Xrcc4 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrcc4
X-ray repair complementing 4
MGI:1333799

11 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal class switch recombination	J:150339
	spontaneous chromosome breakage	J:150339
Xrcc4^tm1Fwa/Xrcc4^tm1Fwa involves: 129P2/OlaHsd	abnormal cell physiology	J:110848
	abnormal DNA repair	J:120145
	increased cellular sensitivity to gamma-irradiation	J:120145
	increased neuron apoptosis	J:110848
	spontaneous chromosome breakage	J:120145
	thin cerebral cortex	J:110848
Xrcc4^tm1Fwa/Xrcc4^tm1Fwa involves: 129P2/OlaHsd * C57BL/6	abnormal cerebral cortex morphology	J:65218
	fetal growth retardation	J:65218
	lethality throughout fetal growth and development, complete penetrance	J:65218
	thymus hypoplasia	J:65218

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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