Ifnar2
Gene Detail

Symbol Name ID

Ifnar2 interferon (alpha and beta) receptor 2 MGI:1098243

Synonyms

Ifnar-2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

52.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:91372783-91405589 bp, + strand From VEGA annotation of GRCm38   32807 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken

Gene Tree: Ifnar2

Human homologs

Human Homolog		IFNAR2, interferon (alpha, beta and omega) receptor 2
NCBI Gene ID		3455
neXtProt AC		NX_P48551
Human Synonyms		IFNABR, IFN-alpha-REC, IFNARB, IFN-R
Human Chr (Location)		21q22.11; chr21:33229895-33264513 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human IFNAR2

Mutations, alleles, and phenotypes

All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(12) Targeted(8)
Genomic Mutations involving Ifnar2 (3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.

 

Interactions

Ifnar2 interacts with 167 markers (Mir9-1, Mir9-2, Mir9-3, ...)

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Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell proliferation, regulation of transcription from RNA polymerase II promoter, ...
Component	extracellular region, extracellular space, ...
Function	protein kinase binding, type I interferon binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (256)    Tissues (171)    Images (29)
Theiler Stages: 13, 15, 16, 17, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	190
Northern blot	46
Western blot	2
RT-PCR	18

cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(76) cDNA(74) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000040135 (Evidence)
Ensembl Gene Model	ENSMUSG00000022971 (Evidence)
Entrez Gene	15976 (Evidence)
UniGene	6834
DFCI	TC1578029, TC1583036, TC1698762, TC1704820
DoTS	DT.101389482, DT.55219099, DT.97399262, DT.99668727
NIA Mouse Gene Index	U017369
Consensus CDS Project	CCDS28325.1, CCDS49910.1
International Mouse Knockout Project Status	Ifnar2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040135	VEGA Gene Model | MGI Sequence Detail	32807	C57BL/6J
transcript	OTTMUST00000067197	VEGA | MGI Sequence Detail	3047	Not Applicable
polypeptide	OTTMUSP00000033776	VEGA | MGI Sequence Detail	513	Not Applicable

All sequences(78) RefSeq(6) UniProt(7)

Polymorphisms

SNPs within 2kb(32 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015373	Interferon alpha/beta receptor, beta chain
Protein Ontology	PR:000008923	interferon-alpha/beta receptor beta chain

References

(Earliest) J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
(Latest) J:208239 de Weerd NA, et al., Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. Nat Immunol. 2013 Sep;14(9):901-7
All references(74)

Other accession IDs

MGI:2146482