Mapk8ip1
Gene Detail

Symbol Name ID

Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 MGI:1309464

Synonyms

IB1, Jip1, JIP-1, MAPK8IP1, mjip-2a, Prkm8ip, Skip

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.99 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:92383676-92401263 bp, - strand From VEGA annotation of GRCm38   17588 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mapk8ip1

Human homologs

Human Homolog		MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
NCBI Gene ID		9479
neXtProt AC		NX_Q9UQF2
Human Synonyms		IB1, JIP1, JIP-1, PRKM8IP
Human Chr (Location)		11p11.2; chr11:45907047-45928016 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAPK8IP1

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous mutation of this gene results in a decreased susceptibility to ischemic brain injury.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	JUN phosphorylation, negative regulation of apoptotic process, ...
Component	axon, axonal growth cone, ...
Function	JUN kinase binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (134)    Tissues (39)    Images (27)
Theiler Stages: 17, 19, 23, 26, 28

Assay Type	Results
RNA in situ	120
Northern blot	11
Western blot	3

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(42) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014470 (Evidence)
Ensembl Gene Model	ENSMUSG00000027223 (Evidence)
Entrez Gene	19099 (Evidence)
UniGene	2720
DFCI	TC1574456, TC1615193, TC1646646
DoTS	DT.101395094, DT.101395103, DT.97338211, DT.97356778, DT.97380804
NIA Mouse Gene Index	U023035
PDB	1UKH, 1UKI, 3O2M, 3O17
Consensus CDS Project	CCDS16446.1, CCDS57180.1
International Mouse Knockout Project Status	Mapk8ip1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014470	VEGA Gene Model | MGI Sequence Detail	17588	C57BL/6J
transcript	OTTMUST00000034344	VEGA | MGI Sequence Detail	2930	Not Applicable
polypeptide	OTTMUSP00000015385	VEGA | MGI Sequence Detail	707	Not Applicable

All sequences(52) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000010160	C-Jun-amino-terminal kinase-interacting protein 1

References

(Earliest) J:50502 Dickens M, et al., A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 1997 Aug 1;277(5326):693-6
(Latest) J:182978 Vagnoni A, et al., Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J Cell Sci. 2011 Apr 1;124(Pt 7):1032-42
All references(68)