Ep300
Gene Detail

Symbol Name ID

Ep300 E1A binding protein p300 MGI:1276116

Synonyms

KAT3B, p300

Feature Type

protein coding gene

Genetic Map

Chromosome 15

38.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:81586214-81652077 bp, + strand From NCBI annotation of GRCm38   65864 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Ep300

Human homologs

Human Homolog		EP300, E1A binding protein p300
NCBI Gene ID		2033
neXtProt AC		NX_Q09472
Human Synonyms		KAT3B, p300, RSTS2
Human Chr (Location)		22q13.2; chr22:41488614-41576081 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human EP300

Alleles and phenotypes

All alleles(36) : Targeted(8) Gene trapped(27) Chemically induced(1)
 

Homozygotes for a targeted null mutation exhibit defects of the heart, lung, and small intestine and die at midgestation; heterozygotes also show some embryonic loss. Heterozygotes for an acetyltransferase-negative mutation die by the neonatal period.

 
Human Diseases Modeled Using Mouse Ep300 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (125 annotations)

Process	apoptotic process, cartilage development, ...
Component	chromatin, cytoplasm, ...
Function	acetyltransferase activity, activating transcription factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (18)    Tissues (13)    Images (2)
Theiler Stages: 5, 11, 15, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	7
Northern blot	6
RT-PCR	3

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(1) cDNA(31) Primer pair(2) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000055024 (Evidence)
Entrez Gene	328572 (Evidence)
NIA Mouse Gene Index	U016465
EC	2.3.1.48
Consensus CDS Project	CCDS37149.1
International Mouse Knockout Project Status	Ep300

Sequences

Length	Strain/Species
genomic	328572	NCBI Gene Model | MGI Sequence Detail	65864	C57BL/6J
transcript	NM_177821	RefSeq | MGI Sequence Detail	8749	C57BL/6
polypeptide	B2RWS6	UniProt | EBI | MGI Sequence Detail	2415	Not Applicable

All sequences(45) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR003101	Coactivator CBP, KIX domain
InterPro	IPR010303	Domain of unknown function DUF902, CREBbp
InterPro	IPR013178	Histone H3-K56 acetyltransferase, RTT109
InterPro	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro	IPR009110	Nuclear receptor coactivator, interlocking
InterPro	IPR000197	Zinc finger, TAZ-type
InterPro	IPR000433	Zinc finger, ZZ-type
Protein Ontology	PR:000007102	histone acetyltransferase p300

Graphical View of Protein Domain Structure

References

(Earliest) J:65047 Missero C, et al., Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation. J Cell Biol. 1993 Jun;121(5):1109-20
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(130)