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Matn3
Gene Detail
Symbol

Name
ID
Matn3
matrilin 3
MGI:1328350
Feature Type
protein coding gene
Genetic Map
Chromosome 12
3.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:8947929-8972028 bp, + strand
From VEGA annotation of GRCm38

  24100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MATN3
Protein SuperFamily: cartilage matrix protein
Gene Tree: Matn3

Human
homologs
MATN3, matrilin 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4148
neXtProt AC: NX_O15232

Human Synonyms: DIPOA, EDM5, HOA, OADIP, OS2

Human Chr (Location): 2p24-p23; chr2:19992052-20012694 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human MATN3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Human Diseases Modeled in Mice Using Matn3 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Matn3 interacts with 204 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process chondrocyte differentiation, skeletal system development
Component extracellular region, proteinaceous extracellular matrix
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (183)    Tissues (41)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 169
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MATN3 ZFIN matn3a, matn3b    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030695 (Evidence)
Ensembl Gene Model ENSMUSG00000020583 (Evidence)
Entrez Gene 17182 (Evidence)
UniGene 42226
DFCI TC1585533, TC1727729
DoTS DT.94172581, DT.91330166, DT.94174547, DT.94174543
NIA Mouse Gene Index U013747
Consensus CDS Project CCDS25806.1
International Mouse Phenotyping Consortium Status Matn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030695 VEGA Gene Model | MGI Sequence Detail 24100 C57BL/6J ±  kb
transcript OTTMUST00000075996 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000039934 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR019466 Matrilin, coiled-coil trimerisation domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000010207 matrilin-3
References
(Earliest) J:51112 Wagener R, et al., Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 1997 Aug 11;413(1):129-34
(Latest) J:218286 Yang X, et al., Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. J Biol Chem. 2014 Dec 12;289(50):34768-79
All references(47)
Disease annotation references (2)
Other
accession IDs
MGI:2144975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory