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Nfkb2 Gene Detail
Summary
  • Symbol
    Nfkb2
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
  • Synonyms
    NF kappaB2, p52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099800
    NCBI Gene: 18034
  • Gene Overview
    MyGene.info: NFKB2
Location & Maps
more
  • Sequence Map
    Chr19:46304737-46312090 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7354 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.80 cM, cytoband C3-D2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    NFKB2, nuclear factor kappa B subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFKB2, nuclear factor kappa B subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p100, p49/p100, p52
  • Links
    NCBI Gene ID: 4791
    neXtProt AC: NX_Q00653

  • Chr Location
    10q24; chr10:102394110-102402529 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Nfkb2 mouse models; 1 with human NFKB2 associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 1; CVID1   OMIM: 607594 View 3 models
       Immunodeficiency, Common Variable, 10; CVID10   OMIM: 615577
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 7 alleles in 10 genetic backgrounds
    40 phenotypes from multigenic genotypes
    2 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    3
  • Targeted
    8
  • Transgenic
    2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    69
  • Tissues
    44
  • cDNA Data
    12
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025225 Ensembl Gene Model | MGI Sequence Detail 7354 C57BL/6J ±  kb
transcript ENSMUST00000073116 Ensembl | MGI Sequence Detail 3054 Not Applicable  
polypeptide ENSMUSP00000072859 Ensembl | MGI Sequence Detail 899 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 12
    cDNA 12
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 137
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 10
    Phenotypes 70
  • Earliest
    J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
  • Latest
    J:233743 De Silva NS, et al., Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-kappaB Transcription Factors RELB and NF-kappaB2 in B Cells. J Immunol. 2016 Mar 15;196(6):2591-601
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory