Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable identical protein binding activity and nuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; breast carcinoma; endometrial cancer; and gastrointestinal system cancer (multiple). Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).