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Cldn5
Gene Detail
 Symbol
Name
ID
Cldn5
claudin 5
MGI:1276112
Synonyms Tmvcf
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:18776847-18778260 bp, + strand
From Ensembl annotation of GRCm38

  1414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2459  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cldn5

Human
homologs
Human Homolog CLDN5, claudin 5
NCBI Gene ID 7122
neXtProt AC  NX_O00501
Human Synonyms  AWAL, BEC1, CPETRL1, TMVCF
Human Chr (Location)  22q11.21; chr22:19523024-19527545 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Cldn5 (3)
 
Homozygous mutation of this gene results in size-selective loosening of the blood-brain barrier. Homozygous mutant neonates gradually cease movement and die within 10 hours after birth.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Cldn5 interacts with 76 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process myelination, single organismal cell-cell adhesion
Component cell-cell junction, cell junction, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (150)    Tissues (104)    Images (31)
Theiler Stages: 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 93
Northern blot 12
Western blot 1
RT-PCR 35
cDNA source data(61)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(82) Genomic(15) cDNA(63) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000041378 (Evidence)
Entrez Gene12741 (Evidence)
UniGene22768
DFCITC1578997
DoTSDT.534942
NIA Mouse Gene IndexU016899
Consensus CDS ProjectCCDS28026.1
International Mouse Knockout Project StatusCldn5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041378 Ensembl Gene Model | MGI Sequence Detail 1414 C57BL/6J ±  kb
transcript ENSMUST00000043577 Ensembl | MGI Sequence Detail 1414 Not Applicable 
polypeptide ENSMUSP00000041925 Ensembl | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003551 Claudin-5
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005553 claudin-5
References (Earliest) J:41222 Sirotkin H, et al., Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Genomics. 1997 Jun 1;42(2):245-51
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(83)
Other
accession IDs
MGI:1095399, MGI:2146515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory