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Polg
Gene Detail
Symbol

Name
ID
Polg
polymerase (DNA directed), gamma
MGI:1196389
Synonyms
mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma, Polga, Pol gamma, polymerase gamma
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.04 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79448791-79466362 bp, - strand
From VEGA annotation of GRCm38

  17572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA-directed DNA polymerase, mitochondrial type
Gene Tree: Polg

Human
homologs
Human Homolog POLG, polymerase (DNA directed), gamma
NCBI Gene ID 5428
neXtProt AC  NX_P54098
Human Synonyms  MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE
Human Chr (Location)  15q25; chr15:89316305-89334795 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human POLG
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous proof-reading deficient mutants display reduced life spans and premature aging with weight loss, decreased subcutaneous fat, alopecia, kyphosis, osteoporosis, anemia, reduced fertility, and enlarged hearts. Homozygous null mice display embryonic lethality.
 
Phenotype Images(4)
Interactions
Polg interacts with 289 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process aging, DNA biosynthetic process, ...
Component extracellular vesicular exosome, gamma DNA polymerase complex, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000029097 (Evidence)
Ensembl Gene ModelENSMUSG00000039176 (Evidence)
Entrez Gene18975 (Evidence)
EC2.7.7.7
Consensus CDS ProjectCCDS21382.1
International Mouse Knockout Project StatusPolg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029097 VEGA Gene Model | MGI Sequence Detail 17572 C57BL/6J ±  kb
transcript OTTMUST00000072160 VEGA | MGI Sequence Detail 5277 Not Applicable 
polypeptide OTTMUSP00000037076 VEGA | MGI Sequence Detail 1217 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(13) UniProt(8)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019760 DNA-directed DNA polymerase, family A, conserved site
InterPro IPR002297 DNA-directed DNA-polymerase, family A, mitochondria
InterPro IPR016265 DNA-directed DNA polymerase, family A, mitochondria, subgroup
InterPro IPR001098 DNA-directed DNA polymerase, family A, palm domain
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000012973 DNA polymerase subunit gamma-1
References
(Earliest) J:45383 Zullo SJ, et al., Localization by fluorescence in situ hybridization (FISH) of human mitochondrial polymerase gamma (POLG) to human chromosome band 15q24-- >q26, and of mouse mitochondrial polymerase gamma (Polg) to mouse chromosome band 7E, with confirmation by direct sequence analysis of bacterial artificial chromosomes (BACs). Cytogenet Cell Genet. 1997;78(3-4):281-4
(Latest) J:205430 Ross JM, et al., Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature. 2013 Sep 19;501(7467):412-5
All references(75)
Other
accession IDs
MGI:2141822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory