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Phenotypes Associated with This Genotype
Genotype
MGI:3527794
Allelic
Composition
Ncoa1tm1Bwo/Ncoa1tm1Bwo
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1tm1Bwo mutation (0 available); any Ncoa1 mutation (169 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• less decidual response to mechanical stimulation
• reduced response to estrogen treatment
• growth reduced about 34% in castrated males after testosterone treatment
• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio

homeostasis/metabolism
• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice

endocrine/exocrine glands
• ductal development only about half normal at 8 weeks of age
• alveoli much less developed
• growth reduced about 34% in castrated males after testosterone treatment
• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio

behavior/neurological
• increased escape latency in a Morris water maze
• slower swim speed
• tended to fall in a hanging wire test about 29% earlier than controls
• shorter latency to falling in a rotarod test and less improvement with repeated testing

nervous system
• absent at birth
• gradually reached normal levels by about age 10 days
• development of Purkinje cell precursors delayed from E10.5 to around E12.5

embryo
• reduced response to estrogen treatment
• less decidual response to mechanical stimulation

integument
• ductal development only about half normal at 8 weeks of age
• alveoli much less developed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid hormone resistance syndrome DOID:11633 OMIM:188570
OMIM:274300
J:54182


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory