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Mre11a Gene Detail
Summary
  • Symbol
    Mre11a
  • Name
    MRE11A homolog A, double strand break repair nuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100512
    NCBI Gene: 17535
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14695971-14748421 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1489 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100512
 protein coding gene Chr9:14695950-14748421 (+)
129S1/SvImJ ENSMUSG00200044209
 protein coding gene Chr9:11598559-11650246 (+)
A/J ENSMUSG00195031756
 protein coding gene Chr9:11484126-11535825 (+)
AKR/J ENSMUSG00220027653
 protein coding gene Chr9:11461567-11513265 (+)
BALB/cJ ENSMUSG00180036408
 protein coding gene Chr9:11608019-11659721 (+)
C3H/HeJ ENSMUSG00175033678
 protein coding gene Chr9:11555055-11606749 (+)
C57BL/6NJ ENSMUSG00215028707
 protein coding gene Chr9:11549644-11601341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031788
 protein coding gene Chr9:10990943-11043169 (+)
CAST/EiJ ENSTCUG00005026780
 protein coding gene Chr9:11583867-11635459 (+)
CBA/J ENSMUSG00210035874
 protein coding gene Chr9:11586011-11637708 (+)
DBA/2J ENSMUSG00185022520
 protein coding gene Chr9:11674730-11726419 (+)
FVB/NJ ENSMUSG00205027530
 protein coding gene Chr9:11658726-11710434 (+)
JF1/MsJ ENSUMUG00000042535
 protein coding gene Chr9:11657494-11708824 (+)
LP/J ENSMUSG00230038693
 protein coding gene Chr9:12096660-12148345 (+)
NOD/ShiLtJ ENSMUSG00190026693
 protein coding gene Chr9:11585251-11636939 (+)
NZO/HlLtJ ENSMUSG00225049855
 protein coding gene Chr9:11985456-12037156 (+)
PWK/PhJ ENSLUMG00010041140
 protein coding gene Chr9:11595745-11644621 (+)
SPRET/EiJ ENSMSPG00010021073
 protein coding gene Chr9:11778163-11829130 (+)
WSB/EiJ ENSIUOG00005043711
 protein coding gene Chr9:11253608-11305420 (+)



Homology
more
  • Human Ortholog
    MRE11, MRE11 double strand break repair nuclease
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRE11, MRE11 double strand break repair nuclease
  • Synonyms
    ATLD, HNGS1, MRE11A, MRE11B
  • Links
    NCBI Gene ID: 4361
    UniProt: P49959

  • Chr Location
    11q21; chr11:94415570-94512412 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human MRE11 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    7
  • cDNA Data
    84
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17535 NCBI Gene Model | MGI Sequence Detail 52451 C57BL/6J ±  kb
    transcript NM_001411899 RefSeq | MGI Sequence Detail 5829 C57BL/6  
    polypeptide Q61216 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000010562 double-strand break repair protein MRE11
      (term hierarchy)
    • EC
      3.1.-.-
    • InterPro Domains
      IPR004843 Calcineurin-like, phosphoesterase domain
      IPR003701 DNA double-strand break repair protein Mre11
      IPR041796 DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain
      IPR029052 Metallo-dependent phosphatase-like
      IPR038487 Mre11, capping domain
      IPR007281 Mre11, DNA-binding
    • GlyGen
      Q61216 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 6
      cDNA 84
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 9
      Gene Ontology 26
      Phenotypes 33
    • Earliest
      J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
    • Latest
      J:378362 Ruan T, et al., A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice. Nucleic Acids Res. 2026 Jan 22;54(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory