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Nfkb2 Gene Detail
Summary
  • Symbol
    Nfkb2
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
  • Synonyms
    NF kappaB2, p52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099800
    NCBI Gene: 18034
  • Gene Overview
    MyGene.info: NFKB2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:46304737-46312090 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7354 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.80 cM, cytoband C3-D2
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    NFKB2, nuclear factor kappa B subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFKB2, nuclear factor kappa B subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p100, p49/p100, p52
  • Links
    NCBI Gene ID: 4791
    neXtProt AC: NX_Q00653
    UniProt: Q00653

  • Chr Location
    10q24.32; chr10:102394110-102402529 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Nfkb2 mouse models; 1 with human NFKB2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    120 phenotypes from 7 alleles in 10 genetic backgrounds
    40 phenotypes from multigenic genotypes
    2 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    76
  • Tissues
    45
  • cDNA Data
    12
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025225 Ensembl Gene Model | MGI Sequence Detail 7354 C57BL/6J ±  kb
    transcript ENSMUST00000073116 Ensembl | MGI Sequence Detail 3054 Not Applicable  
    polypeptide ENSMUSP00000072859 Ensembl | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      35 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 12
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 10
      Phenotypes 76
    • Earliest
      J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
    • Latest
      J:260924 Grinberg-Bleyer Y, et al., The Alternative NF-kappaB Pathway in Regulatory T Cell Homeostasis and Suppressive Function. J Immunol. 2018 Apr 1;200(7):2362-2371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory