardation, hypoplastic thymus and die by embryonic day 17.5. Lethality is rescued by Trp53 deficiency, but double knockout mice die from pro-B-cell lymphomas with Myc-Igh translocations.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Xrcc4 interacts with 289 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cellular response to DNA damage stimulus, central nervous system development, ...
Component cell junction, centrosome, ...
Function DNA binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xrcc4 ; ZFIN xrcc4    NEW 
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035049 (Evidence)
Ensembl Gene Model ENSMUSG00000021615 (Evidence)
Entrez Gene 108138 (Evidence)
UniGene 37531
DFCI TC1581910, TC1618378, TC1712429
DoTS DT.101324722, DT.60100047, DT.40171862, DT.101708248
NIA Mouse Gene Index U378131, U035009
Consensus CDS Project CCDS26673.1
International Mouse Phenotyping Consortium Status Xrcc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035049 VEGA Gene Model | MGI Sequence Detail 315582 C57BL/6J ±  kb
transcript OTTMUST00000089147 VEGA | MGI Sequence Detail 1540 Not Applicable 
polypeptide OTTMUSP00000048674 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(2076 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2082)
Protein-related
information
ResourceIDDescription
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
InterPro IPR010585 DNA repair protein XRCC4
InterPro IPR014751 DNA repair protein XRCC4, C-terminal
Protein Ontology PR:000017507 DNA repair protein XRCC4
References
(Earliest) J:19354 Yamano M, et al., Distribution of corticotropin-releasing factor and calcitonin gene-related peptide in the developing mouse cerebellum. Neurosci Res. 1994 Jun;19(4):387-96
(Latest) J:220823 Jiang W, et al., Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Mol Cell. 2015 Apr 2;58(1):172-85
All references(67)
Other
accession IDs
MGI:1919195, MGI:2145428, MGI:2145445

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory