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Ncoa1
Gene Detail
 Symbol
Name
ID
Ncoa1
nuclear receptor coactivator 1
MGI:1276523
Synonyms bHLHe74, KAT13A, SRC1, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1
Feature Type protein coding gene
Genetic Map
Chromosome 12
2.05 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:4247363-4477182 bp, - strand
From Ensembl annotation of GRCm38

  229820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa1

Human
homologs
Human Homolog NCOA1, nuclear receptor coactivator 1
NCBI Gene ID 8648
neXtProt AC  NX_Q15788
Human Synonyms  bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1
Human Chr (Location)  2p23; chr2:24492050-24770702 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(223) : Gene trapped(217) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show osteopenia, increased serum sex hormone levels, altered bone remodeling and skeletal responses to sex hormones, and obesity. Homozygotes for another null allele show thyroid and steroid hormone resistance, delayed Purkinje cell development, and behavioral deficits.
 
Human Diseases Modeled Using Mouse Ncoa1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ncoa1 interacts with 424 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cellular response to hormone stimulus, histone H4 acetylation, ...
Component cytoplasm, neuron projection, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (247)    Tissues (125)    Images (39)
Theiler Stages: 2, 3, 4, 5, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 193
RT-PCR 54
cDNA source data(101)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(1) cDNA(104) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020647 (Evidence)
Entrez Gene17977 (Evidence)
UniGene301039
DFCITC1579668, TC1596579, TC1603951, TC1652824, TC1766809
DoTSDT.101704802, DT.103593316, DT.529148, DT.91395343, DT.91437965
NIA Mouse Gene IndexU033762
EC2.3.1.48
PDB2O9I, 4DMA, 1OJ5
Consensus CDS ProjectCCDS25789.1
International Mouse Knockout Project StatusNcoa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020647 Ensembl Gene Model | MGI Sequence Detail 229820 C57BL/6J ±  kb
transcript ENSMUST00000085814 Ensembl | MGI Sequence Detail 7328 Not Applicable 
polypeptide ENSMUSP00000082971 Ensembl | MGI Sequence Detail 1405 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(754 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010011 Domain of unknown function DUF1518
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR017426 Nuclear receptor coactivator
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro IPR008955 Nuclear receptor coactivator Src-1
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR014935 Steroid receptor coactivator
Protein Ontology PR:000011040 nuclear receptor coactivator 1
References (Earliest) J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
(Latest) J:210822 Walsh CA, et al., Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis. Cancer Res. 2014 May 1;74(9):2533-44
All references(116)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory