Ncoa1^tm1Jkr
Targeted Allele Detail

Summary

• Symbol: Ncoa1^tm1Jkr
• Name: nuclear receptor coactivator 1; targeted mutation 1, Janardan K Reddy
• MGI ID: MGI:3641219
• Synonyms: SRC-1^-
• Gene: Ncoa1 Location: Chr12:4297362-4527182 bp, - strand Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
• Alliance: Ncoa1^tm1Jkr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53063
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace most of exon B with a neomycin resistance cassette. RT-PCR confirmed absence of transcript in mutant kidney, liver and colon samples. Northern and Western blot analyses confirmed ablation of the locus. (J:53063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa1 Mutation: 169 strains or lines available

References

• Original: J:53063 Qi C, et al., Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1585-90
• All: 7 reference(s)