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Pik3cd
Gene Detail
Symbol

Name
ID
Pik3cd
phosphatidylinositol 3-kinase catalytic delta polypeptide
MGI:1098211
Synonyms
2410099E07Rik, 2610208K16Rik, p110delta
Feature Type
protein coding gene
Genetic Map
Chromosome 4
80.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:149649168-149702571 bp, - strand
From VEGA annotation of GRCm38

  53404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3686  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cd

Human
homologs
Human Homolog PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
NCBI Gene ID 5293
neXtProt AC  NX_O00329
Human Synonyms  APDS, IMD14, p110D, P110DELTA, PI3K
Human Chr (Location)  1p36.2; chr1:9629889-9729114 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIK3CD
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(9) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
 
Interactions
Pik3cd interacts with 198 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (243)    Tissues (126)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 207
RT-PCR 36
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) cDNA(73) Primer pair(1)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010264 VEGA Gene Model | MGI Sequence Detail 53404 C57BL/6J ±  kb
transcript OTTMUST00000023877 VEGA | MGI Sequence Detail 4921 Not Applicable 
polypeptide OTTMUSP00000010948 VEGA | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(188) RefSeq(66) UniProt(27)
Polymorphisms
SNPs within 2kb(438 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012721 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
References
(Earliest) J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
(Latest) J:213482 Ali K, et al., Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;510(7505):407-11
All references(129)
Other
accession IDs
MGI:1917688, MGI:1925744, MGI:2140589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory