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Pik3cd
Gene Detail
 Symbol
Name
ID
Pik3cd
phosphatidylinositol 3-kinase catalytic delta polypeptide
MGI:1098211
Synonyms 2410099E07Rik, 2610208K16Rik, p110delta
Feature Type protein coding gene
Genetic Map
Chromosome 4
80.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:149649168-149702571 bp, - strand
From VEGA annotation of GRCm38

  53404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cd

Human
homologs
Human Homolog PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
NCBI Gene ID 5293
neXtProt AC  NX_O00329
Human Synonyms  APDS, IMD14, p110D, P110DELTA, PI3K
Human Chr (Location)  1p36.2; chr1:9629889-9729114 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIK3CD
Alleles
and
phenotypes
All alleles(16) : Gene trapped(9) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process B cell activation, B cell homeostasis, ...
Component cytoplasm, phosphatidylinositol 3-kinase complex, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (243)    Tissues (126)    Images (26)
Theiler Stages: 2, 3, 22, 23
Assay TypeResults
RNA in situ 207
RT-PCR 36
cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000010264 (Evidence)
Ensembl Gene ModelENSMUSG00000039936 (Evidence)
Entrez Gene18707 (Evidence)
UniGene229108
DFCITC1572569, TC1606478, TC1678150, TC1683893
DoTSDT.101304999, DT.101405035, DT.101405040, DT.110834576, DT.111126161, DT.91375213, DT.94166534, DT.94166538, DT.99864449, DT.99864456
NIA Mouse Gene IndexU025808
EC2.7.1.153
PDB2WXF, 2WXG, 2WXH, 2WXI, 2WXJ, 2WXK, 2WXL, 2WXM, 2WXN, 2WXO, 2WXP, 2WXQ, 2WXR, 4AJW, 2X38
Consensus CDS ProjectCCDS51380.1, CCDS51381.1, CCDS51382.1, CCDS51383.1, CCDS51384.1
International Mouse Knockout Project StatusPik3cd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010264 VEGA Gene Model | MGI Sequence Detail 53404 C57BL/6J ±  kb
transcript OTTMUST00000023877 VEGA | MGI Sequence Detail 4921 Not Applicable 
polypeptide OTTMUSP00000010948 VEGA | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(175) RefSeq(66) UniProt(14)
Polymorphisms SNPs within 2kb(438 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012721 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
References (Earliest) J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
(Latest) J:210009 Steinbach EC, et al., Innate PI3K p110delta regulates Th1/Th17 development and microbiota-dependent colitis. J Immunol. 2014 Apr 15;192(8):3958-68
All references(125)
Other
accession IDs
MGI:1917688, MGI:1925744, MGI:2140589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory