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Mre11a Gene Detail
Summary
  • Symbol
    Mre11a
  • Name
    meiotic recombination 11 homolog A (S. cerevisiae)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100512
    NCBI Gene: 17535
Location & Maps
more
  • Sequence Map
    Chr9:14784654-14837123 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52470 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MRE11A, MRE11 homolog A, double strand break repair nuclease
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRE11A, MRE11 homolog A, double strand break repair nuclease
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATLD, HNGS1, MRE11, MRE11B
  • Links
    NCBI Gene ID: 4361
    neXtProt AC: NX_P49959

  • Chr Location
    11q21; chr11:94415578-94512185 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MRE11A associations

Human Disease Mouse Models
       Ataxia-Telangiectasia-Like Disorder 1; ATLD1   OMIM: 604391
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Gene trapped
    27
  • Targeted
    6
  • Incidental Mutations
Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031684 VEGA Gene Model | MGI Sequence Detail 52470 C57BL/6J ±  kb
transcript OTTMUST00000078494 VEGA | MGI Sequence Detail 3286 Not Applicable  
polypeptide OTTMUSP00000041737 VEGA | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    165 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000010562 double-strand break repair protein MRE11A
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR003701 DNA double-strand break repair protein Mre11
    IPR029052 Metallo-dependent phosphatase-like
    IPR007281 Mre11, DNA-binding
Molecular
Reagents
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  • All nucleic 89
    Genomic 6
    cDNA 83

    Microarray probesets 4
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 20
  • Earliest
    J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
  • Latest
    J:224234 Pacheco S, et al., The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet. 2015 Mar;11(3):e1005017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory