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Fzd9 Gene Detail
Summary
  • Symbol
    Fzd9
  • Name
    frizzled class receptor 9
  • Synonyms
    frizzled 9, mfz9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313278
    NCBI Gene: 14371
  • Gene Overview
    MyGene.info: FZD9
Location & Maps
more
  • Sequence Map
    Chr5:135248938-135251230 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2293 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.08 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    FZD9, frizzled class receptor 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD9, frizzled class receptor 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD349, FZD3
  • Links
    NCBI Gene ID: 8326
    neXtProt AC: NX_O00144

  • Chr Location
    7q11.23; chr7:73433779-73436120 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Fzd9 mouse models

Human Disease Mouse Models
       Williams-Beuren Syndrome; WBS   OMIM: 194050 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Genomic Mutations
    2 involving Fzd9
  • Incidental Mutations
Mice homozygous for one allele exhibit immune system abnormalities while another null allele causes neurological abnormalities. A third null mutation results in growth retardation and abnormalities in bone mineralization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021311 VEGA Gene Model | MGI Sequence Detail 2293 C57BL/6J ±  kb
transcript OTTMUST00000050527 VEGA | MGI Sequence Detail 2293 Not Applicable  
polypeptide OTTMUSP00000023598 VEGA | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    23 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 30
    Genomic 4
    cDNA 16
    Primer pair 10

    Microarray probesets 3
References
more
  • Summaries
    All 72
    Developmental Gene Expression 33
    Diseases 6
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:49924 Wang YK, et al., Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics. 1999 Apr 15;57(2):235-48
  • Latest
    J:211112 Heilmann A, et al., The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PLoS One. 2013;8(12):e84232

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory