Nfkb2
Gene Detail

Symbol

Name
ID

Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800

Synonyms

NF kappaB2, p52

Feature Type

protein coding gene

Genetic Map

Chromosome 19
38.80 cM, cytoband C3-D2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:46304737-46312090 bp, + strand From Ensembl annotation of GRCm38   7354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb2

Human
homologs

Human Homolog		NFKB2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NCBI Gene ID		4791
neXtProt AC		NX_Q00653
Human Synonyms		CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p100, p52
Human Chr (Location)		10q24; chr10:102394110-102402529 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human NFKB2

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Chemically induced (ENU)(2) Targeted(7) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.

 
Human Diseases Modeled in Mice Using Nfkb2 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)

Interactions

Nfkb2 interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (37 annotations)

Process	cellular response to stress, extracellular matrix organization, ...
Component	Bcl3/NF-kappaB2 complex, cytoplasm, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (69)    Tissues (44)    Images (13)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	61
RT-PCR	8

cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(27) Genomic(12) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000025225 (Evidence)
Entrez Gene	18034 (Evidence)
DFCI	TC1756167, TC1629655, TC1575937
NIA Mouse Gene Index	U019521
PDB	3JV6, 3JV5
Consensus CDS Project	CCDS29874.1
International Mouse Knockout Project Status	Nfkb2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025225	Ensembl Gene Model | MGI Sequence Detail	7354	C57BL/6J
transcript	ENSMUST00000073116	Ensembl | MGI Sequence Detail	3054	Not Applicable
polypeptide	ENSMUSP00000072859	Ensembl | MGI Sequence Detail	899	Not Applicable

All sequences(55) RefSeq(8) UniProt(8)

Polymorphisms

PCR(1) : SNPs within 2kb(34 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000451	NF-kappa-B/Rel/Dorsal
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR011539	Rel homology domain
Protein Ontology	PR:000011178	nuclear factor NF-kappa-B p100 subunit

References

(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:213803 Zhang H, et al., NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest. 2014 Jul 1;124(7):3200-14
All references(133)
Disease annotation references (1)