Symbol
Name
ID

Arx
aristaless related homeobox
MGI:1097716

Phenotype annotations related to behavior/neurological

Darker colors indicate more annotations

Human Phenotypes	Drooling	Feeding difficulties in infancy	Urinary incontinence	Atypical behavior	Weak voice
Disease(s) Associated with ARX	Drooling	Feeding difficulties in infancy	Urinary incontinence	Atypical behavior	Weak voice
non-syndromic X-linked intellectual disability ARX-related
Partington syndrome
syndromic X-linked intellectual disability Hedera type
X-linked lissencephaly 2

Mouse Phenotypes

increased susceptibility to pharmacologically induced seizures

abnormal associative learning

impaired passive avoidance behavior

impaired contextual conditioning behavior

impaired cued conditioning behavior

decreased exploration in new environment

increased exploration in new environment

abnormal spatial learning

impaired spatial learning

decreased aggression towards mice

decreased anxiety-related response

increased anxiety-related response

decreased fear-related response

abnormal response to social novelty

abnormal motor capabilities/coordination/movement

enhanced coordination

impaired balance

impaired coordination

weakness

abnormal voluntary movement

abnormal gait

increased vertical activity

decreased locomotor activity

increased locomotor activity

hyperactivity

decreased thermal nociceptive threshold

abnormal social investigation

social withdrawal

seizures

convulsive seizures

clonic seizures

myoclonus

tonic seizures

tonic-clonic seizures

abnormal spike wave discharge

sporadic seizures

Availability

Mouse Genotype

Arx^tm1.1Jno/Arx^tm1.1Jno

Arx^tm1.1Ics/Y

Arx^tm1.1Jno/Y

Arx^tm1Pgr/Y

Arx^tm3Kki/Y

Arx^tm4Kki/Y

Arx^tm5Kki/Y

Arx^tm1Gldn/Arx⁺
Tg(mI56i-cre,EGFP)1Kc/0 (conditional)

Arx^tm1Gldn/Y
Tg(mI56i-cre,EGFP)1Kc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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