About   Help   FAQ
Arx
Gene Detail
 Symbol
Name
ID
Arx
aristaless related homeobox
MGI:1097716
Feature Type protein coding gene
Genetic Map
Chromosome X
41.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:93286507-93298357 bp, + strand
From VEGA annotation of GRCm38

  11851 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Gene Tree: Arx

Human
homologs
Human Homolog ARX, aristaless related homeobox
NCBI Gene ID 170302
neXtProt AC  NX_Q96QS3
Human Synonyms  CT121, EIEE1, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS
Human Chr (Location)  Xp21.3; chrX:25003694-25015948 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human ARX
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Males hemizygous for targeted null mutations die perinatally. Male mice hemizygous for various alleles with point mutations or triple repeat expansion exhibit defective GABAergic neuron migration and numbers, seizures, and/or behavioral defects.
 
Human Diseases Modeled Using Mouse Arx (2)    Alleles Annotated to Human Diseases(5)   
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process axon guidance, cell differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (548)    Tissues (226)    Images (143)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 539
Northern blot 1
RT-PCR 8
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(31) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017972 (Evidence)
Ensembl Gene ModelENSMUSG00000035277 (Evidence)
Entrez Gene11878 (Evidence)
UniGene275547
DFCITC1580899, TC1756562
DoTSDT.101365945, DT.60103879
NIA Mouse Gene IndexU020009
Consensus CDS ProjectCCDS30271.1
International Mouse Knockout Project StatusArx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017972 VEGA Gene Model | MGI Sequence Detail 11851 C57BL/6J ±  kb
transcript OTTMUST00000043409 VEGA | MGI Sequence Detail 2870 Not Applicable 
polypeptide OTTMUSP00000019500 VEGA | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000004334 homeobox protein ARX
References (Earliest) J:42033 Miura H, et al., Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate. Mech Dev. 1997 Jul;65(1-2):99-109
(Latest) J:206228 Lee K, et al., Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation. Hum Mol Genet. 2014 Feb 15;23(4):1084-94
All references(121)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory