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Vamp2 Gene Detail
Summary
  • Symbol
    Vamp2
  • Name
    vesicle-associated membrane protein 2
  • Synonyms
    Syb2, Syb-2, sybII, synaptobrevin-2, synaptobrevin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313277
    NCBI Gene: 22318
  • Gene Overview
    MyGene.info: VAMP2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69088528-69092381 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.36 cM
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313277
protein coding gene Chr11:69088490-69092384 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018517
protein coding gene Chr11:69493874-69497753 (+)
A/J MGP_AJ_G0018486
protein coding gene Chr11:66879577-66883471 (+)
AKR/J MGP_AKRJ_G0018455
protein coding gene Chr11:68883452-68887346 (+)
BALB/cJ MGP_BALBcJ_G0018457
protein coding gene Chr11:67201525-67205419 (+)
C3H/HeJ MGP_C3HHeJ_G0018270
protein coding gene Chr11:68900116-68904010 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018909
protein coding gene Chr11:71604743-71608637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016553
protein coding gene Chr11:63819907-63823803 (+)
CAST/EiJ MGP_CASTEiJ_G0017826
protein coding gene Chr11:69137367-69141272 (+)
CBA/J MGP_CBAJ_G0018244
protein coding gene Chr11:74815589-74819483 (+)
DBA/2J MGP_DBA2J_G0018353
protein coding gene Chr11:66478817-66482709 (+)
FVB/NJ MGP_FVBNJ_G0018343
protein coding gene Chr11:66100291-66104185 (+)
LP/J MGP_LPJ_G0018424
protein coding gene Chr11:70080984-70084863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018366
protein coding gene Chr11:75441929-75445823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018950
protein coding gene Chr11:69128712-69132606 (+)
PWK/PhJ MGP_PWKPhJ_G0017601
protein coding gene Chr11:67115506-67119397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017389
protein coding gene Chr11:68961683-68965591 (+)
WSB/EiJ MGP_WSBEiJ_G0017879
protein coding gene Chr11:68768760-68772661 (+)



Homology
more
  • Human Ortholog
    VAMP2, vesicle associated membrane protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VAMP2, vesicle associated membrane protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SYB2, VAMP-2
  • Links
    NCBI Gene ID: 6844
    neXtProt AC: NX_P63027
    UniProt: P63027

  • Chr Location
    17p13.1; chr17:8159147-8162975 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22318 NCBI Gene Model | MGI Sequence Detail 3854 C57BL/6J ±  kb
    transcript NM_009497 RefSeq | MGI Sequence Detail 2164 C57BL/6  
    polypeptide P63044 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001388 Synaptobrevin
      IPR016444 Synaptobrevin/Vesicle-associated membrane protein
      IPR028717 Vesicle-associated membrane protein 2
    Molecular
    Reagents
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    • All nucleic 136
      cDNA 134
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14676, MGD-MRK-14678, MGI:98459
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 32
      Gene Ontology 45
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264328 Chiang CW, et al., The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux through Synaptic Fusion Pores. J Neurosci. 2018 Aug 8;38(32):7179-7191

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory