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Sart1 Gene Detail
Summary
  • Symbol
    Sart1
  • Name
    squamous cell carcinoma antigen recognized by T cells 1
  • Synonyms
    U5-110K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309453
    NCBI Gene: 20227
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5427551-5438731 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.31 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309453
 protein coding gene Chr19:5427551-5438731 (-)
129S1/SvImJ ENSMUSG00200043246
 protein coding gene Chr19:2189466-2200646 (-)
A/J ENSMUSG00195052820
 protein coding gene Chr19:2585800-2596750 (-)
AKR/J ENSMUSG00220032812
 protein coding gene Chr19:2358914-2369864 (-)
BALB/cJ ENSMUSG00180050033
 protein coding gene Chr19:2960524-2971474 (-)
C3H/HeJ ENSMUSG00175009926
 protein coding gene Chr19:2210731-2221681 (-)
C57BL/6NJ ENSMUSG00215034113
 protein coding gene Chr19:2427662-2438843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022545
 protein coding gene Chr19:2117038-2128064 (-)
CAST/EiJ ENSTCUG00005041174
 protein coding gene Chr19:2351006-2361984 (-)
CBA/J ENSMUSG00210048639
 protein coding gene Chr19:2211049-2222230 (-)
DBA/2J ENSMUSG00185043439
 protein coding gene Chr19:2587505-2598686 (-)
FVB/NJ ENSMUSG00205049865
 protein coding gene Chr19:2591449-2602407 (-)
JF1/MsJ ENSUMUG00000013556
 protein coding gene Chr19:2566872-2577866 (-)
LP/J ENSMUSG00230052467
 protein coding gene Chr19:3496386-3507566 (-)
NOD/ShiLtJ ENSMUSG00190050628
 protein coding gene Chr19:2120314-2131264 (-)
NZO/HlLtJ ENSMUSG00225026338
 protein coding gene Chr19:7205154-7216334 (-)
PWK/PhJ ENSLUMG00010003248
 protein coding gene Chr19:2335825-2346820 (-)
SPRET/EiJ ENSMSPG00010046501
 protein coding gene Chr19:2323339-2334325 (-)
WSB/EiJ ENSIUOG00005050284
 protein coding gene Chr19:2223284-2234242 (-)



Homology
more
  • Human Ortholog
    SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SART1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  • Synonyms
    Ara1, HAF, HOMS1, SART1259, SNRNP110, Snu66
  • Links
    NCBI Gene ID: 9092
    UniProt: O43290

  • Chr Location
    11q13.1; chr11:65961689-65980137 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sart1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality during organogenesis with decreased body size and vascularization. Heterozygous null male mice display hepatic steatosis and hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    109
  • cDNA Data
    90
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20227 NCBI Gene Model | MGI Sequence Detail 11181 C57BL/6J ±  kb
    transcript NM_016882 RefSeq | MGI Sequence Detail 5091 Not Specified  
    polypeptide Q9Z315 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 93
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:49838 Gotoh M, et al., Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Jpn J Cancer Res. 1998 Aug;89(8):849-54
    • Latest
      J:373046 Acuna-Pilarte K, et al., HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-kappaB pathway. Hepatology. 2025 Aug 1;82(2):438-453
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory