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Ifnar2
Gene Detail
Symbol

Name
ID
Ifnar2
interferon (alpha and beta) receptor 2
MGI:1098243
Synonyms
Ifnar-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:91372783-91405589 bp, + strand
From VEGA annotation of GRCm38

  32807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

HCOP human homology predictions: IFNAR2
Gene Tree: Ifnar2

Human
homologs
IFNAR2, interferon (alpha, beta and omega) receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3455
neXtProt AC: NX_P48551

Human Synonyms: IFNABR, IFN-alpha-REC, IFNARB, IFN-R

Human Chr (Location): 21q22.11; chr21:33229895-33264513 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IFNAR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(10)
Genomic Mutations involving Ifnar2 (5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.
 
Interactions
Ifnar2 interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell proliferation, cytokine-mediated signaling pathway, ...
Component extracellular region, extracellular space, ...
Function protein kinase binding, type I interferon binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (256)    Tissues (176)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 190
Northern blot 46
Western blot 2
RT-PCR 18
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ifnar2.1, LOC100496877    NEW 
Molecular
reagents
All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000040135 (Evidence)
Ensembl Gene Model ENSMUSG00000022971 (Evidence)
Entrez Gene 15976 (Evidence)
UniGene 6834
DFCI TC1704820, TC1698762, TC1583036, TC1578029
DoTS DT.97399262, DT.99668727, DT.55219099, DT.101389482
NIA Mouse Gene Index U017369
Consensus CDS Project CCDS28325.1, CCDS49910.1
International Mouse Phenotyping Consortium Status Ifnar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040135 VEGA Gene Model | MGI Sequence Detail 32807 C57BL/6J ±  kb
transcript OTTMUST00000067197 VEGA | MGI Sequence Detail 3047 Not Applicable 
polypeptide OTTMUSP00000033776 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000008923 interferon-alpha/beta receptor beta chain
References
(Earliest) J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
(Latest) J:213122 Stock AT, et al., Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection. J Exp Med. 2014 May 5;211(5):751-9
All references(76)
Other
accession IDs
MGI:2146482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory