Sart1 MGI Mouse Gene Detail - MGI:1309453 - squamous cell carcinoma antigen recognized by T cells 1

Symbol

Sart1
Name

squamous cell carcinoma antigen recognized by T cells 1
Synonyms

U5-110K

Feature Type

protein coding gene
IDs

MGI:1309453
NCBI Gene: 20227
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:5427551-5438731 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.31 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

28 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1309453	protein coding gene	Chr19:5427551-5438731 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024702	protein coding gene	Chr19:2334993-2348007 (-)
A/J	MGP_AJ_G0024668	protein coding gene	Chr19:2210766-2221716 (-)
AKR/J	MGP_AKRJ_G0024641	protein coding gene	Chr19:2272640-2283590 (-)
BALB/cJ	MGP_BALBcJ_G0024668	protein coding gene	Chr19:2206861-2217811 (-)
C3H/HeJ	MGP_C3HHeJ_G0024436	protein coding gene	Chr19:2278393-2289343 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025115	protein coding gene	Chr19:2394865-2407915 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022545	protein coding gene	Chr19:2117038-2128064 (-)
CAST/EiJ	MGP_CASTEiJ_G0023908	protein coding gene	Chr19:2307515-2319720 (-)
CBA/J	MGP_CBAJ_G0024408	protein coding gene	Chr19:2500396-2511702 (-)
DBA/2J	MGP_DBA2J_G0024535	protein coding gene	Chr19:2190660-2201968 (-)
FVB/NJ	MGP_FVBNJ_G0024502	protein coding gene	Chr19:2198131-2209089 (-)
LP/J	MGP_LPJ_G0024621	protein coding gene	Chr19:2318120-2330819 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024532	protein coding gene	Chr19:2352241-2363191 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025163	protein coding gene	Chr19:2273695-2286308 (-)
PWK/PhJ	MGP_PWKPhJ_G0023654	protein coding gene	Chr19:2228439-2239434 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023459	protein coding gene	Chr19:2264160-2275099 (-)
WSB/EiJ	MGP_WSBEiJ_G0023970	protein coding gene	Chr19:2291074-2302032 (-)

Human Ortholog

SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
Synonyms

Ara1, HAF, HOMS1, SART1259, SNRNP110, Snu66
Links

HGNC:10538

NCBI Gene ID: 9092

neXtProt AC: NX_O43290

UniProt: O43290
Chr Location

11q13.1; chr11:65961728-65980137 (+) GRCh38

MGI Vertebrate Homology

Sart1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SART1
Gene Tree

Sart1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

19
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

109
cDNA Data

90
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sart1

ZFIN sart1

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All Sequences

43
RefSeq

4
UniProt

2
CCDS

CCDS29460.1

Ensembl

ENSMUSG00000039148 (Evidence)
NCBI Gene

20227

			Length	Strain/Species	Flank
genomic	20227	NCBI Gene Model \| MGI Sequence Detail	11181	C57BL/6J	± kb
transcript	NM_016882	RefSeq \| MGI Sequence Detail	5091	Not Specified
polypeptide	Q9Z315	UniProt \| EBI \| MGI Sequence Detail	806	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014461 U4/U6.U5 tri-snRNP-associated protein 1

(term hierarchy)
InterPro Domains

IPR045347 HIND motif

IPR005011 SNU66/SART1 family

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All nucleic 94

cDNA 93

Primer pair 1

Microarray probesets 5

Summaries

All 39

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 10
Earliest

J:49838 Gotoh M, et al., Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Jpn J Cancer Res. 1998 Aug;89(8):849-54
Latest

J:241191 Koh MY, et al., A new HIF-1alpha/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology. 2016 May;63(5):1576-91

TSS for Sart1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157583	Chr19:5439952-5439970 (-)	-1,230 bp
Tssr157582	Chr19:5438754-5438763 (-)	-28 bp
Tssr157581	Chr19:5438684-5438719 (-)	29 bp
Tssr157580	Chr19:5438657-5438669 (-)	68 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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