Mre11a
Gene Detail

Symbol Name ID

Mre11a meiotic recombination 11 homolog A (S. cerevisiae) MGI:1100512

Feature Type

protein coding gene

Genetic Map

Chromosome 9

4.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:14784654-14837123 bp, + strand From VEGA annotation of GRCm38   52470 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: double-strand break repair protein MRE11
Gene Tree: Mre11a

Human homologs

Human Homolog		MRE11A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NCBI Gene ID		4361
neXtProt AC		NX_P49959
Human Synonyms		ATLD, HNGS1, MRE11, MRE11B
Human Chr (Location)		11q21; chr11:94150466-94227040 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MRE11A

Alleles and phenotypes

All alleles(33) : Targeted(6) Gene trapped(27)
 

Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	cell proliferation, chromosome organization, ...
Component	chromosome, telomeric region, condensed nuclear chromosome, ...
Function	ATP-dependent DNA helicase activity, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
cDNA source data(83)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(6) cDNA(83)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031684 (Evidence)
Ensembl Gene Model	ENSMUSG00000031928 (Evidence)
Entrez Gene	17535 (Evidence)
UniGene	149071
DFCI	TC1576483, TC1594250, TC1643858
DoTS	DT.490433, DT.97351375
NIA Mouse Gene Index	U042950
Consensus CDS Project	CCDS22827.1
International Mouse Knockout Project Status	Mre11a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031684	VEGA Gene Model | MGI Sequence Detail	52470	C57BL/6J
transcript	OTTMUST00000078494	VEGA | MGI Sequence Detail	3286	Not Applicable
polypeptide	OTTMUSP00000041737	VEGA | MGI Sequence Detail	706	Not Applicable

All sequences(52) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003701	DNA repair protein Mre11
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR007281	Mre11, DNA-binding
Protein Ontology	PR:000010562	double-strand break repair protein MRE11A

References

(Earliest) J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(56)