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Nrxn1 Gene Detail
Summary
  • Symbol
    Nrxn1
  • Name
    neurexin I
  • Synonyms
    1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096391
    NCBI Gene: 18189
  • Gene Overview
    MyGene.info: NRXN1
  • Alliance
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:90033631-91093071 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 59.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096391
protein coding gene Chr17:90033631-91093102 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024115
protein coding gene Chr17:93577552-94701577 (-)
A/J MGP_AJ_G0024075
protein coding gene Chr17:90546053-91623050 (-)
AKR/J MGP_AKRJ_G0024044
protein coding gene Chr17:92041808-93137528 (-)
BALB/cJ MGP_BALBcJ_G0024076
protein coding gene Chr17:90341870-91432210 (-)
C3H/HeJ MGP_C3HHeJ_G0023841
protein coding gene Chr17:92948374-94066350 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024521
protein coding gene Chr17:96829722-97953278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021959
protein coding gene Chr17:85491118-86564748 (-)
CAST/EiJ MGP_CASTEiJ_G0023320
protein coding gene Chr17:93850651-94994067 (-)
CBA/J MGP_CBAJ_G0023814
protein coding gene Chr17:100865919-102040555 (-)
DBA/2J MGP_DBA2J_G0023943
protein coding gene Chr17:88904075-89985020 (-)
FVB/NJ MGP_FVBNJ_G0023909
protein coding gene Chr17:88450283-89525485 (-)
LP/J MGP_LPJ_G0024027
protein coding gene Chr17:94354902-95473686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023937
protein coding gene Chr17:100659430-101923665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024566
protein coding gene Chr17:92612128-93724267 (-)
PWK/PhJ MGP_PWKPhJ_G0023065
protein coding gene Chr17:88617337-89711897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022876
protein coding gene Chr17:89356462-90483409 (-)
WSB/EiJ MGP_WSBEiJ_G0023386
protein coding gene Chr17:93473091-94592484 (-)



Homology
more
  • Human Ortholog
    NRXN1, neurexin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRXN1, neurexin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Hs.22998, PTHSL2, SCZD17
  • Links
    NCBI Gene ID: 9378
    neXtProt AC: NX_P58400, NX_Q9ULB1
    UniProt: P58400, Q9ULB1

  • Chr Location
    2p16.3; chr2:49918503-51032536 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Nrxn1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024109 Ensembl Gene Model | MGI Sequence Detail 1059441 C57BL/6J ±  kb
    transcript ENSMUST00000161402 Ensembl | MGI Sequence Detail 4953 Not Applicable  
    polypeptide ENSMUSP00000124116 Ensembl | MGI Sequence Detail 1514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 3
      cDNA 68

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915292, MGI:2442437, MGI:2444963
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 26
      Phenotypes 30
    • Earliest
      J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
    • Latest
      J:244911 Zhang M, et al., Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. Genes Dev. 2017 Aug 9;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory