About   Help   FAQ
Mapk8ip1 Gene Detail
Summary
  • Symbol
    Mapk8ip1
  • Name
    mitogen-activated protein kinase 8 interacting protein 1
  • Synonyms
    IB1, Jip1, JIP-1, MAPK8IP1, mjip-2a, Prkm8ip, Skip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309464
    NCBI Gene: 19099
  • Gene Overview
    MyGene.info: MAPK8IP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:92383676-92401263 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17588 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.99 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IB1, JIP1, JIP-1, PRKM8IP
  • Links
    NCBI Gene ID: 9479
    neXtProt AC: NX_Q9UQF2
    UniProt: Q9UQF2

  • Chr Location
    11p11.2; chr11:45885496-45906465 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MAPK8IP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014470 VEGA Gene Model | MGI Sequence Detail 17588 C57BL/6J ±  kb
    transcript OTTMUST00000034344 VEGA | MGI Sequence Detail 2930 Not Applicable  
    polypeptide OTTMUSP00000015385 VEGA | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 13
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261206 Morel C, et al., JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018 Apr 11;38(15):3708-3728

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory