Pik3cd
Gene Detail

Symbol Name ID

Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide MGI:1098211

Synonyms

2410099E07Rik, 2610208K16Rik, p110delta

Feature Type

protein coding gene

Genetic Map

Chromosome 4

80.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:149649168-149702571 bp, - strand From VEGA annotation of GRCm38   53404 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pik3cd ± 2 cM)

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cd

Human ortholog

PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta NCBI Gene ID 5293
Human Synonyms: p110D, P110DELTA, PI3K
Human Chr1:9711790-9789172 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	B cell activation, B cell homeostasis, ...
Component	cytoplasm, phosphatidylinositol 3-kinase complex, ...
Function	1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (243)    Tissues (126)    Images (26)
Theiler Stages: 2, 3, 22, 23

Assay Type	Results
RNA in situ	207
RT-PCR	36

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000010264 (Evidence)
Ensembl Gene Model	ENSMUSG00000039936 (Evidence)
Entrez Gene	18707 (Evidence)
UniGene	229108
DFCI	TC1572569, TC1606478, TC1678150, TC1683893
DoTS	DT.101304999, DT.101405035, DT.101405040, DT.110834576, DT.111126161, DT.91375213, DT.94166534, DT.94166538, DT.99864449, DT.99864456
NIA Mouse Gene Index	U025808
EC	2.7.1.153
PDB	2WXF, 2WXG, 2WXH, 2WXI, 2WXJ, 2WXK, 2WXL, 2WXM, 2WXN, 2WXO, 2WXP, 2WXQ, 2WXR, 2X38, 4AJW
Consensus CDS Project	CCDS51380.1, CCDS51381.1, CCDS51382.1, CCDS51383.1, CCDS51384.1
International Mouse Knockout Project Status	Pik3cd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010264	VEGA Gene Model | MGI Sequence Detail	53404	C57BL/6J
transcript	OTTMUST00000023877	VEGA | MGI Sequence Detail	4921	Not Applicable
polypeptide	OTTMUSP00000010948	VEGA | MGI Sequence Detail	1047	Not Applicable

All sequences(121) RefSeq(12) UniProt(14)

Polymorphisms

SNPs(227 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro	IPR002420	Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro	IPR015433	Phosphatidylinositol Kinase
InterPro	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000012721	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform

References

(Earliest) J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
(Latest) J:194209 Finlay DK, et al., PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med. 2012 Dec 17;209(13):2441-53
All references(119)

Other accession IDs

MGI:1917688, MGI:1925744, MGI:2140589