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Nfkb2
Gene Detail
Symbol

Name
ID
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800
Synonyms
NF kappaB2, p52
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.80 cM, cytoband C3-D2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:46304737-46312090 bp, + strand
From Ensembl annotation of GRCm38

  7354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFKB2
Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb2

Human
homologs
NFKB2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4791
neXtProt AC: NX_Q00653

Human Synonyms: CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p100, p52

Human Chr (Location): 10q24; chr10:102394110-102402529 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NFKB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(3) Targeted(7) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.
 
Human Diseases Modeled in Mice Using Nfkb2 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Nfkb2 interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process extracellular matrix organization, follicular dendritic cell differentiation, ...
Component Bcl3/NF-kappaB2 complex, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (69)    Tissues (44)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
RT-PCR 8
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfkb2 ; ZFIN nfkb2    NEW 
Molecular
reagents
All nucleic(27) Genomic(12) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025225 (Evidence)
Entrez Gene 18034 (Evidence)
DFCI TC1575937, TC1629655, TC1756167
NIA Mouse Gene Index U019521
PDB 3JV5, 3JV6
Consensus CDS Project CCDS29874.1
International Mouse Phenotyping Consortium Status Nfkb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025225 Ensembl Gene Model | MGI Sequence Detail 7354 C57BL/6J ±  kb
transcript ENSMUST00000073116 Ensembl | MGI Sequence Detail 3054 Not Applicable 
polypeptide ENSMUSP00000072859 Ensembl | MGI Sequence Detail 899 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(8)
Polymorphisms
PCR(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002909 IPT domain
InterPro IPR000451 NF-kappa-B/Dorsal
InterPro IPR030497 Nuclear factor NF-kappa-B, p100 subunit
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR030492 Rel homology domain, conserved site
InterPro IPR011539 Rel homology domain (RHD), DNA-binding domain
Protein Ontology PR:000011178 nuclear factor NF-kappa-B p100 subunit
References
(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:222748 Burkitt MD, et al., NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. J Pathol. 2015 Jul;236(3):326-36
All references(134)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory