Nfkb2 MGI Mouse Gene Detail - MGI:1099800 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Symbol

Nfkb2
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms

NF kappaB2, p52

Feature Type

protein coding gene
IDs

MGI:1099800
NCBI Gene: 18034
Gene Overview

MyGene.info: NFKB2
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr19:46304737-46312090 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.80 cM, cytoband C3-D2
Mapping Data

8 experiments

SNPs within 2kb

35 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099800	protein coding gene	Chr19:46304320-46312090 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0025203	protein coding gene	Chr19:45985843-45993056 (+)
A/J	MGP_AJ_G0025179	protein coding gene	Chr19:43721500-43728833 (+)
AKR/J	MGP_AKRJ_G0025148	protein coding gene	Chr19:45138282-45145723 (+)
BALB/cJ	MGP_BALBcJ_G0025174	protein coding gene	Chr19:43780476-43787738 (+)
C3H/HeJ	MGP_C3HHeJ_G0024934	protein coding gene	Chr19:45306184-45313399 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025617	protein coding gene	Chr19:47134670-47143311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023031	protein coding gene	Chr19:42960176-42967531 (+)
CAST/EiJ	MGP_CASTEiJ_G0024399	protein coding gene	Chr19:45101742-45110723 (+)
CBA/J	MGP_CBAJ_G0024914	protein coding gene	Chr19:49492531-49499743 (+)
DBA/2J	MGP_DBA2J_G0025046	protein coding gene	Chr19:43544859-43552226 (+)
FVB/NJ	MGP_FVBNJ_G0025007	protein coding gene	Chr19:43322007-43329243 (+)
LP/J	MGP_LPJ_G0025132	protein coding gene	Chr19:45895396-45903766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025038	protein coding gene	Chr19:48835069-48842156 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025675	protein coding gene	Chr19:45246268-45253480 (+)
PWK/PhJ	MGP_PWKPhJ_G0024148	protein coding gene	Chr19:43490797-43498601 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023952	protein coding gene	Chr19:43898826-43906196 (+)
WSB/EiJ	MGP_WSBEiJ_G0024469	protein coding gene	Chr19:45386634-45395101 (+)

Human Ortholog

NFKB2, nuclear factor kappa B subunit 2

Vertebrate Orthologs

10

Human Ortholog

NFKB2, nuclear factor kappa B subunit 2
Orthology source: HomoloGene, HGNC
Synonyms

CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p100, p49/p100, p52
Links

HGNC:7795

NCBI Gene ID: 4791

neXtProt AC: NX_Q00653

UniProt: Q00653
Chr Location

10q24.32; chr10:102394110-102402529 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1873
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFKB2
Protein SuperFamily

transcription factor NF-kappa-B2
Gene Tree

Nfkb2

Diseases

1 with Nfkb2 mouse models; 1 with human NFKB2 associations

Human Disease

Mouse Models

common variable immunodeficiency

IDs

View 3 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

120 phenotypes from 7 alleles in 10 genetic backgrounds
40 phenotypes from multigenic genotypes
2 images
79 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

3
Targeted

8
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.

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All GO Annotations

23
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

76
Tissues

45
cDNA Data

13
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfkb2

ZFIN nfkb2

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Nfkb2 interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

71
RefSeq

8
UniProt

8
CCDS

CCDS29874.1

Ensembl

ENSMUSG00000025225 (Evidence)
NCBI Gene

18034

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025225	Ensembl Gene Model \| MGI Sequence Detail	7354	C57BL/6J	± kb
transcript	ENSMUST00000073116	Ensembl \| MGI Sequence Detail	3054	Not Applicable
polypeptide	ENSMUSP00000072859	Ensembl \| MGI Sequence Detail	899	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011178 nuclear factor NF-kappa-B p100 subunit

(term hierarchy)
PDB

3JV5, 3JV6
InterPro Domains

IPR002110 Ankyrin repeat

IPR020683 Ankyrin repeat-containing domain

IPR036770 Ankyrin repeat-containing domain superfamily

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR000451 NF-kappa-B/Dorsal

IPR033926 NFkappaB IPT domain

IPR008967 p53-like transcription factor, DNA-binding

IPR032397 Rel homology dimerisation domain

IPR030492 Rel homology domain, conserved site

IPR011539 Rel homology domain (RHD), DNA-binding domain

IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily

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All nucleic 28

Genomic 12

cDNA 13

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 168

Developmental Gene Expression 14

Diseases 1

Gene Ontology 9

Phenotypes 79
Earliest

J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
Latest

J:266317 Parvatiyar K, et al., A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. Nat Commun. 2018 Jul 17;9(1):2770

TSS for Nfkb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156722	Chr19:46304390-46304406 (+)	-339 bp
Tssr156723	Chr19:46304709-46304811 (+)	23 bp
Tssr156724	Chr19:46304830-46304839 (+)	98 bp
Tssr156725	Chr19:46305682-46305741 (+)	975 bp
Tssr156726	Chr19:46305745-46305787 (+)	1,029 bp
Tssr156727	Chr19:46305856-46305870 (+)	1,126 bp
Tssr156728	Chr19:46305884-46305907 (+)	1,159 bp
Tssr156729	Chr19:46305909-46305927 (+)	1,181 bp
Tssr156730	Chr19:46305943-46305961 (+)	1,215 bp
Tssr156731	Chr19:46305972-46305981 (+)	1,240 bp
Tssr156732	Chr19:46306023-46306032 (+)	1,291 bp
Tssr156733	Chr19:46306093-46306109 (+)	1,364 bp
Tssr156734	Chr19:46306117-46306154 (+)	1,399 bp
Tssr156735	Chr19:46306160-46306171 (+)	1,429 bp
Tssr156736	Chr19:46306243-46306255 (+)	1,512 bp
Tssr156737	Chr19:46306258-46306263 (+)	1,524 bp
Tssr156738	Chr19:46307351-46307373 (+)	2,625 bp
Tssr156741	Chr19:46310205-46310230 (+)	5,481 bp
Tssr156742	Chr19:46310302-46310317 (+)	5,573 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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