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Fzd9tm1Sjp
Targeted Allele Detail
Summary
Symbol: Fzd9tm1Sjp
Name: frizzled class receptor 9; targeted mutation 1, Samuel J Pleasure
MGI ID: MGI:3586504
Gene: Fzd9  Location: Chr5:135277792-135279901 bp, - strand  Genetic Position: Chr5, 75.08 cM
Alliance: Fzd9tm1Sjp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99893
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire 1.8 kb coding exon was replaced by an IRES-lacZ-loxP-neo-loxP cassette. RT-PCR of mutant brain confirmed recomibination and expression of lacZ. X-gal staining, however, did not detect lacZ. Immunohistochemistry demonstrated lack of endogenous protein in mutants. (J:99893)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd9 Mutation:  28 strains or lines available
References
Original:  J:99893 Zhao C, et al., Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development. 2005 Jun;132(12):2917-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/28/2023
MGI 6.22
The Jackson Laboratory