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Tnfsf11 Gene Detail
Summary
  • Symbol
    Tnfsf11
  • Name
    tumor necrosis factor (ligand) superfamily, member 11
  • Synonyms
    Ly109l, ODF, OPGL, OPGL, osteoclast differentiation factor, RANKL, Trance
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100089
    NCBI Gene: 21943
  • Gene Overview
    MyGene.info: TNFSF11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:78277446-78308043 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30598 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.26 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TNFSF11, TNF superfamily member 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFSF11, TNF superfamily member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TNLG6B, TRANCE
  • Links
    NCBI Gene ID: 8600
    neXtProt AC: NX_O14788
    UniProt: O14788

  • Chr Location
    13q14.11; chr13:42562736-42608013 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tnfsf11 mouse models; 1 with human TNFSF11 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 7 alleles in 13 genetic backgrounds
    30 phenotypes from multigenic genotypes
    4 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a failure of tooth eruption, osteopetrosis, failure to lactate and arrested alveolar bud differentiation during pregnancy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21943 NCBI Gene Model | MGI Sequence Detail 30598 C57BL/6J ±  kb
    transcript NM_011613 RefSeq | MGI Sequence Detail 2243 C57BL/6  
    polypeptide O35235 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      215 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 310
      Developmental Gene Expression 40
      Diseases 4
      Gene Ontology 35
      Phenotypes 57
    • Earliest
      J:43257 Wong BR, et al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem. 1997 Oct 3;272(40):25190-4
    • Latest
      J:257962 Tsukasaki M, et al., Host defense against oral microbiota by bone-damaging T cells. Nat Commun. 2018 Feb 16;9(1):701

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory