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Pik3cd Gene Detail
Summary
  • Symbol
    Pik3cd
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Synonyms
    2410099E07Rik, 2610208K16Rik, p110delta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098211
    NCBI Gene: 18707
  • Gene Overview
    MyGene.info: PIK3CD
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:149649168-149702571 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53404 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 80.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APDS, IMD14, p110D, P110DELTA, PI3K
  • Links
    NCBI Gene ID: 5293
    neXtProt AC: NX_O00329
    UniProt: O00329

  • Chr Location
    1p36.22; chr1:9629889-9729114 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 7 alleles in 11 genetic backgrounds
    23 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010264 VEGA Gene Model | MGI Sequence Detail 53404 C57BL/6J ±  kb
    transcript OTTMUST00000023877 VEGA | MGI Sequence Detail 4921 Not Applicable  
    polypeptide OTTMUSP00000010948 VEGA | MGI Sequence Detail 1047 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      281 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917688, MGI:1925744, MGI:2140589
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 90
    • Earliest
      J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
    • Latest
      J:254898 Uehara M, et al., Regulation of T cell alloimmunity by PI3Kgamma and PI3Kdelta. Nat Commun. 2017 Oct 16;8(1):951

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory