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Dnmt3a
Gene Detail
 Symbol
Name
ID
Dnmt3a
DNA methyltransferase 3A
MGI:1261827
Feature Type protein coding gene
Genetic Map
Chromosome 12
1.99 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:3806007-3914443 bp, + strand
From VEGA annotation of GRCm38

  108437 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA (cytosine-5)-methyltransferase 3B, Dnmt3b type
Gene Tree: Dnmt3a

Human
homologs
Human Homolog DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha
NCBI Gene ID 1788
neXtProt AC  NX_Q9Y6K1
Human Synonyms  DNMT3A2, M.HsaIIIA
Human Chr (Location)  2p23; chr2:25228552-25342590 (-)  GRCh38
Alleles
and
phenotypes
All alleles(107) : Targeted(10) Gene trapped(97)
 
Homozygotes for a targeted null mutation become runted and die around four weeks of age.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component chromosome, centromeric region, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (838)    Tissues (620)    Images (52)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 13, 15, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 31
RNA in situ 627
Northern blot 15
Western blot 6
RT-PCR 159
cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(35) Primer pair(12) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000037610 (Evidence)
Ensembl Gene ModelENSMUSG00000020661 (Evidence)
Entrez Gene13435 (Evidence)
DFCITC1574120, TC1611440, TC1614036, TC1666728, TC1680027, TC1721885
DoTSDT.101159993, DT.101403753, DT.490460, DT.491825, DT.94187734, DT.97363355, DT.97375072
NIA Mouse Gene IndexU013709
EC2.1.1.37
PDB3SWC, 3SW9
Consensus CDS ProjectCCDS25784.1, CCDS36397.1
International Mouse Knockout Project StatusDnmt3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037610 VEGA Gene Model | MGI Sequence Detail 108437 C57BL/6J ±  kb
transcript OTTMUST00000097005 VEGA | MGI Sequence Detail 9685 Not Applicable 
polypeptide OTTMUSP00000054298 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(16) UniProt(14)
Polymorphisms SNPs within 2kb(528 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025766 ADD domain
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR025811 DNA (cytosine-5)-methyltransferase 3
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
InterPro IPR000313 PWWP
Protein Ontology PR:000006607 DNA (cytosine-5)-methyltransferase 3A
References (Earliest) J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
(Latest) J:206847 Neri F, et al., Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013 Sep 26;155(1):121-34
All references(151)
Other
accession IDs
MGI:2144939, MGI:2145138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory