Cd46
Gene Detail

Symbol Name ID

Cd46 CD46 antigen, complement regulatory protein MGI:1203290

Synonyms

CD46, Mcp

Feature Type

protein coding gene

Genetic Map

Chromosome 1

98.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:195041285-195092248 bp, - strand From VEGA annotation of GRCm38   50964 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: membrane cofactor protein, CD46 type
Gene Tree: Cd46

Human homologs

Human Homolog		CD46, CD46 molecule, complement regulatory protein
NCBI Gene ID		4179
neXtProt AC		NX_P15529
Human Synonyms		AHUS2, MCP, MIC10, TLX, TRA2.10
Human Chr (Location)		1q32; chr1:207925383-207968861 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD46

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in increased litter sizes sired by mutant males.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	negative regulation of complement activation, proteolysis, ...
Component	acrosomal vesicle, basolateral plasma membrane, ...
Function	complement binding, endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (4)   
Theiler Stages: 17, 28

Assay Type	Results
Northern blot	4
RT-PCR	2

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034956 (Evidence)
Ensembl Gene Model	ENSMUSG00000016493 (Evidence)
Entrez Gene	17221 (Evidence)
UniGene	12884
DFCI	TC1591205, TC1721915
DoTS	DT.55278892, DT.91335126, DT.91588162
NIA Mouse Gene Index	U022231
Consensus CDS Project	CCDS35828.1
International Mouse Knockout Project Status	Cd46

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034956	VEGA Gene Model | MGI Sequence Detail	50964	C57BL/6J
transcript	OTTMUST00000088873	VEGA | MGI Sequence Detail	1828	Not Applicable
polypeptide	OTTMUSP00000048501	VEGA | MGI Sequence Detail	365	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017341	Membrane cofactor protein, CD46
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000001401	membrane cofactor protein

References

(Earliest) J:46287 Tsujimura A, et al., Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells. Biochem J. 1998 Feb 15;330(Pt 1):163-8
(Latest) J:168736 Delano MJ, et al., Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011 Jan 1;186(1):195-202
All references(33)