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Dnmt3a
Gene Detail
Symbol

Name
ID
Dnmt3a
DNA methyltransferase 3A
MGI:1261827
Feature Type
protein coding gene
Genetic Map
Chromosome 12
1.99 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:3806007-3914443 bp, + strand
From VEGA annotation of GRCm38

  108437 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DNMT3A
Protein SuperFamily: DNA (cytosine-5)-methyltransferase 3B, Dnmt3b type
Gene Tree: Dnmt3a

Human
homologs
DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1788
neXtProt AC: NX_Q9Y6K1

Human Synonyms: DNMT3A2, M.HsaIIIA, TBRS

Human Chr (Location): 2p23; chr2:25232961-25342590 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNMT3A

Mutations,
alleles, and
phenotypes
All mutations/alleles(107) : Gene trapped(96) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation become runted and die around four weeks of age.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Dnmt3a interacts with 517 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component chromosome, centromeric region, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (824)    Tissues (619)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 626
Northern blot 15
Western blot 6
RT-PCR 146
cDNA source data(33)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DNMT3A ; Xenbase LOC100496503 ; ZFIN dnmt3aa, dnmt3ab    NEW 
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(35) Primer pair(12) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000037610 (Evidence)
Ensembl Gene Model ENSMUSG00000020661 (Evidence)
Entrez Gene 13435 (Evidence)
DFCI TC1574120, TC1611440, TC1614036, TC1666728, TC1680027, TC1721885
DoTS DT.101159993, DT.101403753, DT.490460, DT.491825, DT.94187734, DT.97363355, DT.97375072
NIA Mouse Gene Index U013709
EC 2.1.1.37
PDB 3SW9, 3SWC
Consensus CDS Project CCDS25784.1, CCDS36397.1
International Mouse Phenotyping Consortium Status Dnmt3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037610 VEGA Gene Model | MGI Sequence Detail 108437 C57BL/6J ±  kb
transcript OTTMUST00000097005 VEGA | MGI Sequence Detail 9685 Not Applicable 
polypeptide OTTMUSP00000054298 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(147) RefSeq(18) UniProt(14)
Polymorphisms
SNPs within 2kb(528 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025766 ADD domain
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR030487 DNA (cytosine-5)-methyltransferase 3A
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
InterPro IPR000313 PWWP domain
InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Protein Ontology PR:000006607 DNA (cytosine-5)-methyltransferase 3A
References
(Earliest) J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
(Latest) J:222088 Gabel HW, et al., Disruption of DNA-methylation-dependent long gene repression in Rett syndrome. Nature. 2015 Jun 4;522(7554):89-93
All references(169)
Other
accession IDs
MGI:2144939, MGI:2145138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory