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Sart1 Gene Detail
Summary
  • Symbol
    Sart1
  • Name
    squamous cell carcinoma antigen recognized by T cells 1
  • Synonyms
    U5-110K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309453
    NCBI Gene: 20227
  • Gene Overview
    MyGene.info: SART1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5377523-5388703 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.31 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309453
protein coding gene Chr19:5377523-5389304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024702
protein coding gene Chr19:2334993-2348007 (-)
A/J MGP_AJ_G0024668
protein coding gene Chr19:2210766-2221716 (-)
AKR/J MGP_AKRJ_G0024641
protein coding gene Chr19:2272640-2283590 (-)
BALB/cJ MGP_BALBcJ_G0024668
protein coding gene Chr19:2206861-2217811 (-)
C3H/HeJ MGP_C3HHeJ_G0024436
protein coding gene Chr19:2278393-2289343 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025115
protein coding gene Chr19:2394865-2407915 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022545
protein coding gene Chr19:2117038-2128064 (-)
CAST/EiJ MGP_CASTEiJ_G0023908
protein coding gene Chr19:2307515-2319720 (-)
CBA/J MGP_CBAJ_G0024408
protein coding gene Chr19:2500396-2511702 (-)
DBA/2J MGP_DBA2J_G0024535
protein coding gene Chr19:2190660-2201968 (-)
FVB/NJ MGP_FVBNJ_G0024502
protein coding gene Chr19:2198131-2209089 (-)
LP/J MGP_LPJ_G0024621
protein coding gene Chr19:2318120-2330819 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024532
protein coding gene Chr19:2352241-2363191 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025163
protein coding gene Chr19:2273695-2286308 (-)
PWK/PhJ MGP_PWKPhJ_G0023654
protein coding gene Chr19:2228439-2239434 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023459
protein coding gene Chr19:2264160-2275099 (-)
WSB/EiJ MGP_WSBEiJ_G0023970
protein coding gene Chr19:2291074-2302032 (-)



Homology
more
  • Human Ortholog
    SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Ara1, HAF, HOMS1, SART1259, SNRNP110, Snu66
  • Links
    NCBI Gene ID: 9092
    neXtProt AC: NX_O43290
    UniProt: O43290

  • Chr Location
    11q13.1; chr11:65961689-65980136 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039148 Ensembl Gene Model | MGI Sequence Detail 11181 C57BL/6J ±  kb
    transcript ENSMUST00000044207 Ensembl | MGI Sequence Detail 5091 Not Applicable  
    polypeptide ENSMUSP00000047397 Ensembl | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 93
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:49838 Gotoh M, et al., Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Jpn J Cancer Res. 1998 Aug;89(8):849-54
    • Latest
      J:241191 Koh MY, et al., A new HIF-1alpha/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology. 2016 May;63(5):1576-91

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory