Sequence Detail

ID/Version

B2RWS6 E9PYJ8 (UniProt | EBI)

Last sequence update: 2014-04-16
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Histone acetyltransferase p300; Short=p300 HAT; EC=2.3.1.48 {ECO:0000269|PubMed:27105113};AltName: Full=E1A-associated protein p300;AltName: Full=Histone butyryltransferase p300; EC=2.3.1.- {ECO:0000269|PubMed:2710511

Provider

SWISS-PROT

Sequence

Polypeptide 2412 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ep300	E1A binding protein p300	259	122	4	43

Sequence references in MGI

J:61379 Yahata T, et al., The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34
J:95385 Cao D, et al., Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76
J:112873 Aikawa Y, et al., Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006 Sep 6;25(17):3955-65
J:132209 Mehra-Chaudhary R, et al., Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem J. 2001 Jan 1;353(Pt 1):13-22
J:148702 Ohoka N, et al., The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol. 2009 Jun;23(6):759-71
J:164308 Zhang M, et al., p300-mediated acetylation stabilizes the Th-inducing POK factor. J Immunol. 2010 Oct 1;185(7):3960-9
J:172915 Glenn DJ, et al., MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem. 1999 Dec 17;274(51):36159-67
J:172919 Mutoh H, et al., The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15;12(6):820-30
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:207820 Curtis AM, et al., Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7
J:215876 Wang FM, et al., Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem J. 2011 Jan 1;433(1):245-52
J:219094 Cesena TI, et al., Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol Cell Endocrinol. 2008 Jul 16;289(1-2):94-101
J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90
J:224721 Zhao Y, et al., p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation. Mol Cell Biol. 2014 Feb;34(3):315-24
J:243518 Goudarzi A, et al., Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 2016 Apr 21;62(2):169-80
J:272987 Ryu D, et al., A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metab. 2014 Nov 4;20(5):856-869
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89