Symbol
Name
ID

Mre11a
MRE11A homolog A, double strand break repair nuclease
MGI:1100512

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased sensitivity to ionizing radiation
Disease(s) Associated with MRE11	Increased sensitivity to ionizing radiation
ataxia-telangiectasia-like disorder-1

Mouse Phenotypes

cellular phenotype

abnormal cell cycle checkpoint function

increased mitotic index

decreased cellular sensitivity to ionizing radiation

increased cellular sensitivity to ionizing radiation

decreased cell proliferation

abnormal DNA repair

chromosomal instability

chromosome breakage

induced chromosome breakage

spontaneous chromosome breakage

maternal effect

Availability

Mouse Genotype

Mre11a^tm1.1Rchd/Mre11a^tm1.1Rchd

Mre11a^tm1Jpt/Mre11a^tm1Jpt

Mre11a^tm1Dof/Mre11a^tm2.1Dof (conditional)

Mre11a^tm2.1Dof/Mre11a^tm2.2Dof (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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