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Nfkb2
Gene Detail
 Symbol
Name
ID
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
MGI:1099800
Synonyms NF kappaB2, p52
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.80 cM, cytoband C3-D2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:46304737-46312090 bp, + strand
From NCBI annotation of GRCm38

  7354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb2

Human
homologs
Human Homolog NFKB2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NCBI Gene ID 4791
neXtProt AC  NX_Q00653
Human Synonyms  CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p105, p52
Human Chr (Location)  10q24; chr10:102394110-102402529 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NFKB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.
 
Human Diseases Modeled Using Mouse Nfkb2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Nfkb2 interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process extracellular matrix organization, follicular dendritic cell differentiation, ...
Component Bcl3/NF-kappaB2 complex, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (69)    Tissues (44)    Images (13)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 61
RT-PCR 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(12) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025225 (Evidence)
Entrez Gene18034 (Evidence)
DFCITC1575937, TC1629655, TC1756167
NIA Mouse Gene IndexU019521
PDB3JV5, 3JV6
Consensus CDS ProjectCCDS29874.1
International Mouse Knockout Project StatusNfkb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18034 NCBI Gene Model | MGI Sequence Detail 7354 C57BL/6J ±  kb
transcript NM_019408 RefSeq | MGI Sequence Detail 3205 C57BL/6 
polypeptide Q9WTK5 UniProt | EBI | MGI Sequence Detail 899 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(8)
Polymorphisms PCR(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011178 nuclear factor NF-kappa-B p100 subunit
Graphical View of Protein Domain Structure
References (Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:209992 Jin J, et al., Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014 Mar 20;40(3):342-54
All references(130)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory