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Fzd9
Gene Detail
Symbol

Name
ID
Fzd9
frizzled homolog 9 (Drosophila)
MGI:1313278
Synonyms
frizzled 9, mfz9
Feature Type
protein coding gene
Genetic Map
Chromosome 5
75.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:135248938-135251230 bp, - strand
From VEGA annotation of GRCm38

  2293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FZD9
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd9

Human
homologs
FZD9, frizzled class receptor 9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8326
neXtProt AC: NX_O00144

Human Synonyms: CD349, FZD3

Human Chr (Location): 7q11.23; chr7:73433779-73436120 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Fzd9 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one allele exhibit immune system abnormalities while another null allele causes neurological abnormalities. A third null mutation results in growth retardation and abnormalities in bone mineralization.
 
Human Diseases Modeled in Mice Using Fzd9 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Fzd9 interacts with 62 markers (Mir18, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process B cell differentiation, canonical Wnt signaling pathway, ...
Component cell surface, cytoplasm, ...
Function G-protein coupled receptor activity, protein heterodimerization activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (499)    Tissues (210)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 421
Northern blot 20
RT-PCR 58
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fzd9 ; ZFIN fzd9a, fzd9b    NEW 
Molecular
reagents
All nucleic(30) Genomic(4) cDNA(16) Primer pair(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021311 (Evidence)
Ensembl Gene Model ENSMUSG00000049551 (Evidence)
Entrez Gene 14371 (Evidence)
UniGene 6256
DFCI TC1587026
DoTS DT.40169831
NIA Mouse Gene Index U026816
Consensus CDS Project CCDS51661.1
International Mouse Phenotyping Consortium Status Fzd9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021311 VEGA Gene Model | MGI Sequence Detail 2293 C57BL/6J ±  kb
transcript OTTMUST00000050527 VEGA | MGI Sequence Detail 2293 Not Applicable 
polypeptide OTTMUSP00000023598 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000001455 frizzled-9
References
(Earliest) J:49924 Wang YK, et al., Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics. 1999 Apr 15;57(2):235-48
(Latest) J:211112 Heilmann A, et al., The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PLoS One. 2013;8(12):e84232
All references(74)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory