Dnmt3a
Gene Detail

Symbol Name ID

Dnmt3a DNA methyltransferase 3A MGI:1261827

Feature Type

protein coding gene

Genetic Map

Chromosome 12

1.99 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:3806007-3914443 bp, + strand From VEGA annotation of GRCm38   108437 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA (cytosine-5)-methyltransferase 3B, Dnmt3b type
Gene Tree: Dnmt3a

Human homologs

Human Homolog		DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha
NCBI Gene ID		1788
neXtProt AC		NX_Q9Y6K1
Human Synonyms		DNMT3A2, M.HsaIIIA
Human Chr (Location)		2p23; chr2:25455830-25565459 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(107) : Targeted(10) Gene trapped(97)
 

Homozygotes for a targeted null mutation become runted and die around four weeks of age.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component	chromosome, centromeric region, cytoplasm, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (280)    Tissues (177)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 15, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	29
RNA in situ	131
Northern blot	15
Western blot	6
RT-PCR	99

cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(1) cDNA(33) Primer pair(9) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000037610 (Evidence)
Ensembl Gene Model	ENSMUSG00000020661 (Evidence)
Entrez Gene	13435 (Evidence)
DFCI	TC1574120, TC1611440, TC1614036, TC1666728, TC1680027, TC1721885
DoTS	DT.101159993, DT.101403753, DT.490460, DT.491825, DT.94187734, DT.97363355, DT.97375072
NIA Mouse Gene Index	U013709
EC	2.1.1.37
PDB	3SWC, 3SW9
Consensus CDS Project	CCDS25784.1, CCDS36397.1
International Mouse Knockout Project Status	Dnmt3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037610	VEGA Gene Model | MGI Sequence Detail	108437	C57BL/6J
transcript	OTTMUST00000097005	VEGA | MGI Sequence Detail	9685	Not Applicable
polypeptide	OTTMUSP00000054298	VEGA | MGI Sequence Detail	908	Not Applicable

All sequences(135) RefSeq(6) UniProt(14)

Polymorphisms

SNPs(349 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025766	ADD domain
InterPro	IPR001525	C-5 cytosine methyltransferase
InterPro	IPR025811	DNA (cytosine-5)-methyltransferase 3
InterPro	IPR018117	DNA methylase, C-5 cytosine-specific, active site
InterPro	IPR000313	PWWP
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
Protein Ontology	PR:000006607	DNA (cytosine-5)-methyltransferase 3A

References

(Earliest) J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
(Latest) J:194075 Guenatri M, et al., Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013 Feb 1;140(3):562-72
All references(141)

Other accession IDs

MGI:2144939, MGI:2145138