Fzd9
Gene Detail

Symbol Name ID

Fzd9 frizzled homolog 9 (Drosophila) MGI:1313278

Synonyms

frizzled 9, mfz9

Feature Type

protein coding gene

Genetic Map

Chromosome 5

75.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr5:135248938-135251230 bp, - strand From VEGA annotation of GRCm38   2293 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd9 ± 2 cM)

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd9

Human ortholog

FZD9 frizzled family receptor 9 NCBI Gene ID 8326
Human Synonyms: CD349, FZD3
Human Chr7:72848109-72850450 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for one allele exhibit immune system abnormalities while another null allele causes neurological abnormalities. A third null mutation results in growth retardation and abnormalities in bone mineralization.

 
Human Diseases Modeled Using Mouse Fzd9 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	B cell differentiation, brain development, ...
Component	cell surface, cytoplasm, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (449)    Tissues (160)    Images (51)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 14, 15, 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	372
Northern blot	20
RT-PCR	57

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(4) cDNA(16) Primer pair(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021311 (Evidence)
Ensembl Gene Model	ENSMUSG00000049551 (Evidence)
Entrez Gene	14371 (Evidence)
UniGene	6256
DFCI	TC1587026
DoTS	DT.40169831
NIA Mouse Gene Index	U026816
Consensus CDS Project	CCDS51661.1
International Mouse Knockout Project Status	Fzd9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021311	VEGA Gene Model | MGI Sequence Detail	2293	C57BL/6J
transcript	OTTMUST00000050527	VEGA | MGI Sequence Detail	2293	Not Applicable
polypeptide	OTTMUSP00000023598	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026546	Frizzled-9
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000001455	frizzled-9

References

(Earliest) J:49924 Wang YK, et al., Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics. 1999 Apr 15;57(2):235-48
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(72)