Nfkb2^tm2Brv
Targeted Allele Detail

Summary

• Symbol: Nfkb2^tm2Brv
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 2, Rodrigo Bravo
• MGI ID: MGI:2180306
• Synonyms: Nfkappab2-, NF-kappaB2^-, NF-kappaB2 KO, p100, p52
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^tm2Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76380
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by the replacement of exon 4 with a neomycin resistance cassette via homologous recombination. Radioimmunoprecipitation assay and electrophoretic mobility shift assay (EMSA) did not detect any protein product in thymus and spleen extracts from homozygous mutant animals. (J:76380)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:76380 Caamano JH, et al., Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med. 1998 Jan 19;187(2):185-96
• All: 30 reference(s)