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Ifnar2 Gene Detail
Summary
  • Symbol
    Ifnar2
  • Name
    interferon (alpha and beta) receptor 2
  • Synonyms
    Ifnar-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098243
    NCBI Gene: 15976
  • Gene Overview
    MyGene.info: IFNAR2
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91372783-91405589 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098243
 protein coding gene Chr16:91372783-91405589 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023038
 protein coding gene Chr16:92375431-92410061 (+)
A/J MGP_AJ_G0023006
 protein coding gene Chr16:88061137-88093925 (+)
AKR/J MGP_AKRJ_G0022976
 protein coding gene Chr16:90714259-90750321 (+)
BALB/cJ MGP_BALBcJ_G0023008
 protein coding gene Chr16:88577168-88612722 (+)
C3H/HeJ MGP_C3HHeJ_G0022769
 protein coding gene Chr16:91279191-91314862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023455
 protein coding gene Chr16:95367320-95403604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020957
 protein coding gene Chr16:85762281-85793696 (+)
CAST/EiJ MGP_CASTEiJ_G0022288
 protein coding gene Chr16:91844098-91879534 (+)
CBA/J MGP_CBAJ_G0022738
 protein coding gene Chr16:99417435-99459801 (+)
DBA/2J MGP_DBA2J_G0022872
 protein coding gene Chr16:87960813-87993329 (+)
FVB/NJ MGP_FVBNJ_G0022846
 protein coding gene Chr16:87088068-87120144 (+)
LP/J MGP_LPJ_G0022942
 protein coding gene Chr16:92085071-92119099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022867
 protein coding gene Chr16:103995777-104030509 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023473
 protein coding gene Chr16:91234443-91269588 (+)
PWK/PhJ MGP_PWKPhJ_G0022033
 protein coding gene Chr16:88137495-88172015 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021863
 protein coding gene Chr16:90789894-90824054 (+)
WSB/EiJ MGP_WSBEiJ_G0022340
 protein coding gene Chr16:91474659-91509923 (+)



Homology
more
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IFNABR, IFN-alpha-REC, IFNARB, IFN-R, IMD45
  • Links
    NCBI Gene ID: 3455
    neXtProt AC: NX_P48551
    UniProt: P48551

  • Chr Location
    21q22.11; chr21:33229895-33264513 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human IFNAR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    176
  • cDNA Data
    75
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15976 NCBI Gene Model | MGI Sequence Detail 32807 C57BL/6J ±  kb
    transcript NM_010509 RefSeq | MGI Sequence Detail 3051 C57BL/6  
    polypeptide O35664 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 75
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146482
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 51
    • Earliest
      J:40624 Beebe AM, et al., Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 1997 May;6(5):551-7
    • Latest
      J:296686 Karki R, et al., COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-alpha and IFN-gamma in triggering inflammation, tissue damage, and death. bioRxiv. 2020 Nov;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory