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Mre11a
Gene Detail
Symbol

Name
ID
Mre11a
meiotic recombination 11 homolog A (S. cerevisiae)
MGI:1100512
Feature Type
protein coding gene
Genetic Map
Chromosome 9
4.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:14784654-14837123 bp, + strand
From VEGA annotation of GRCm38

  52470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MRE11A
Protein SuperFamily: double-strand break repair protein MRE11
Gene Tree: Mre11a

Human
homologs
MRE11A, MRE11 homolog, double strand break repair nuclease A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4361
neXtProt AC: NX_P49959

Human Synonyms: ATLD, HNGS1, MRE11, MRE11B

Human Chr (Location): 11q21; chr11:94415578-94512185 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MRE11A

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(27) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.
 
Interactions
Mre11a interacts with 318 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process base-excision repair, cell proliferation, ...
Component chromatin, chromosome, telomeric region, ...
Function 3'-5' exonuclease activity, ATP-dependent DNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(83)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MRE11A ; Xenbase mre11a ; ZFIN mre11a    NEW 
Molecular
reagents
All nucleic(89) Genomic(6) cDNA(83)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031684 (Evidence)
Ensembl Gene Model ENSMUSG00000031928 (Evidence)
Entrez Gene 17535 (Evidence)
UniGene 149071
DFCI TC1643858, TC1576483, TC1594250
DoTS DT.97351375, DT.490433
NIA Mouse Gene Index U042950
Consensus CDS Project CCDS22827.1
International Mouse Phenotyping Consortium Status Mre11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031684 VEGA Gene Model | MGI Sequence Detail 52470 C57BL/6J ±  kb
transcript OTTMUST00000078494 VEGA | MGI Sequence Detail 3286 Not Applicable 
polypeptide OTTMUSP00000041737 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(17) UniProt(8)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003701 DNA repair protein Mre11
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR007281 Mre11, DNA-binding
Protein Ontology PR:000010562 double-strand break repair protein MRE11A
References
(Earliest) J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
(Latest) J:212924 Katyal S, et al., Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory