Xrcc4
Gene Detail

Symbol Name ID

Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 MGI:1333799

Synonyms

2310057B22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

45.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:89774027-90089608 bp, - strand From VEGA annotation of GRCm38   315582 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2555  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xrcc4

Human homologs

Human Homolog		XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4
NCBI Gene ID		7518
neXtProt AC		NX_Q13426
Human Chr (Location)		5q14.2; chr5:82373317-82649579 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(35) : Targeted(4) Gene trapped(31)
 

Homozygous null mutants have massive neuronal apoptosis, growth retardation, hypoplastic thymus and die by embryonic day 17.5. Lethality is rescued by Trp53 deficiency, but double knockout mice die from pro-B-cell lymphomas with Myc-Igh translocations.

 
Human Diseases Modeled Using Mouse Xrcc4 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	central nervous system development, DNA ligation, ...
Component	cytosol, DNA-dependent protein kinase-DNA ligase 4 complex, ...
Function	DNA binding, protein C-terminus binding

External Resources: FuncBase

Expression

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(23)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035049 (Evidence)
Ensembl Gene Model	ENSMUSG00000021615 (Evidence)
Entrez Gene	108138 (Evidence)
UniGene	37531
DFCI	TC1581910, TC1618378, TC1712429
DoTS	DT.101324722, DT.101708248, DT.40171862, DT.60100047
NIA Mouse Gene Index	U035009, U378131
Consensus CDS Project	CCDS26673.1
International Mouse Knockout Project Status	Xrcc4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035049	VEGA Gene Model | MGI Sequence Detail	315582	C57BL/6J
transcript	OTTMUST00000089147	VEGA | MGI Sequence Detail	1540	Not Applicable
polypeptide	OTTMUSP00000048674	VEGA | MGI Sequence Detail	326	Not Applicable

All sequences(45) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(1149 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010585	DNA double-strand break repair and VJ recombination XRCC4
InterPro	IPR014751	DNA double-strand break repair and VJ recombination XRCC4, C-terminal
InterPro	IPR009089	DNA double-strand break repair and VJ recombination XRCC4, N-terminal
Protein Ontology	PR:000017507	DNA repair protein XRCC4

References

(Earliest) J:19354 Yamano M, et al., Distribution of corticotropin-releasing factor and calcitonin gene-related peptide in the developing mouse cerebellum. Neurosci Res. 1994 Jun;19(4):387-96
(Latest) J:194333 Oksenych V, et al., Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2234-9
All references(67)

Other accession IDs

MGI:1919195, MGI:2145428, MGI:2145445