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Ep300
Gene Detail
Symbol

Name
ID
Ep300
E1A binding protein p300
MGI:1276116
Synonyms
KAT3B, p300
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:81585351-81652072 bp, + strand
From VEGA annotation of GRCm38

  66722 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: EP300
Gene Tree: Ep300

Human
homologs
EP300, E1A binding protein p300
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2033
neXtProt AC: NX_Q09472

Human Synonyms: KAT3B, p300, RSTS2

Human Chr (Location): 22q13.2; chr22:41092610-41180077 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EP300

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Chemically induced (ENU)(1) Gene trapped(31) Radiation induced(1) Targeted(10)
Genomic Mutations involving Ep300 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit defects of the heart, lung, and small intestine and die at midgestation; heterozygotes also show some embryonic loss. Heterozygotes for an acetyltransferase-negative mutation die by the neonatal period.
 
Human Diseases Modeled in Mice Using Ep300 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Ep300 interacts with 340 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (164 annotations)
Process apoptotic process, cartilage development, ...
Component chromatin, cytoplasm, ...
Function acetyltransferase activity, activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (30)    Tissues (14)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
Northern blot 6
Western blot 12
RT-PCR 3
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ep300 ; ZFIN ep300a, ep300b    NEW 
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(31) Primer pair(2) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000048223 (Evidence)
Ensembl Gene Model ENSMUSG00000055024 (Evidence)
Entrez Gene 328572 (Evidence)
NIA Mouse Gene Index U016465
EC 2.3.1.48
Consensus CDS Project CCDS37149.1
International Mouse Phenotyping Consortium Status Ep300
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048223 VEGA Gene Model | MGI Sequence Detail 66722 C57BL/6J ±  kb
transcript OTTMUST00000123794 VEGA | MGI Sequence Detail 8738 Not Applicable 
polypeptide OTTMUSP00000067505 VEGA | MGI Sequence Detail 2412 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR003101 Coactivator CBP, KIX domain
InterPro IPR010303 Domain of unknown function DUF902, CREBbp
InterPro IPR013178 Histone H3-K56 acetyltransferase, RTT109
InterPro IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR000197 Zinc finger, TAZ-type
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000007102 histone acetyltransferase p300
References
(Earliest) J:65047 Missero C, et al., Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation. J Cell Biol. 1993 Jun;121(5):1109-20
(Latest) J:214218 Tollini LA, et al., Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell. 2014 Aug 11;26(2):235-47
All references(153)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory