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Pole
Gene Detail
 Symbol
Name
ID
Pole
polymerase (DNA directed), epsilon
MGI:1196391
Synonyms pol-epsilon
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.45 cM, cytoband E3-E5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:110286306-110337474 bp, + strand
From VEGA annotation of GRCm38

  51169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA-directed DNA polymerase II
Gene Tree: Pole

Human
homologs
Human Homolog POLE, polymerase (DNA directed), epsilon, catalytic subunit
NCBI Gene ID 5426
neXtProt AC  NX_Q07864
Human Synonyms  CRCS12, FILS, POLE1
Human Chr (Location)  12q24.3; chr12:132623762-132687524 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human POLE
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit increased incidence of tumors and premature death. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
 
Interactions
Pole interacts with 111 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process base-excision repair, gap-filling, cellular response to DNA damage stimulus, ...
Component cytoplasm, epsilon DNA polymerase complex, ...
Function 4 iron, 4 sulfur cluster binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(169)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(174) Genomic(2) cDNA(171) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026219 (Evidence)
Ensembl Gene ModelENSMUSG00000007080 (Evidence)
Entrez Gene18973 (Evidence)
UniGene35061
DFCITC1574920, TC1591827
DoTSDT.101184488, DT.101359998, DT.101379355, DT.488031, DT.97341089
NIA Mouse Gene IndexU005973
EC2.7.7.7
Consensus CDS ProjectCCDS19525.1
International Mouse Knockout Project StatusPole
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026219 VEGA Gene Model | MGI Sequence Detail 51169 C57BL/6J ±  kb
transcript OTTMUST00000064842 VEGA | MGI Sequence Detail 7163 Not Applicable 
polypeptide OTTMUSP00000032240 VEGA | MGI Sequence Detail 2283 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(10)
Polymorphisms PCR(1) : SNPs within 2kb(352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006172 DNA-directed DNA polymerase, family B
InterPro IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
InterPro IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
InterPro IPR013697 DNA polymerase epsilon, catalytic subunit A, C-terminal
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000012969 DNA polymerase epsilon catalytic subunit A
References (Earliest) J:44457 Kamel D, et al., Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice. Biol Reprod. 1997 Dec;57(6):1367-74
(Latest) J:153684 Albertson TM, et al., DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17101-4
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory