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Vamp2 Gene Detail
Summary
  • Symbol
    Vamp2
  • Name
    vesicle-associated membrane protein 2
  • Synonyms
    Syb2, Syb-2, sybII, synaptobrevin-2, synaptobrevin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313277
    NCBI Gene: 22318
Location & Maps
more
  • Sequence Map
    Chr11:69088490-69092384 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3895 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VAMP2, vesicle associated membrane protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VAMP2, vesicle associated membrane protein 2
    Orthology source: HomoloGene
  • Synonyms
    SYB2, VAMP-2
  • Links
    NCBI Gene ID: 6844
    neXtProt AC: NX_P63027

  • Chr Location
    17p13.1; chr17:8159147-8162975 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Vamp2
  • Incidental Mutations
Homozygous null mutants show 10X reduction in synaptic vesicle fusion and hypertonic sucrose-induced fusion and >100X reduction in fusion triggered by fast Ca2+. Newborn pups are rounded in appearance, with humped shoulders, and die immediately.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005972 VEGA Gene Model | MGI Sequence Detail 3895 C57BL/6J ±  kb
transcript OTTMUST00000013341 VEGA | MGI Sequence Detail 1113 Not Applicable  
polypeptide OTTMUSP00000035737 VEGA | MGI Sequence Detail 163 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 137
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001388 Synaptobrevin
    IPR016444 Synaptobrevin/Vesicle-associated membrane protein
Molecular
Reagents
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  • All nucleic 134
    cDNA 133
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14676, MGD-MRK-14678, MGI:98459
References
more
  • Summaries
    All 112
    Developmental Gene Expression 25
    Gene Ontology 35
    Phenotypes 25
  • Earliest
    J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
  • Latest
    J:226428 Ouseph MM, et al., Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood. 2015 Sep 3;126(10):1224-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory