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Pik3cd Gene Detail
Summary
  • Symbol
    Pik3cd
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Synonyms
    2410099E07Rik, 2610208K16Rik, p110delta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098211
    NCBI Gene: 18707
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149733625-149787023 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 80.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098211
 protein coding gene Chr4:149733625-149787028 (-)
129S1/SvImJ ENSMUSG00200042849
 protein coding gene Chr4:140774912-140828326 (-)
A/J ENSMUSG00195015720
 protein coding gene Chr4:142430703-142483883 (-)
AKR/J ENSMUSG00220045023
 protein coding gene Chr4:142018219-142071637 (-)
BALB/cJ ENSMUSG00180044633
 protein coding gene Chr4:140113317-140166481 (-)
C3H/HeJ ENSMUSG00175016251
 protein coding gene Chr4:143398621-143452037 (-)
C57BL/6NJ ENSMUSG00215021640
 protein coding gene Chr4:142237735-142291141 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026820
 protein coding gene Chr4:139526842-139582910 (-)
CAST/EiJ ENSTCUG00005031361
 protein coding gene Chr4:146073500-146127489 (-)
CBA/J ENSMUSG00210004268
 protein coding gene Chr4:142050259-142103668 (-)
DBA/2J ENSMUSG00185013798
 protein coding gene Chr4:145611757-145665170 (-)
FVB/NJ ENSMUSG00205019816
 protein coding gene Chr4:140504648-140558199 (-)
JF1/MsJ ENSUMUG00000006842
 protein coding gene Chr4:148626908-148680484 (-)
LP/J ENSMUSG00230014841
 protein coding gene Chr4:152346427-152399590 (-)
NOD/ShiLtJ ENSMUSG00190003260
 protein coding gene Chr4:141718600-141771788 (-)
NZO/HlLtJ ENSMUSG00225023292
 protein coding gene Chr4:156345278-156398420 (-)
PWK/PhJ ENSLUMG00010045043
 protein coding gene Chr4:140901287-140954706 (-)
SPRET/EiJ ENSMSPG00010021723
 protein coding gene Chr4:142824033-142877649 (-)
WSB/EiJ ENSIUOG00005041214
 protein coding gene Chr4:139884124-139937455 (-)



Homology
more
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Synonyms
    APDS, IMD14, IMD14A, IMD14B, p110D, P110DELTA, PI3K, PI3Kdelta, ROCHIS
  • Links
    NCBI Gene ID: 5293
    UniProt: O00329

  • Chr Location
    1p36.22; chr1:9627258-9730117 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pik3cd mouse models; 4 with human PIK3CD associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    89 phenotypes from 8 alleles in 13 genetic backgrounds
    23 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    128
  • cDNA Data
    74
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18707 NCBI Gene Model | MGI Sequence Detail 53399 C57BL/6J ±  kb
    transcript NM_008840 RefSeq | MGI Sequence Detail 5102 C57BL/6  
    polypeptide O35904 UniProt | EBI | MGI Sequence Detail 1043 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 74
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917688, MGI:1925744, MGI:2140589
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 12
      Phenotypes 128
    • Earliest
      J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
    • Latest
      J:380970 Golec DP, et al., A PI3Kdelta-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. J Exp Med. 2026 Apr 6;223(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory