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Dnmt3a Gene Detail
Summary
  • Symbol
    Dnmt3a
  • Name
    DNA methyltransferase 3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261827
    NCBI Gene: 13435
  • Gene Overview
    MyGene.info: DNMT3A
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:3806007-3914443 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.99 cM, cytoband A2-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261827
protein coding gene Chr12:3804986-3914443 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019559
protein coding gene Chr12:640910-750957 (+)
A/J MGP_AJ_G0019526
protein coding gene Chr12:679760-790171 (+)
AKR/J MGP_AKRJ_G0019496
protein coding gene Chr12:818499-932837 (+)
BALB/cJ MGP_BALBcJ_G0019501
protein coding gene Chr12:705992-820360 (+)
C3H/HeJ MGP_C3HHeJ_G0019307
protein coding gene Chr12:594599-714471 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019951
protein coding gene Chr12:653616-773982 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017575
protein coding gene Chr12:601902-701962 (+)
CAST/EiJ MGP_CASTEiJ_G0018862
protein coding gene Chr12:656562-767162 (+)
CBA/J MGP_CBAJ_G0019278
protein coding gene Chr12:896128-1007255 (+)
DBA/2J MGP_DBA2J_G0019391
protein coding gene Chr12:623938-732768 (+)
FVB/NJ MGP_FVBNJ_G0019382
protein coding gene Chr12:646847-753574 (+)
LP/J MGP_LPJ_G0019462
protein coding gene Chr12:665092-770467 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019415
protein coding gene Chr12:712925-823717 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019989
protein coding gene Chr12:595137-711392 (+)
PWK/PhJ MGP_PWKPhJ_G0018628
protein coding gene Chr12:632779-739647 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0018914
protein coding gene Chr12:630643-740995 (+)



Homology
more
  • Human Ortholog
    DNMT3A, DNA methyltransferase 3 alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNMT3A, DNA methyltransferase 3 alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DNMT3A2, M.HsaIIIA, TBRS
  • Links
    NCBI Gene ID: 1788
    neXtProt AC: NX_Q9Y6K1
    UniProt: Q9Y6K1

  • Chr Location
    2p23.3; chr2:25232961-25342590 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DNMT3A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 7 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation become runted and die around four weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020661 Ensembl Gene Model | MGI Sequence Detail 108437 C57BL/6J ±  kb
    transcript ENSMUST00000020991 Ensembl | MGI Sequence Detail 9685 Not Applicable  
    polypeptide ENSMUSP00000020991 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 37
      Primer pair 14
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144939, MGI:2145138
    References
    more
    • Summaries
      All 243
      Developmental Gene Expression 59
      Diseases 1
      Gene Ontology 24
      Phenotypes 83
    • Earliest
      J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
    • Latest
      J:266522 Elsen GE, et al., The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory