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Cd46
Gene Detail
Symbol

Name
ID
Cd46
CD46 antigen, complement regulatory protein
MGI:1203290
Synonyms
CD46, Mcp
Feature Type
protein coding gene
Genetic Map
Chromosome 1
98.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:195041238-195092249 bp, - strand
From VEGA annotation of GRCm38

  51012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD46
Protein SuperFamily: membrane cofactor protein, CD46 type
Gene Tree: Cd46

Human
homologs
CD46, CD46 molecule, complement regulatory protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4179
neXtProt AC: NX_P15529

Human Synonyms: AHUS2, MCP, MIC10, TLX, TRA2.10

Human Chr (Location): 1q32; chr1:207752038-207795516 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD46

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased litter sizes sired by mutant males. Another homozygous null mouse shows increased susceptibility to induced choroid neovascularization.
 
Interactions
Cd46 interacts with 114 markers (Mir16-2, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process interleukin-10 production, negative regulation of catalytic activity, ...
Component acrosomal vesicle, basolateral plasma membrane, ...
Function cadherin binding, complement binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 4
RT-PCR 2
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034956 (Evidence)
Ensembl Gene Model ENSMUSG00000016493 (Evidence)
Entrez Gene 17221 (Evidence)
UniGene 12884
DFCI TC1721915, TC1591205
DoTS DT.91588162, DT.55278892, DT.91335126
NIA Mouse Gene Index U022231
Consensus CDS Project CCDS35828.1
International Mouse Phenotyping Consortium Status Cd46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034956 VEGA Gene Model | MGI Sequence Detail 51012 C57BL/6J ±  kb
transcript OTTMUST00000088873 VEGA | MGI Sequence Detail 1876 Not Applicable 
polypeptide OTTMUSP00000048501 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(21) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(170 from dbSNP Build 137)    SNPs within 2kb including multiple locations(174)
Protein-related
information
ResourceIDDescription
InterPro IPR017341 Membrane cofactor protein, CD46
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001401 membrane cofactor protein
References
(Earliest) J:46287 Tsujimura A, et al., Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells. Biochem J. 1998 Feb 15;330(Pt 1):163-8
(Latest) J:213630 Lyzogubov V, et al., Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol. 2014 Sep;184(9):2537-48
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory