Nrxn1
Gene Detail

Symbol Name ID

Nrxn1 neurexin I MGI:1096391

Synonyms

1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta

Feature Type

protein coding gene

Genetic Map

Chromosome 17

59.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:90033644-91092805 bp, - strand From VEGA annotation of GRCm38   1059162 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21005  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neurexin
Gene Tree: Nrxn1

Human homologs

Human Homolog		NRXN1, neurexin 1
NCBI Gene ID		9378
neXtProt AC		NX_P58400, NX_Q9ULB1
Human Synonyms		Hs.22998, PTHSL2, SCZD17
Human Chr (Location)		2p16.3; chr2:50145643-51259674 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NRXN1

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(7)
 

Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).

 
Human Diseases Modeled Using Mouse Nrxn1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (73 annotations)

Process	adult behavior, angiogenesis, ...
Component	axonal growth cone, cell, ...
Function	acetylcholine receptor binding, calcium channel regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (159)    Tissues (22)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	159

cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) Genomic(3) cDNA(64)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000034567 (Evidence)
Ensembl Gene Model	ENSMUSG00000024109 (Evidence)
Entrez Gene	18189 (Evidence)
UniGene	485930
NIA Mouse Gene Index	U038154
PDB	3BOD, 3MW2
Consensus CDS Project	CCDS57112.1, CCDS57113.1
International Mouse Knockout Project Status	Nrxn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034567	VEGA Gene Model | MGI Sequence Detail	1059162	C57BL/6J
transcript	OTTMUST00000087771	VEGA | MGI Sequence Detail	4545	Not Applicable
polypeptide	OTTMUSP00000047783	VEGA | MGI Sequence Detail	1514	Not Applicable

All sequences(106) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(4602 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR003585	Neurexin/syndecan/glycophorin C
Protein Ontology	PR:000011571	neurexin-1

References

(Earliest) J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
(Latest) J:185327 Laarakker MC, et al., Sex-dependent novelty response in neurexin-1alpha mutant mice. PLoS One. 2012;7(2):e31503
All references(64)

Other accession IDs

MGI:1915292, MGI:2442437, MGI:2444963