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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
MGI:1098211
89 phenotypes from 8 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3cdem1.1Pls/Pik3cd+
Not Specified 		abnormal B cell differentiation J:282486
abnormal class switch recombination J:282486
abnormal follicular B cell physiology J:282486
abnormal gut flora balance J:282486
abnormal gut-associated lymphoid tissue morphology J:282486
abnormal IgG1 level J:282486
abnormal immune tolerance J:282486
abnormal innate immunity J:282486
abnormal lung morphology J:282486
abnormal lymph node germinal center morphology J:282486
abnormal mesenteric lymph node morphology J:282486
abnormal Peyer's patch germinal center morphology J:282486
abnormal Peyer's patch morphology J:282486
abnormal plasmablast number J:282486
abnormal small intestine morphology J:282486
decreased B cell apoptosis J:282486
decreased CD4-positive, alpha-beta T cell number J:282486
decreased follicular B cell number J:282486
decreased leukocyte cell number J:282486
decreased naive B cell number J:282486
enlarged lymph nodes J:282486
enlarged spleen J:282486
impaired humoral immune response J:282486
increased activated T cell number J:282486
increased anti-double stranded DNA antibody level J:282486
increased anti-nuclear antigen antibody level J:282486
increased B cell proliferation J:282486
increased B-1a cell number J:282486
increased germinal center B cell number J:282486
increased IgA level J:282486
increased IgG level J:282486
increased IgM level J:282486
increased lymphocyte activation involved in immune response J:282486
increased lymphocyte cell number J:282486
increased marginal zone B cell number J:282486
increased plasma cell number J:282486
increased response to antigen J:282486
increased T follicular helper cell number J:282486
increased transitional stage B cell number J:282486
increased transitional stage T1 B cell number J:282486
lymph node hyperplasia J:282486
lymphoid hyperplasia J:282486
spleen hyperplasia J:282486
Pik3cdGt(OST451938)Lex/Pik3cdGt(OST451938)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		decreased IgG1 level J:103485
increased leukocyte cell number J:103485
increased lymphocyte cell number J:103485
Pik3cdm1Btlr/Pik3cdm1Btlr
C57BL/6J-Pik3cdm1Btlr 		abnormal humoral immune response J:213049
Pik3cdm2Btlr/Pik3cd+
C57BL/6J-Pik3cdm2Btlr 		decreased B-1 B cell number J:236693
decreased IgG level J:236693
decreased IgM level J:236693
decreased response to antigen J:236693
impaired hematopoiesis J:236693
Pik3cdm2Btlr/Pik3cdm2Btlr
C57BL/6J-Pik3cdm2Btlr 		decreased B-1 B cell number J:236693
decreased B-1a cell number J:236693
decreased IgG level J:236693
decreased IgM level J:236693
decreased response to antigen J:236693
impaired hematopoiesis J:236693
increased circulating interferon-alpha level J:236693
increased IgE level J:236693
increased response to antigen J:236693
increased susceptibility to Herpesvirales infection J:236693
Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
B6.129P2-Pik3cdtm1.1Bvan 		abnormal platelet aggregation J:114310
Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
involves: 129P2/OlaHsd 		normal cardiovascular system phenotype J:136236
Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
involves: 129P2/OlaHsd * BALB/c 		abnormal B cell differentiation J:78412
abnormal intestinal epithelium morphology J:78412
abnormal intestinal mucosa morphology J:78412
abnormal Peyer's patch germinal center morphology J:78412
absent spleen germinal center J:78412
crypts of Lieberkuhn abscesses J:78412
decreased B-1 B cell number J:78412
decreased IgA level J:78412
decreased IgM level J:78412
decreased immunoglobulin level J:78412
increased neutrophil cell number J:78412
intestinal inflammation J:78412
spleen hypoplasia J:78412
Pik3cdtm1Jni/Pik3cdtm1Jni
involves: 129P2/OlaHsd 		abnormal B cell calcium ion homeostasis J:80614
abnormal humoral immune response J:80614
absent B-1 B cells J:80614
absent spleen germinal center J:80614
decreased B cell number J:80614
decreased B cell proliferation J:80614
decreased immunoglobulin level J:80614
decreased mature B cell number J:80614
small lymph nodes J:80614
small spleen J:80614
Pik3cdtm1Jni/Pik3cdtm1Jni
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:124330
Pik3cdtm1Tnr/Pik3cdtm1Tnr
B6.129S4-Pik3cdtm1Tnr 		decreased inflammatory response J:134324
decreased susceptibility to induced arthritis J:134324
Pik3cdtm1Tnr/Pik3cdtm1Tnr
involves: 129S4/SvJae 		abnormal B cell physiology J:113491
abnormal humoral immune response J:79133
decreased B cell number J:79133
decreased B cell proliferation J:79133, J:113491
decreased B-1 B cell number J:79133
decreased B-2 B cell number J:79133
decreased IgG1 level J:79133
decreased IgG2a level J:79133
decreased IgG2b level J:79133
decreased IgG3 level J:79133
decreased IgM level J:79133
decreased marginal zone B cell number J:79133
Pik3cdtm1Tnr/Pik3cdtm1Tnr
involves: 129S4/SvJae * C57BL/6J 		abnormal platelet aggregation J:114310
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:164283
increased IgE level J:164283
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal adaptive immunity J:164283
abnormal humoral immune response J:164283
decreased CD4-positive, alpha-beta T cell number J:164283
decreased CD8-positive, alpha-beta T cell number J:164283
decreased germinal center B cell number J:164283
decreased IgG1 level J:164283
decreased spleen germinal center number J:164283
decreased spleen germinal center size J:164283
decreased T cell number J:164283
decreased T follicular helper cell number J:164283
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal humoral immune response J:164283
decreased germinal center B cell number J:164283
decreased IgG1 level J:164283
decreased spleen germinal center number J:164283
decreased T follicular helper cell number J:164283
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory