Nfkb2^Lym1
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^Lym1
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Lym1
• MGI ID: MGI:4412046
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^Lym1 page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An ENU mutation resulted in a T to A transversion at base 2854 in the genomic DNA. The mutation is predicted to replace the codon that encodes amino acid 868 with a premature stop codon. The reduced protein size was confirmed by western blot. (J:154812)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:154812 Tucker E, et al., A novel mutation in the Nfkb2 gene generates an NF-kappa B2 'super repressor'. J Immunol. 2007 Dec 1;179(11):7514-22
• All: 9 reference(s)