Analysis Tools
liver/biliary system
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• Kupffer cell hyperplasia in 6 of 6 livers at 14-18 months of age
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• increase in average liver weight to body weight ratios
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• mild to moderate microvesicular hepatic steatosis with increased severity in the lobular/periacinar and midzonal regions in males at 6 months of age
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• liver tumors detected by MRI in 57% (4 of 7) males at age 16-18 months of age but not in males under 10 months of age
• preneoplastic foci composed of hypertrophic or cytomegalic hepatocytes showing increased proliferation are present at 6 months of age in males
• treatment with a CCL5-neutralizing antibody for 5 weeks suppressed the development of new liver nodules
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• in 83% of males (5 of 6) multifocal large liver tumors, confirmed to be hepatocellular carcinomas (HCC), are found at necropsy
• in males livers show hallmarks of NASH-driven hepatocellular carcinoma with steatosis, fibrosis, and foci of immune cell infiltration
• livers of age matched females show minimal steatosis and no malignant tumors
• at 10 months of age, HCC is detected in 5 of 12 mice and preneoplastic foci are seen in 83% of mice
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• in males over 14 months of age with tumors
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• Kupffer cells show higher levels of secreted cytokines with a 100% increase in CCL5 secretion in mice over 6 months of age
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• foci of immune cell infiltration in males over 14 months of age with tumors
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• defects in fatty acid oxidation with an almost 4-fold decrease in the ability to utilize exogenous palmitate in hepatocytes from 4 month old mice
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immune system
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• Kupffer cell hyperplasia in 6 of 6 livers at 14-18 months of age
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• 6-fold increase in Ly6G+ neutrophils in the livers of male mice at 6 months of age
• 3-fold increase in Ly6G+ neutrophils in the livers of male mice at 1 months of age
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• elevated Hif1a expression in liver infiltrating immune cells
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• 100% increase in CCL5 secretion in Kupffer cells in mice over 6 months of age
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• foci of immune cell infiltration in males over 14 months of age with tumors
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growth/size/body
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• at over 14 months of age males are significantly smaller compared to wild-type controls
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• increase in average liver weight to body weight ratios
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homeostasis/metabolism
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• at 6 months of age
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• at 6 months of age
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• at 6 months of age
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integument
ruffled hair
(
J:241191
)
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• in males at over 14 months of age
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neoplasm
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• liver tumors detected by MRI in 57% (4 of 7) males at age 16-18 months of age but not in males under 10 months of age
• preneoplastic foci composed of hypertrophic or cytomegalic hepatocytes showing increased proliferation are present at 6 months of age in males
• treatment with a CCL5-neutralizing antibody for 5 weeks suppressed the development of new liver nodules
|
|
|
• in 83% of males (5 of 6) multifocal large liver tumors, confirmed to be hepatocellular carcinomas (HCC), are found at necropsy
• in males livers show hallmarks of NASH-driven hepatocellular carcinoma with steatosis, fibrosis, and foci of immune cell infiltration
• livers of age matched females show minimal steatosis and no malignant tumors
• at 10 months of age, HCC is detected in 5 of 12 mice and preneoplastic foci are seen in 83% of mice
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cardiovascular system
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• Kupffer cell hyperplasia in 6 of 6 livers at 14-18 months of age
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hematopoietic system
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• Kupffer cell hyperplasia in 6 of 6 livers at 14-18 months of age
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• 6-fold increase in Ly6G+ neutrophils in the livers of male mice at 6 months of age
• 3-fold increase in Ly6G+ neutrophils in the livers of male mice at 1 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:241191 | |
