|
Symbol Name ID |
Pole
polymerase (DNA directed), epsilon MGI:1196391 |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukemia |
Lymphoma |
Non-Hodgkin lymphoma |
T-cell lymphoma |
Adenocarcinoma of the colon |
Hereditary nonpolyposis colorectal carcinoma |
Adenomatous colonic polyposis |
Neoplasm of the stomach |
Adenocarcinoma of the small intestine |
Endometrial carcinoma |
Uterine leiomyosarcoma |
Renal cell carcinoma |
Transitional cell carcinoma of the bladder |
Basal cell carcinoma |
Plexiform neurofibroma |
Rhabdomyosarcoma |
Astrocytoma |
Pleomorphic xanthoastrocytoma |
Ependymoma |
Glioblastoma multiforme |
Oligodendroglioma |
Medulloblastoma |
Neuroblastoma |
Alveolar cell carcinoma |
Non-small cell lung carcinoma |
Lung adenocarcinoma |
| Disease(s) Associated with POLE | ||||||||||||||||||||||||||
| colorectal cancer | ||||||||||||||||||||||||||
| endometrial cancer | ||||||||||||||||||||||||||
| lung cancer | ||||||||||||||||||||||||||
| mismatch repair cancer syndrome |
| Mouse Phenotypes | increased intestinal adenocarcinoma incidence |
increased colon adenocarcinoma incidence |
increased small intestine adenocarcinoma incidence |
increased intestinal adenoma incidence |
increased adenoma incidence |
increased lymphoma incidence |
increased histiocytic sarcoma incidence |
increased lung tumor incidence |
increased tumor incidence |
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| Availability | Mouse Genotype | |||||||||
| Poletm1.1Bdp/Poletm1.1Bdp | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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