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Ncoa1
Gene Detail
Symbol

Name
ID
Ncoa1
nuclear receptor coactivator 1
MGI:1276523
Synonyms
bHLHe74, KAT13A, SRC1, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
2.05 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:4247363-4477182 bp, - strand
From Ensembl annotation of GRCm38

  229820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NCOA1
Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa1

Human
homologs
NCOA1, nuclear receptor coactivator 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8648
neXtProt AC: NX_Q15788

Human Synonyms: bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1

Human Chr (Location): 2p23; chr2:24492050-24770702 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(224) : Gene trapped(217) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null allele show osteopenia, increased serum sex hormone levels, altered bone remodeling and skeletal responses to sex hormones, and obesity. Homozygotes for another null allele show thyroid and steroid hormone resistance, delayed Purkinje cell development, and behavioral deficits.
 
Human Diseases Modeled in Mice Using Ncoa1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ncoa1 interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process cellular response to hormone stimulus, cellular response to Thyroglobulin triiodothyronine, ...
Component cytoplasm, neuron projection, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (247)    Tissues (125)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 54
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NCOA1 ; Xenbase ncoa1 ; ZFIN ncoa1    NEW 
Molecular
reagents
All nucleic(108) Genomic(1) cDNA(104) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000020647 (Evidence)
Entrez Gene 17977 (Evidence)
UniGene 301039
DFCI TC1603951, TC1596579, TC1766809, TC1652824, TC1579668
DoTS DT.529148, DT.91395343, DT.103593316, DT.101704802, DT.91437965
NIA Mouse Gene Index U033762
EC 2.3.1.48
PDB 4DMA, 2O9I, 1OJ5
Consensus CDS Project CCDS25789.1
International Mouse Phenotyping Consortium Status Ncoa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020647 Ensembl Gene Model | MGI Sequence Detail 229820 C57BL/6J ±  kb
transcript ENSMUST00000085814 Ensembl | MGI Sequence Detail 7328 Not Applicable 
polypeptide ENSMUSP00000082971 Ensembl | MGI Sequence Detail 1405 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(754 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010011 Domain of unknown function DUF1518
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR017426 Nuclear receptor coactivator
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro IPR008955 Nuclear receptor coactivator Src-1
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR014935 Steroid receptor coactivator
Protein Ontology PR:000011040 nuclear receptor coactivator 1
References
(Earliest) J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
(Latest) J:216303 Tannour-Louet M, et al., Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. Mol Endocrinol. 2014 Oct;28(10):1707-18
All references(120)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory