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Cldn5
Gene Detail
Symbol

Name
ID
Cldn5
claudin 5
MGI:1276112
Synonyms
Tmvcf
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:18776847-18778260 bp, + strand
From Ensembl annotation of GRCm38

  1414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2459  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CLDN5
Gene Tree: Cldn5

Human
homologs
CLDN5, claudin 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7122
neXtProt AC: NX_O00501

Human Synonyms: AWAL, BEC1, CPETRL1, TMVCF

Human Chr (Location): 22q11.21; chr22:19523024-19525337 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Cldn5 (5)
 
Homozygous mutation of this gene results in size-selective loosening of the blood-brain barrier. Homozygous mutant neonates gradually cease movement and die within 10 hours after birth.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Cldn5 interacts with 76 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process myelination, single organismal cell-cell adhesion
Component bicellular tight junction, cell-cell junction, ...
Function protein binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (158)    Tissues (109)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 97
Northern blot 12
Western blot 1
RT-PCR 35
cDNA source data(62)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cldn5 ; ZFIN cldn5a, cldn5b    NEW 
Molecular
reagents
All nucleic(83) Genomic(15) cDNA(64) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000041378 (Evidence)
Entrez Gene 12741 (Evidence)
UniGene 22768
DFCI TC1578997
DoTS DT.534942
NIA Mouse Gene Index U016899
Consensus CDS Project CCDS28026.1
International Mouse Phenotyping Consortium Status Cldn5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041378 Ensembl Gene Model | MGI Sequence Detail 1414 C57BL/6J ±  kb
transcript ENSMUST00000043577 Ensembl | MGI Sequence Detail 1414 Not Applicable 
polypeptide ENSMUSP00000041925 Ensembl | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003551 Claudin-5
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005553 claudin-5
References
(Earliest) J:41222 Sirotkin H, et al., Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Genomics. 1997 Jun 1;42(2):245-51
(Latest) J:220912 Knowland D, et al., Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron. 2014 May 7;82(3):603-17
All references(88)
Other
accession IDs
MGI:1095399, MGI:2146515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory