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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ncoa1
nuclear receptor coactivator 1
MGI:1276523
43 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ncoa1tm1.1(KOMP)Vlcg/Ncoa1tm1.1(KOMP)Vlcg
C57BL/6N-Ncoa1tm1.1(KOMP)Vlcg/Ucd 		abnormal brain morphology J:211773
decreased fasting circulating glucose level J:211773
decreased total body fat amount J:211773
hydrocephaly J:211773
hyperactivity J:211773
increased bone mineral content J:211773
increased circulating alkaline phosphatase level J:211773
increased grip strength J:211773
increased lean body mass J:211773
Ncoa1tm1.1Hkaw/Ncoa1tm1.1Hkaw
B6.Cg-Ncoa1tm1.1Hkaw 		abnormal bone remodeling J:111490
abnormal urine homeostasis J:111490
decreased bone mineral content J:111490
decreased bone mineral density J:111490
decreased bone mineral density of femur J:111490
decreased bone volume J:111490
decreased circulating testosterone level J:111490
increased bone resorption J:111490
increased circulating alkaline phosphatase level J:111490
increased circulating estradiol level J:111490
increased circulating leptin level J:111490
obese J:111490
osteoporosis J:111490
testis hypoplasia J:111490
Ncoa1tm1Bwo/Ncoa1tm1Bwo
involves: 129 * C57BL/6 		normal reproductive system phenotype J:101966
Ncoa1tm1Bwo/Ncoa1tm1Bwo
involves: 129 * C57BL/6J 		normal immune system phenotype J:109522
Ncoa1tm1Bwo/Ncoa1tm1Bwo
involves: 129/Sv * C57BL/6 		abnormal cerebellar Purkinje cell layer J:81201
abnormal cerebellum morphology J:81201
abnormal decidualization J:46528
abnormal female reproductive system morphology J:46528
abnormal male reproductive system morphology J:46528
abnormal mammary gland development J:46528
abnormal Purkinje cell morphology J:81201
abnormal response/metabolism to endogenous compounds J:126521
abnormal spatial learning J:81201
abnormal thyroid hormone level J:54182
impaired coordination J:81201
increased circulating thyroid-stimulating hormone level J:54182, J:126521
increased circulating thyroxine level J:126521
increased circulating triiodothyronine level J:126521
increased thyroxine level J:54182
increased triiodothyronine level J:54182
small prostate gland J:46528
small testis J:46528
Ncoa1tm1Hkaw/Ncoa1tm1Hkaw
involves: C57BL/6J 		no abnormal phenotype detected J:111490
Ncoa1tm1Jkr/Ncoa1tm1Jkr
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:53063
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory