Ncoa1
Gene Detail

Symbol Name ID

Ncoa1 nuclear receptor coactivator 1 MGI:1276523

Synonyms

bHLHe74, KAT13A, SRC1, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

2.05 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:4247363-4477182 bp, - strand From Ensembl annotation of GRCm38   229820 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa1

Human homologs

Human Homolog		NCOA1, nuclear receptor coactivator 1
NCBI Gene ID		8648
neXtProt AC		NX_Q15788
Human Synonyms		bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1
Human Chr (Location)		2p23; chr2:24807346-24993571 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(222) : Targeted(5) Gene trapped(217)
 

Homozygotes for a null allele show osteopenia, increased serum sex hormone levels, altered bone remodeling and skeletal responses to sex hormones, and obesity. Homozygotes for another null allele show thyroid and steroid hormone resistance, delayed Purkinje cell development, and behavioral deficits.

 
Human Diseases Modeled Using Mouse Ncoa1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	cellular response to hormone stimulus, histone H4 acetylation, ...
Component	cytoplasm, neuron projection, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (253)    Tissues (125)    Images (39)
Theiler Stages: 2, 3, 4, 5, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	192
RT-PCR	61

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(109) Genomic(1) cDNA(105) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000020647 (Evidence)
Entrez Gene	17977 (Evidence)
UniGene	301039
DFCI	TC1579668, TC1596579, TC1603951, TC1652824, TC1766809
DoTS	DT.101704802, DT.103593316, DT.529148, DT.91395343, DT.91437965
NIA Mouse Gene Index	U033762
EC	2.3.1.48
PDB	2O9I, 4DMA, 1OJ5
Consensus CDS Project	CCDS25789.1
International Mouse Knockout Project Status	Ncoa1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000020647	Ensembl Gene Model | MGI Sequence Detail	229820	C57BL/6J
transcript	ENSMUST00000085814	Ensembl | MGI Sequence Detail	7328	Not Applicable
polypeptide	ENSMUSP00000082971	Ensembl | MGI Sequence Detail	1405	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(632 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010011	Domain of unknown function DUF1518
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR017426	Nuclear receptor coactivator
InterPro	IPR009110	Nuclear receptor coactivator, interlocking
InterPro	IPR014920	Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro	IPR008955	Nuclear receptor coactivator Src-1
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
InterPro	IPR014935	Steroid receptor coactivator
Protein Ontology	PR:000011040	nuclear receptor coactivator 1

References

(Earliest) J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
(Latest) J:194628 Zhu L, et al., Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan;154(1):150-8
All references(112)