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Ifnar2
Gene Detail
 Symbol
Name
ID
Ifnar2
interferon (alpha and beta) receptor 2
MGI:1098243
Synonyms Ifnar-2
Feature Type protein coding gene
Genetic Map
Chromosome 16
52.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:91372783-91405589 bp, + strand
From VEGA annotation of GRCm38

  32807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

Gene Tree: Ifnar2

Human
homologs
Human Homolog IFNAR2, interferon (alpha, beta and omega) receptor 2
NCBI Gene ID 3455
neXtProt AC  NX_P48551
Human Synonyms  IFNABR, IFN-alpha-REC, IFNARB, IFN-R
Human Chr (Location)  21q22.11; chr21:33229895-33264513 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IFNAR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(8)
Genomic Mutations involving Ifnar2 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.
 
Interactions
Ifnar2 interacts with 167 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell proliferation, regulation of transcription from RNA polymerase II promoter, ...
Component extracellular region, extracellular space, ...
Function protein kinase binding, type I interferon binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (256)    Tissues (171)    Images (29)
Theiler Stages: 13, 15, 16, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 190
Northern blot 46
Western blot 2
RT-PCR 18
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000040135 (Evidence)
Ensembl Gene ModelENSMUSG00000022971 (Evidence)
Entrez Gene15976 (Evidence)
UniGene6834
DFCITC1578029, TC1583036, TC1698762, TC1704820
DoTSDT.101389482, DT.55219099, DT.97399262, DT.99668727
NIA Mouse Gene IndexU017369
Consensus CDS ProjectCCDS28325.1, CCDS49910.1
International Mouse Knockout Project StatusIfnar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040135 VEGA Gene Model | MGI Sequence Detail 32807 C57BL/6J ±  kb
transcript OTTMUST00000067197 VEGA | MGI Sequence Detail 3047 Not Applicable 
polypeptide OTTMUSP00000033776 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000008923 interferon-alpha/beta receptor beta chain
References (Earliest) J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
(Latest) J:208239 de Weerd NA, et al., Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. Nat Immunol. 2013 Sep;14(9):901-7
All references(74)
Other
accession IDs
MGI:2146482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory