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Mapk8ip1
Gene Detail
 Symbol
Name
ID
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
MGI:1309464
Synonyms IB1, Jip1, JIP-1, MAPK8IP1, mjip-2a, Prkm8ip, Skip
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.99 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:92383676-92401263 bp, - strand
From VEGA annotation of GRCm38

  17588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mapk8ip1

Human
homologs
Human Homolog MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
NCBI Gene ID 9479
neXtProt AC  NX_Q9UQF2
Human Synonyms  IB1, JIP1, JIP-1, PRKM8IP
Human Chr (Location)  11p11.2; chr11:45885496-45906465 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAPK8IP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Mapk8ip1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in a decreased susceptibility to ischemic brain injury.
 
Interactions
Mapk8ip1 interacts with 106 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process JUN phosphorylation, negative regulation of apoptotic process, ...
Component axon, axonal growth cone, ...
Function identical protein binding, JUN kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (134)    Tissues (39)    Images (27)
Theiler Stages: 17, 19, 23, 26, 28
Assay TypeResults
RNA in situ 120
Northern blot 11
Western blot 3
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(41) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014470 (Evidence)
Ensembl Gene ModelENSMUSG00000027223 (Evidence)
Entrez Gene19099 (Evidence)
UniGene2720
DFCITC1574456, TC1615193, TC1646646
DoTSDT.101395094, DT.101395103, DT.97338211, DT.97356778, DT.97380804
NIA Mouse Gene IndexU023035
PDB1UKH, 1UKI, 3O2M, 3V3V, 3O17
Consensus CDS ProjectCCDS16446.1, CCDS57180.1
International Mouse Knockout Project StatusMapk8ip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014470 VEGA Gene Model | MGI Sequence Detail 17588 C57BL/6J ±  kb
transcript OTTMUST00000034344 VEGA | MGI Sequence Detail 2930 Not Applicable 
polypeptide OTTMUSP00000015385 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000010160 C-Jun-amino-terminal kinase-interacting protein 1
References (Earliest) J:50502 Dickens M, et al., A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 1997 Aug 1;277(5326):693-6
(Latest) J:201637 Fu MM, et al., JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol. 2013 Aug 5;202(3):495-508
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory