Tnfsf11
Gene Detail

Symbol Name ID

Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 MGI:1100089

Synonyms

Ly109l, ODF, OPGL, OPGL, osteoclast differentiation factor, RANKL, Trance

Feature Type

protein coding gene

Genetic Map

Chromosome 14

41.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr14:78277446-78308043 bp, - strand From NCBI annotation of GRCm38   30598 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor ligand superfamily member, 10/11 types
Gene Tree: Tnfsf11

Human homologs

Human Homolog		TNFSF11, tumor necrosis factor (ligand) superfamily, member 11
NCBI Gene ID		8600
neXtProt AC		NX_O14788
Human Synonyms		CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TRANCE
Human Chr (Location)		13q14; chr13:43136872-43182149 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TNFSF11

Alleles and phenotypes

All alleles(12) : Targeted(8) Gene trapped(3) Chemically induced(1)
 

Mice homozygous for a null allele exhibit a failure of tooth eruption, osteopetrosis, failure to lactate and arrested alveolar bud differentiation during pregnancy.

 
Phenotype Images(14)

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	activation of JUN kinase activity, bone resorption, ...
Component	cytoplasm, extracellular region, ...
Function	cytokine activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (30)    Tissues (17)    Images (2)
Theiler Stages: 23, 26

Assay Type	Results
RNA in situ	24
Northern blot	6

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(14)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022015 (Evidence)
Entrez Gene	21943 (Evidence)
UniGene	249221
DFCI	TC1585585
DoTS	DT.101354232, DT.55175956, DT.91371637, DT.91444147
NIA Mouse Gene Index	U035798
PDB	1IQA, 1JTZ, 3QBQ, 4E4D, 4GIQ, 1S55, 3ME2
Consensus CDS Project	CCDS27294.1
International Mouse Knockout Project Status	Tnfsf11

Sequences

Length	Strain/Species
genomic	21943	NCBI Gene Model | MGI Sequence Detail	30598	C57BL/6J
transcript	NM_011613	RefSeq | MGI Sequence Detail	2243	C57BL/6
polypeptide	O35235	UniProt | EBI | MGI Sequence Detail	316	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(174 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR017355	Tumour necrosis factor ligand 10/11
InterPro	IPR008983	Tumour necrosis factor-like
Protein Ontology	PR:000002107	tumor necrosis factor ligand superfamily member 11

Graphical View of Protein Domain Structure

References

(Earliest) J:43257 Wong BR, et al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem. 1997 Oct 3;272(40):25190-4
(Latest) J:193769 Robertson Remen KM, et al., Activation of the liver X receptor-beta potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages. J Leukoc Biol. 2013 Jan;93(1):71-82
All references(163)