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Ep300
Gene Detail
Symbol

Name
ID
Ep300
E1A binding protein p300
MGI:1276116
Synonyms
KAT3B, p300
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:81585351-81652072 bp, + strand
From VEGA annotation of GRCm38

  66722 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1094  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Gene Tree: Ep300

Human
homologs
Human Homolog EP300, E1A binding protein p300
NCBI Gene ID 2033
neXtProt AC  NX_Q09472
Human Synonyms  KAT3B, p300, RSTS2
Human Chr (Location)  22q13.2; chr22:41092302-41180083 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human EP300
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Chemically induced (ENU)(1) Gene trapped(31) Radiation induced(1) Targeted(8)
Genomic Mutations involving Ep300 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defects of the heart, lung, and small intestine and die at midgestation; heterozygotes also show some embryonic loss. Heterozygotes for an acetyltransferase-negative mutation die by the neonatal period.
 
Human Diseases Modeled Using Mouse Ep300 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ep300 interacts with 341 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (153 annotations)
Process apoptotic process, cartilage development, ...
Component chromatin, cytoplasm, ...
Function acetyltransferase activity, activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (30)    Tissues (14)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
Northern blot 6
Western blot 12
RT-PCR 3
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(31) Primer pair(2) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000048223 (Evidence)
Ensembl Gene ModelENSMUSG00000055024 (Evidence)
Entrez Gene328572 (Evidence)
NIA Mouse Gene IndexU016465
EC2.3.1.48
Consensus CDS ProjectCCDS37149.1
International Mouse Knockout Project StatusEp300
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048223 VEGA Gene Model | MGI Sequence Detail 66722 C57BL/6J ±  kb
transcript OTTMUST00000123794 VEGA | MGI Sequence Detail 8738 Not Applicable 
polypeptide OTTMUSP00000067505 VEGA | MGI Sequence Detail 2412 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR003101 Coactivator CBP, KIX domain
InterPro IPR010303 Domain of unknown function DUF902, CREBbp
InterPro IPR013178 Histone H3-K56 acetyltransferase, RTT109
InterPro IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR000197 Zinc finger, TAZ-type
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000007102 histone acetyltransferase p300
References
(Earliest) J:65047 Missero C, et al., Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation. J Cell Biol. 1993 Jun;121(5):1109-20
(Latest) J:214218 Tollini LA, et al., Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell. 2014 Aug 11;26(2):235-47
All references(147)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory