Pole Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pole
polymerase (DNA directed), epsilon
MGI:1196391

12 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pole^{Tg(Tyr)2300A-1b1b1Ove}/Pole^{Tg(Tyr)2300A-1b1b1Ove} FVB/N-Pole^{Tg(Tyr)2300A-1b1b1Ove}	embryonic lethality between implantation and placentation, complete penetrance	J:175597
Pole^tm1.1Bdp/Pole^tm1.1Bdp B6.129-Pole^tm1.1Bdp	enlarged spleen	J:153684
	increased adenoma incidence	J:153684
	increased colon adenocarcinoma incidence	J:153684
	increased histiocytic sarcoma incidence	J:153684
	increased intestinal adenocarcinoma incidence	J:153684
	increased intestinal adenoma incidence	J:153684
	increased lung tumor incidence	J:153684
	increased lymphoma incidence	J:153684
	increased small intestine adenocarcinoma incidence	J:153684
	premature death	J:153684
Pole^tm1.1Bdp/Pole^tm1.1Bdp involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	increased tumor incidence	J:153684
	premature death	J:153684

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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