Trp53^tm3.1Holl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3.1Holl
• Name: transformation related protein 53; targeted mutation 3.1, Monica Hollstein
• MGI ID: MGI:5465276
• Synonyms: p53hki^S46A
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3.1Holl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191183
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 9 were replaced with corresponding exons from the human gene with a sequence variant that results in the amino acid substitution of serine with alanine at position 46 (p.S46A). Cre-mediated recombination removed the Loxp site flanked neomycin resistance gene cassette inserted into intron 3. (J:191183)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:191183 Feng L, et al., Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle. 2006 Dec;5(23):2812-9
• All: 1 reference(s)