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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
MGI:1333799
19 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aicdatm1Hon/Aicdatm1Hon
Tg(Cr2-cre)3Cgn/?
Xrcc4tm1Fwa/Xrcc4tm2Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA 		spontaneous chromosome breakage J:150339
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
Lig4tm1Fwa/Lig4tm1Fwa
Tg(Cr2-cre)3Cgn/0
Xrcc4tm2Fwa/Xrcc4tm2Fwa
involves: 129S6/SvEvTac 		abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
Rag2tm1Cgn/Rag2tm1Cgn
Xrcc4tm1Fwa/Xrcc4tm2Fwa
Tg(Cr2-cre)3Cgn/?
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal class switch recombination J:150339
spontaneous chromosome breakage J:150339
Trp53tm1Brd/Trp53+
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL 		normal mortality/aging J:109585
Trp53tm1Brd/Trp53tm1Brd
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal cerebellar granule layer morphology J:109585
abnormal cerebellum vermis morphology J:109585
enlarged cranium J:109585
increased medulloblastoma incidence J:109585
premature death J:109585
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal lymphopoiesis J:61973
increased B cell derived lymphoma incidence J:61973
postnatal growth retardation J:61973
premature death J:61973
Trp53tm1Xu/Trp53tm1Xu
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal apoptosis J:109354
normal mortality/aging J:109354
Trp53tm2Xu/Trp53tm2Xu
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal tumor incidence J:109354
decreased body size J:109354
kyphoscoliosis J:109354
normal mortality/aging J:109354
testicular atrophy J:109354
thin skin J:109354
Trp53tm3.1Holl/Trp53tm3.1Holl
Xrcc4tm1Fwa/Xrcc4tm1Fwa
involves: 129P2/OlaHsd 		embryonic lethality, complete penetrance J:191183
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory