Nfkb2
Gene Detail

Symbol Name ID

Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 MGI:1099800

Synonyms

NF kappaB2, p52

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.80 cM, cytoband C3-D2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:46304737-46312090 bp, + strand From NCBI annotation of GRCm38   7354 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb2

Human homologs

Human Homolog		NFKB2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NCBI Gene ID		4791
neXtProt AC		NX_Q00653
Human Synonyms		CVID10, H2TF1, LYT10, LYT-10, NF-kB2, p105, p52
Human Chr (Location)		10q24; chr10:102394110-102402529 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human NFKB2

Mutations, alleles, and phenotypes

All mutations/alleles(9) : Chemically induced (ENU)(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality.

 
Human Diseases Modeled Using Mouse Nfkb2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Interactions

Nfkb2 interacts with 48 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	extracellular matrix organization, follicular dendritic cell differentiation, ...
Component	Bcl3/NF-kappaB2 complex, cytoplasm, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (76)    Tissues (49)    Images (13)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 27, 28

Assay Type	Results
RNA in situ	61
RT-PCR	15

cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(27) Genomic(12) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000025225 (Evidence)
Entrez Gene	18034 (Evidence)
DFCI	TC1575937, TC1629655, TC1756167
NIA Mouse Gene Index	U019521
PDB	3JV5, 3JV6
Consensus CDS Project	CCDS29874.1
International Mouse Knockout Project Status	Nfkb2

Sequences

Length	Strain/Species
genomic	18034	NCBI Gene Model | MGI Sequence Detail	7354	C57BL/6J
transcript	NM_019408	RefSeq | MGI Sequence Detail	3205	C57BL/6
polypeptide	Q9WTK5	UniProt | EBI | MGI Sequence Detail	899	Not Applicable

All sequences(55) RefSeq(8) UniProt(8)

Polymorphisms

PCR(1) : SNPs within 2kb(34 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000451	NF-kappa-B/Rel/Dorsal
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR011539	Rel homology domain
Protein Ontology	PR:000011178	nuclear factor NF-kappa-B p100 subunit

Graphical View of Protein Domain Structure

References

(Earliest) J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
(Latest) J:209992 Jin J, et al., Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014 Mar 20;40(3):342-54
All references(128)
Disease annotation references (1)