About   Help   FAQ
Sncg Gene Detail
Summary
  • Symbol
    Sncg
  • Name
    synuclein, gamma
  • Synonyms
    C79089, persyn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298397
    NCBI Gene: 20618
  • Gene Overview
    MyGene.info: SNCG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:34370274-34374789 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4516 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.81 cM, cytoband B-C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SNCG, synuclein gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SNCG, synuclein gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCSG1, SR
  • Links
    NCBI Gene ID: 6623
    neXtProt AC: NX_O76070
    UniProt: O76070

  • Chr Location
    10q23.2; chr10:86958531-86963260 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2322
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SNCG
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sncg mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and show no morphological or functional abnormalities of the nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034011 VEGA Gene Model | MGI Sequence Detail 4516 C57BL/6J ±  kb
    transcript OTTMUST00000085864 VEGA | MGI Sequence Detail 852 Not Applicable  
    polypeptide OTTMUSP00000046435 VEGA | MGI Sequence Detail 123 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      107 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 3
      cDNA 42
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1353613
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:49830 Buchman VL, et al., Persyn, a member of the synuclein family, influences neurofilament network integrity. Nat Neurosci. 1998 Jun;1(2):101-3
    • Latest
      J:251123 Vargas KJ, et al., Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep. 2017 Jan 3;18(1):161-173

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory