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Mre11a
Gene Detail
Symbol

Name
ID
Mre11a
meiotic recombination 11 homolog A (S. cerevisiae)
MGI:1100512
Feature Type
protein coding gene
Genetic Map
Chromosome 9
4.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:14784654-14837123 bp, + strand
From VEGA annotation of GRCm38

  52470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: double-strand break repair protein MRE11
Gene Tree: Mre11a

Human
homologs
Human Homolog MRE11A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NCBI Gene ID 4361
neXtProt AC  NX_P49959
Human Synonyms  ATLD, HNGS1, MRE11, MRE11B
Human Chr (Location)  11q21; chr11:94417300-94493874 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MRE11A
Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(27) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.
 
Interactions
Mre11a interacts with 319 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process base-excision repair, cell proliferation, ...
Component chromatin, chromosome, telomeric region, ...
Function 3'-5' exonuclease activity, ATP-dependent DNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(83)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(89) Genomic(6) cDNA(83)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031684 (Evidence)
Ensembl Gene ModelENSMUSG00000031928 (Evidence)
Entrez Gene17535 (Evidence)
UniGene149071
DFCITC1594250, TC1643858, TC1576483
DoTSDT.97351375, DT.490433
NIA Mouse Gene IndexU042950
Consensus CDS ProjectCCDS22827.1
International Mouse Knockout Project StatusMre11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031684 VEGA Gene Model | MGI Sequence Detail 52470 C57BL/6J ±  kb
transcript OTTMUST00000078494 VEGA | MGI Sequence Detail 3286 Not Applicable 
polypeptide OTTMUSP00000041737 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(17) UniProt(15)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003701 DNA repair protein Mre11
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR007281 Mre11, DNA-binding
Protein Ontology PR:000010562 double-strand break repair protein MRE11A
References
(Earliest) J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
(Latest) J:212924 Katyal S, et al., Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
All references(60)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory