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Matn3
Gene Detail
 Symbol
Name
ID
Matn3
matrilin 3
MGI:1328350
Feature Type protein coding gene
Genetic Map
Chromosome 12
3.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:8947929-8972028 bp, + strand
From VEGA annotation of GRCm38

  24100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: cartilage matrix protein
Gene Tree: Matn3

Human
homologs
Human Homolog MATN3, matrilin 3
NCBI Gene ID 4148
neXtProt AC  NX_O15232
Human Synonyms  DIPOA, EDM5, HOA, OADIP, OS2
Human Chr (Location)  2p24-p23; chr2:19992052-20012694 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human MATN3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Human Diseases Modeled Using Mouse Matn3 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Matn3 interacts with 204 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component extracellular region, proteinaceous extracellular matrix
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (183)    Tissues (41)    Images (23)
Theiler Stages: 16, 18, 21, 22, 23, 24, 26
Assay TypeResults
Immunohistochemistry 14
RNA in situ 169
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030695 (Evidence)
Ensembl Gene ModelENSMUSG00000020583 (Evidence)
Entrez Gene17182 (Evidence)
UniGene42226
DFCITC1585533, TC1727729
DoTSDT.91330166, DT.94172581, DT.94174543, DT.94174547
NIA Mouse Gene IndexU013747
Consensus CDS ProjectCCDS25806.1
International Mouse Knockout Project StatusMatn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030695 VEGA Gene Model | MGI Sequence Detail 24100 C57BL/6J ±  kb
transcript OTTMUST00000075996 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000039934 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR019466 Matrilin, coiled-coil trimerisation domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000010207 matrilin-3
References (Earliest) J:51112 Wagener R, et al., Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 1997 Aug 11;413(1):129-34
(Latest) J:209751 Pirog KA, et al., Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases. PLoS One. 2013;8(11):e82412
All references(47)
Disease annotation references (2)
Other
accession IDs
MGI:2144975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory