About   Help   FAQ
Polg
Gene Detail
Symbol

Name
ID
Polg
polymerase (DNA directed), gamma
MGI:1196389
Synonyms
mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma, Polga, Pol gamma, polymerase gamma
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.04 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79448791-79466362 bp, - strand
From VEGA annotation of GRCm38

  17572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POLG
Protein SuperFamily: DNA-directed DNA polymerase, mitochondrial type
Gene Tree: Polg

Human
homologs
POLG, polymerase (DNA directed), gamma
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5428
neXtProt AC: NX_P54098

Human Synonyms: MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE

Human Chr (Location): 15q25; chr15:89316305-89334795 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human POLG

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous proof-reading deficient mutants display reduced life spans and premature aging with weight loss, decreased subcutaneous fat, alopecia, kyphosis, osteoporosis, anemia, reduced fertility, and enlarged hearts. Homozygous null mice display embryonic lethality.
 
Human Diseases Modeled in Mice Using Polg (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Polg interacts with 288 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process aging, DNA biosynthetic process, ...
Component extracellular exosome, gamma DNA polymerase complex, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488393 ; ZFIN polg    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000029097 (Evidence)
Ensembl Gene Model ENSMUSG00000039176 (Evidence)
Entrez Gene 18975 (Evidence)
EC 2.7.7.7
Consensus CDS Project CCDS21382.1
International Mouse Phenotyping Consortium Status Polg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029097 VEGA Gene Model | MGI Sequence Detail 17572 C57BL/6J ±  kb
transcript OTTMUST00000072160 VEGA | MGI Sequence Detail 5277 Not Applicable 
polypeptide OTTMUSP00000037076 VEGA | MGI Sequence Detail 1217 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(15) UniProt(8)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019760 DNA-directed DNA polymerase, family A, conserved site
InterPro IPR002297 DNA-directed DNA-polymerase, family A, mitochondria
InterPro IPR001098 DNA-directed DNA polymerase, family A, palm domain
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000012973 DNA polymerase subunit gamma-1
References
(Earliest) J:45383 Zullo SJ, et al., Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-- >q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs). Cytogenet Cell Genet. 1997;78(3-4):281-4
(Latest) J:220772 Li-Harms X, et al., Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 2015 Jan 1;125(1):162-74
All references(81)
Disease annotation references (2)
Other
accession IDs
MGI:2141822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory