Matn3
Gene Detail

Symbol Name ID

Matn3 matrilin 3 MGI:1328350

Feature Type

protein coding gene

Genetic Map

Chromosome 12

3.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:8947929-8972028 bp, + strand From VEGA annotation of GRCm38   24100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cartilage matrix protein
Gene Tree: Matn3

Human homologs

Human Homolog		MATN3, matrilin 3
NCBI Gene ID		4148
neXtProt AC		NX_O15232
Human Synonyms		DIPOA, EDM5, HOA, OADIP, OS2
Human Chr (Location)		2p24-p23; chr2:20191813-20212455 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MATN3

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 
Human Diseases Modeled Using Mouse Matn3 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Component	extracellular region, proteinaceous extracellular matrix
Function	calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (183)    Tissues (41)    Images (23)
Theiler Stages: 16, 18, 21, 22, 23, 24, 26

Assay Type	Results
Immunohistochemistry	14
RNA in situ	169

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030695 (Evidence)
Ensembl Gene Model	ENSMUSG00000020583 (Evidence)
Entrez Gene	17182 (Evidence)
UniGene	42226
DFCI	TC1585533, TC1727729
DoTS	DT.91330166, DT.94172581, DT.94174543, DT.94174547
NIA Mouse Gene Index	U013747
Consensus CDS Project	CCDS25806.1
International Mouse Knockout Project Status	Matn3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030695	VEGA Gene Model | MGI Sequence Detail	24100	C57BL/6J
transcript	OTTMUST00000075996	VEGA | MGI Sequence Detail	3014	Not Applicable
polypeptide	OTTMUSP00000039934	VEGA | MGI Sequence Detail	481	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR019466	Matrilin, coiled-coil trimerisation domain
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000010207	matrilin-3

References

(Earliest) J:51112 Wagener R, et al., Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 1997 Aug 11;413(1):129-34
(Latest) J:181901 Eitzinger N, et al., Ucma is not necessary for normal development of the mouse skeleton. Bone. 2012 Mar;50(3):670-80
All references(44)

Other accession IDs

MGI:2144975