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Tnfsf11
Gene Detail
 Symbol
Name
ID
Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089
Synonyms Ly109l, ODF, OPGL, OPGL, osteoclast differentiation factor, RANKL, Trance
Feature Type protein coding gene
Genetic Map
Chromosome 14
41.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:78277446-78308043 bp, - strand
From NCBI annotation of GRCm38

  30598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor ligand superfamily member, 10/11 types
Gene Tree: Tnfsf11

Human
homologs
Human Homolog TNFSF11, tumor necrosis factor (ligand) superfamily, member 11
NCBI Gene ID 8600
neXtProt AC  NX_O14788
Human Synonyms  CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TRANCE
Human Chr (Location)  13q14; chr13:42562736-42608013 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TNFSF11
Alleles
and
phenotypes
All alleles(14) : Targeted(10) Gene trapped(3) Chemically induced(1)
 
Mice homozygous for a null allele exhibit a failure of tooth eruption, osteopetrosis, failure to lactate and arrested alveolar bud differentiation during pregnancy.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process activation of JUN kinase activity, bone resorption, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (30)    Tissues (17)    Images (2)
Theiler Stages: 23, 26
Assay TypeResults
RNA in situ 24
Northern blot 6
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022015 (Evidence)
Entrez Gene21943 (Evidence)
UniGene249221
DFCITC1585585
DoTSDT.101354232, DT.55175956, DT.91371637, DT.91444147
NIA Mouse Gene IndexU035798
PDB1IQA, 1JTZ, 3QBQ, 4E4D, 4GIQ, 1S55, 3ME2
Consensus CDS ProjectCCDS27294.1
International Mouse Knockout Project StatusTnfsf11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21943 NCBI Gene Model | MGI Sequence Detail 30598 C57BL/6J ±  kb
transcript NM_011613 RefSeq | MGI Sequence Detail 2243 C57BL/6 
polypeptide O35235 UniProt | EBI | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR017355 Tumour necrosis factor ligand 10/11
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002107 tumor necrosis factor ligand superfamily member 11
Graphical View of Protein Domain Structure
References (Earliest) J:43257 Wong BR, et al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem. 1997 Oct 3;272(40):25190-4
(Latest) J:206133 Jenkinson SR, et al., TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12
All references(170)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory