Phenotypes for Cd46 MGI:5586971 MGI Mouse

abnormal retina morphology ( J:213630 , J:234294 )

• the retina and choroid show an increase in staining for the membrane attack complex of complement, with increased deposition on the inner surface of the retina and the basal surface of RPE cells (J:213630)

• 73% of mice exhibit excessive number of cells in the subretinal space (J:234294)

abnormal retina photoreceptor morphology ( J:234294 )

• shortening of the inner portion of the photoreceptor is seen close to apoptotic bodies in ONL

retina photoreceptor degeneration ( J:234294 )

• 12 month old mice exhibit a reduction of total rhodopsin, indicating a reduction in photoreceptors

abnormal retina pigment epithelium morphology ( J:234294 )

• 60% of mice accumulate lipofuscin granules in the retinal pigment epithelium (RPE) with age

• the size of the RPE layer from apical to basal surface is increased in 58% of 12 month old mice

• increase in the number of vacuoles in the RPE cytoplasm

• vesicles and autophagosomes containing cellular organelles are seen in RPE cells

• increase in membrane attack complex deposition on the RPE-choroid of both males and females, indicating dysregulated complement activation in the eye

abnormal retina outer nuclear layer morphology ( J:234294 )

• the outer nuclear layer (ONL) shows a few apoptotic bodies at 2 months of age with a larger increase at 12 months of age

• the density of nuclei in the ONL is reduced in 12, but not 2, month old mice indicating loss of nuclei

increased susceptibility to age-related retinal degeneration ( J:234294 )

• age-related degenerative changes in the retina and retinal pigment epithelium

abnormal optic choroid morphology ( J:234294 )

• 12 month old mice exhibit zones of hypercellularity in the choroid

abnormal choriocapillaris morphology ( J:234294 )

• lumen of choroidal capillaries is reduced

• some choroidal endothelial cells have no lumen or cytoplasmic fenestrae at 12 months

• 80% of mice exhibit diminution of the chriocapillaris by 12 months of age

increased susceptibility to induced choroid neovascularization ( J:213630 )

• mice are more susceptible to laser-induced choroidal neovascularization than wild-type

abnormal Bruch membrane morphology ( J:234294 )

• Bruchs membrane is irregular with local deposition of electron dense material in 12 month old mice

• increase in thickness of Bruchs membrane in 12 month old mice