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Pik3cd
Gene Detail
Symbol

Name
ID
Pik3cd
phosphatidylinositol 3-kinase catalytic delta polypeptide
MGI:1098211
Synonyms
2410099E07Rik, 2610208K16Rik, p110delta
Feature Type
protein coding gene
Genetic Map
Chromosome 4
80.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:149649168-149702571 bp, - strand
From VEGA annotation of GRCm38

  53404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PIK3CD
Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cd

Human
homologs
PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5293
neXtProt AC: NX_O00329

Human Synonyms: APDS, IMD14, p110D, P110DELTA, PI3K

Human Chr (Location): 1p36.2; chr1:9629889-9729114 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PIK3CD

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(9) Targeted(8)
Genomic Mutations involving Pik3cd (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
 
Interactions
Pik3cd interacts with 198 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (243)    Tissues (126)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 207
RT-PCR 36
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pik3cd    NEW 
Molecular
reagents
All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000010264 (Evidence)
Ensembl Gene Model ENSMUSG00000039936 (Evidence)
Entrez Gene 18707 (Evidence)
UniGene 229108
DFCI TC1572569, TC1606478, TC1678150, TC1683893
DoTS DT.101304999, DT.101405035, DT.101405040, DT.110834576, DT.111126161, DT.91375213, DT.94166534, DT.94166538, DT.99864449, DT.99864456
NIA Mouse Gene Index U025808
EC 2.7.1.153
PDB 2WXF, 2WXG, 2WXH, 2WXI, 2WXJ, 2WXK, 2WXL, 2WXM, 2WXN, 2WXO, 2WXP, 2WXQ, 2WXR, 2X38, 4AJW, 4XE0
Consensus CDS Project CCDS51380.1, CCDS51381.1, CCDS51382.1, CCDS51383.1, CCDS51384.1
International Mouse Phenotyping Consortium Status Pik3cd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010264 VEGA Gene Model | MGI Sequence Detail 53404 C57BL/6J ±  kb
transcript OTTMUST00000023877 VEGA | MGI Sequence Detail 4921 Not Applicable 
polypeptide OTTMUSP00000010948 VEGA | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(177) RefSeq(68) UniProt(14)
Polymorphisms
SNPs within 2kb(438 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 domain
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase, C2 domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000012721 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
References
(Earliest) J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
(Latest) J:222882 Doisne JM, et al., Immunomodulation of Selective Naive T Cell Functions by p110delta Inactivation Improves the Outcome of Mismatched Cell Transplantation. Cell Rep. 2015 Feb 4;
All references(129)
Other
accession IDs
MGI:1917688, MGI:1925744, MGI:2140589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory