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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Arx
aristaless related homeobox
MGI:1097716
95 phenotypes from 9 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Arxtm1.1Ics/Y
involves: 129S2/SvPas * C57BL/6J * C57BL/6N
abnormal brain interneuron morphology J:262482
abnormal gait J:262482
abnormal nervous system electrophysiology J:262482
abnormal neuronal migration J:262482
abnormal voluntary movement J:262482
decreased neuron number J:262482
enhanced coordination J:262482
impaired balance J:262482
impaired contextual conditioning behavior J:262482
increased locomotor activity J:262482
increased vertical activity J:262482
muscle spasm J:262482
Arxtm1.1Jno/Y
involves: 129S7/SvEvBrd * C57BL/6J
abnormal associative learning J:151082
abnormal brain interneuron morphology J:151082
abnormal brain wave pattern J:151082
abnormal cerebral cortex morphology J:151082
abnormal hippocampus CA4 region morphology J:151082
abnormal somatosensory cortex morphology J:151082
abnormal striatum morphology J:151082
clonic seizures J:151082
decreased aggression towards mice J:151082
decreased anxiety-related response J:151082
decreased thermal nociceptive threshold J:151082
normal endocrine/exocrine gland phenotype J:151082
enhanced coordination J:151082
impaired contextual conditioning behavior J:151082
impaired cued conditioning behavior J:151082
myoclonus J:151082
seizures J:151082
tonic-clonic seizures J:151082
Arxtm1.1Jno/Arxtm1.1Jno
involves: 129S7/SvEvBrd * C57BL/6J
normal endocrine/exocrine gland phenotype J:151082
myoclonus J:151082
Arxtm1Gldn/Y
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:138839
Arxtm1Gldn/Arx+
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
abnormal brain interneuron morphology J:148311
abnormal brain wave pattern J:148311
clonic seizures J:148311
convulsive seizures J:148311
normal nervous system phenotype J:148311
sporadic seizures J:148311
tonic-clonic seizures J:148311
Arxtm1Gldn/Arxtm1Gldn
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:138839
Arxtm1Gldn/Y
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
abnormal brain interneuron morphology J:148311
abnormal brain wave pattern J:148311
clonic seizures J:148311
decreased survivor rate J:148311
normal nervous system phenotype J:148311
postnatal lethality, incomplete penetrance J:148311
sporadic seizures J:148311
tonic-clonic seizures J:148311
Arxtm1Gldn/Y
Tg(Pou3f4-cre)32Cren/0
involves: 129/Sv * C57BL/6 * CD-1
abnormal cerebral cortex morphology J:138839
abnormal olfactory bulb morphology J:138839
decreased brain size J:138839
Arxtm1Kki/Y
involves: 129P2/OlaHsd * C57BL
abnormal brain internal capsule morphology J:79871
abnormal central medial nucleus morphology J:79871
abnormal corpus callosum morphology J:79871
abnormal cortical marginal zone morphology J:79871
abnormal cortical plate morphology J:79871
abnormal cortical ventricular zone morphology J:79871
abnormal dentate gyrus morphology J:79871
abnormal fetal Leydig cell differentiation J:79871
abnormal forebrain development J:79871
abnormal glutaminergic neuron morphology J:79871
abnormal hippocampus CA3 region morphology J:79871
abnormal hippocampus development J:79871
abnormal neocortex morphology J:79871
abnormal nervous system tract morphology J:79871
abnormal neuronal migration J:79871
abnormal olfactory bulb morphology J:79871
abnormal telencephalon development J:79871
abnormal telencephalon morphology J:79871
abnormal thalamus morphology J:79871
absent hippocampal commissure J:79871
absent hippocampal fimbria J:79871
decreased brain size J:79871
enlarged seminiferous tubules J:79871
enlarged third ventricle J:79871
neonatal lethality, complete penetrance J:79871
seminal vesicle hypoplasia J:79871
small olfactory bulb J:79871
small testis J:79871
thin cortical plate J:79871
Arxtm1Pgr/Y
involves: 129/Sv * NMRI
abnormal pancreatic delta cell morphology J:86206
absent pancreatic alpha cells J:86206
dehydration J:86206
hypoglycemia J:86206
increased pancreatic beta cell number J:86206
increased pancreatic delta cell number J:86206
postnatal growth retardation J:86206
postnatal lethality, complete penetrance J:86206
weakness J:86206
Arxtm2Kki/Y
involves: 129S/SvEv * C57BL/6J
abnormal neuronal migration J:152416
abnormal postnatal subventricular zone morphology J:152416
abnormal ventral striatum morphology J:152416
decreased brain size J:152416
neonatal lethality, complete penetrance J:152416
small olfactory bulb J:152416
thin cortical plate J:152416
Arxtm3Kki/Y
involves: 129S/SvEv * C57BL/6J
abnormal cholinergic neuron morphology J:152416
abnormal neuronal migration J:152416
abnormal spatial learning J:152416
hyperactivity J:152416
impaired coordination J:152416
impaired passive avoidance behavior J:152416
increased anxiety-related response J:152416
increased susceptibility to induced morbidity/mortality J:152416
increased susceptibility to pharmacologically induced seizures J:152416
loss of GABAergic neurons J:152416
normal mortality/aging J:152416
Arxtm4Kki/Y
involves: 129S/SvEv * C57BL/6J
abnormal cholinergic neuron morphology J:152416
abnormal neuronal migration J:152416
abnormal spatial learning J:152416
abnormal spike wave discharge J:152416
hyperactivity J:152416
impaired coordination J:152416
impaired passive avoidance behavior J:152416
increased anxiety-related response J:152416
loss of GABAergic neurons J:152416
premature death J:152416
seizures J:152416
tonic seizures J:152416
Arxtm4Kki/Y
involves: 129S/SvEv * C57BL/6NHsd
abnormal motor capabilities/coordination/movement J:260340
abnormal response to social novelty J:260340
abnormal social investigation J:260340
decreased body weight J:260340
decreased exploration in new environment J:260340
decreased fear-related response J:260340
decreased locomotor activity J:260340
impaired spatial learning J:260340
increased anxiety-related response J:260340
increased exploration in new environment J:260340
myoclonus J:260340
postnatal lethality, incomplete penetrance J:260340
premature death J:260340
social withdrawal J:260340
Arxtm5Kki/Y
involves: 129S/SvEv * C57BL/6J
abnormal brain interneuron morphology J:152416
normal nervous system phenotype J:152416
Arxtm5Kki/Y
involves: 129S/SvEv * C57BL/6NHsd
abnormal motor capabilities/coordination/movement J:260340
abnormal response to social novelty J:260340
abnormal social investigation J:260340
decreased body weight J:260340
decreased exploration in new environment J:260340
decreased fear-related response J:260340
decreased locomotor activity J:260340
impaired spatial learning J:260340
increased anxiety-related response J:260340
increased exploration in new environment J:260340
myoclonus J:260340
postnatal lethality, incomplete penetrance J:260340
premature death J:260340
seizures J:260340
social withdrawal J:260340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory