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Arx
Gene Detail
Symbol

Name
ID
Arx
aristaless related homeobox
MGI:1097716
Feature Type
protein coding gene
Genetic Map
Chromosome X
41.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:93286445-93298357 bp, + strand
From VEGA annotation of GRCm38

  11913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

HCOP human homology predictions: ARX
Gene Tree: Arx

Human
homologs
ARX, aristaless related homeobox
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 170302
neXtProt AC: NX_Q96QS3

Human Synonyms: CT121, EIEE1, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS

Human Chr (Location): Xp21.3; chrX:25003694-25015948 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human ARX

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
 
Males hemizygous for targeted null mutations die perinatally. Male mice hemizygous for various alleles with point mutations or triple repeat expansion exhibit defective GABAergic neuron migration and numbers, seizures, and/or behavioral defects.
 
Human Diseases Modeled in Mice Using Arx (2)    Mutations Annotated to Human Diseases (5)   
Interactions
Arx interacts with 270 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process axon guidance, cell differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (554)    Tissues (229)    Images (143)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 539
Northern blot 1
RT-PCR 14
cDNA source data(31)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase arx ; ZFIN arxa    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(31) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017972 (Evidence)
Ensembl Gene Model ENSMUSG00000035277 (Evidence)
Entrez Gene 11878 (Evidence)
UniGene 275547
DFCI TC1756562, TC1580899
DoTS DT.60103879, DT.101365945
NIA Mouse Gene Index U020009
Consensus CDS Project CCDS30271.1
International Mouse Phenotyping Consortium Status Arx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017972 VEGA Gene Model | MGI Sequence Detail 11913 C57BL/6J ±  kb
transcript OTTMUST00000043410 VEGA | MGI Sequence Detail 2737 Not Applicable 
polypeptide OTTMUSP00000019501 VEGA | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000004334 homeobox protein ARX
References
(Earliest) J:42033 Miura H, et al., Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate. Mech Dev. 1997 Jul;65(1-2):99-109
(Latest) J:218837 Song H, et al., Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015 Feb 15;398(2):280-91
All references(132)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory