Ifnar2 MGI Mouse Gene Detail - MGI:1098243 - interferon (alpha and beta) receptor 2

Ifnar2 Gene Detail

Symbol

Ifnar2
Name

interferon (alpha and beta) receptor 2
Synonyms

Ifnar-2

Feature Type

protein coding gene
IDs

MGI:1098243
NCBI Gene: 15976
Gene Overview

MyGene.info: IFNAR2

Sequence Map

Chr16:91372783-91405589 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

32807 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 52.82 cM
Mapping Data

4 experiments

Human Ortholog

IFNAR2, interferon alpha and beta receptor subunit 2

Vertebrate Orthologs

9

Human Ortholog

IFNAR2, interferon alpha and beta receptor subunit 2
Orthology source: HomoloGene, HGNC
Synonyms

IFNABR, IFN-alpha-REC, IFNARB, IFN-R, IMD45
Links

HGNC:5433

NCBI Gene ID: 3455

neXtProt AC: NX_P48551
Chr Location

21q22.11; chr21:33229895-33264513 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 49242
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;2 dog;1 chicken
HCOP

human homology predictions: IFNAR2
Gene Tree

Ifnar2

Diseases

2 with human IFNAR2 associations

				Human Disease	Mouse Models
				Hepatitis B Virus, Susceptibility to OMIM: 610424
				Immunodeficiency 45; IMD45 OMIM: 616669

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (ENU)

1
Gene trapped

12
Targeted

12
Genomic Mutations

6 involving Ifnar2
Incidental Mutations

Mutagenetix , APF , CvDC

Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.

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All GO Annotations

16
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

256
Tissues

176
cDNA Data

74
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ifnar2.1, ifnar2.2

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Ifnar2 interacts with 166 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

76
RefSeq

10
UniProt

7
CCDS

CCDS28325.1, CCDS49910.1
UniGene

6834

			Length	Strain/Species	Flank
genomic	OTTMUSG00000040135	VEGA Gene Model \| MGI Sequence Detail	32807	C57BL/6J	± kb
transcript	OTTMUST00000067197	VEGA \| MGI Sequence Detail	3047	Not Applicable
polypeptide	OTTMUSP00000033776	VEGA \| MGI Sequence Detail	513	Not Applicable

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SNPs within 2kb

32 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000008923 interferon-alpha/beta receptor beta chain
InterPro Domains

IPR003961 Fibronectin type III

IPR013783 Immunoglobulin-like fold

IPR015373 Interferon/interleukin receptor domain

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All nucleic 76

cDNA 74

Primer pair 2

Microarray probesets 6

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MGI:2146482

Summaries

All 78

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 36
Earliest

J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
Latest

J:233318 Jackson SW, et al., B cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016 May 2;213(5):733-50

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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