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Mre11a Gene Detail
Summary
  • Symbol
    Mre11a
  • Name
    MRE11A homolog A, double strand break repair nuclease
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100512
    NCBI Gene: 17535
  • Gene Overview
    MyGene.info: MRE11
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14784654-14837123 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 4.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100512
protein coding gene Chr9:14784654-14837125 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034356
protein coding gene Chr9:11738339-11797481 (+)
A/J MGP_AJ_G0034334
protein coding gene Chr9:11684105-11739697 (+)
AKR/J MGP_AKRJ_G0034262
protein coding gene Chr9:11696459-11750092 (+)
BALB/cJ MGP_BALBcJ_G0034328
protein coding gene Chr9:11457557-11513004 (+)
C3H/HeJ MGP_C3HHeJ_G0034039
protein coding gene Chr9:11992512-12048694 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034850
protein coding gene Chr9:12123666-12182284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031788
protein coding gene Chr9:10990943-11043169 (+)
CAST/EiJ MGP_CASTEiJ_G0033366
protein coding gene Chr9:11835610-11894371 (+)
CBA/J MGP_CBAJ_G0034012
protein coding gene Chr9:12691672-12747757 (+)
DBA/2J MGP_DBA2J_G0034169
protein coding gene Chr9:11562006-11617085 (+)
FVB/NJ MGP_FVBNJ_G0034114
protein coding gene Chr9:11154860-11209680 (+)
LP/J MGP_LPJ_G0034255
protein coding gene Chr9:11839969-11891877 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034158
protein coding gene Chr9:13733082-13787200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034869
protein coding gene Chr9:11702933-11765816 (+)
PWK/PhJ MGP_PWKPhJ_G0033072
protein coding gene Chr9:11632102-11685290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032908
protein coding gene Chr9:11808611-11862204 (+)
WSB/EiJ MGP_WSBEiJ_G0033482
protein coding gene Chr9:11561706-11618425 (+)



Homology
more
  • Human Ortholog
    MRE11, MRE11 homolog, double strand break repair nuclease
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRE11, MRE11 homolog, double strand break repair nuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATLD, HNGS1, MRE11A, MRE11B
  • Links
    NCBI Gene ID: 4361
    neXtProt AC: NX_P49959
    UniProt: P49959

  • Chr Location
    11q21; chr11:94415570-94512701 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Though mutation of this locus affected chromosome stability, mutant mice were no more susceptible to tumorigenesis than wild-type mice. Mutant female mice showed reduced fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031928 Ensembl Gene Model | MGI Sequence Detail 52470 C57BL/6J ±  kb
transcript ENSMUST00000034405 Ensembl | MGI Sequence Detail 3286 Not Applicable  
polypeptide ENSMUSP00000034405 Ensembl | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 90
    Genomic 6
    cDNA 84

    Microarray probesets 4
References
more
  • Summaries
    All 68
    Developmental Gene Expression 4
    Gene Ontology 17
    Phenotypes 22
  • Earliest
    J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
  • Latest
    J:258212 Morales AJ, et al., A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife. 2017 Mar 31;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory