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Ifnar2 Gene Detail
Summary
  • Symbol
    Ifnar2
  • Name
    interferon (alpha and beta) receptor 2
  • Synonyms
    Ifnar-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098243
    NCBI Gene: 15976
  • Gene Overview
    MyGene.info: IFNAR2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:91372783-91405589 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      32807 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.82 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IFNABR, IFN-alpha-REC, IFNARB, IFN-R, IMD45
  • Links
    NCBI Gene ID: 3455
    neXtProt AC: NX_P48551
    UniProt: P48551

  • Chr Location
    21q22.11; chr21:33229895-33264513 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    256
  • Tissues
    176
  • cDNA Data
    75
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000040135 VEGA Gene Model | MGI Sequence Detail 32807 C57BL/6J ±  kb
    transcript OTTMUST00000067197 VEGA | MGI Sequence Detail 3047 Not Applicable  
    polypeptide OTTMUSP00000033776 VEGA | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      32 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 75
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146482
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
    • Latest
      J:262477 Karki R, et al., IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018 May 3;173(4):920-933.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory