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Nrxn1
Gene Detail
 Symbol
Name
ID
Nrxn1
neurexin I
MGI:1096391
Synonyms 1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta
Feature Type protein coding gene
Genetic Map
Chromosome 17
59.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:90033644-91092805 bp, - strand
From VEGA annotation of GRCm38

  1059162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21005  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neurexin
Gene Tree: Nrxn1

Human
homologs
Human Homolog NRXN1, neurexin 1
NCBI Gene ID 9378
neXtProt AC  NX_P58400, NX_Q9ULB1
Human Synonyms  Hs.22998, PTHSL2, SCZD17
Human Chr (Location)  2p16.3; chr2:49918505-51032536 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NRXN1
Alleles
and
phenotypes
All alleles(11) : Targeted(4) Gene trapped(7)
 
Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).
 
Human Diseases Modeled Using Mouse Nrxn1 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process adult behavior, cell adhesion, ...
Component cell, cell junction, ...
Function acetylcholine receptor binding, calcium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (172)    Tissues (30)    Images (32)
Theiler Stages: 23, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 159
cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(67) Genomic(3) cDNA(64)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034567 (Evidence)
Ensembl Gene ModelENSMUSG00000024109 (Evidence)
Entrez Gene18189 (Evidence)
UniGene491332
NIA Mouse Gene IndexU038154
PDB3BOD, 3MW2
Consensus CDS ProjectCCDS57112.1, CCDS57113.1
International Mouse Knockout Project StatusNrxn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034567 VEGA Gene Model | MGI Sequence Detail 1059162 C57BL/6J ±  kb
transcript OTTMUST00000087771 VEGA | MGI Sequence Detail 4545 Not Applicable 
polypeptide OTTMUSP00000047783 VEGA | MGI Sequence Detail 1514 Not Applicable 

For the selected sequences
All sequences(141) RefSeq(38) UniProt(9)
Polymorphisms SNPs within 2kb(6311 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6325)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR027158 Neurexin-1-alpha
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000011571 neurexin-1
References (Earliest) J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
(Latest) J:203721 Grayton HM, et al., Altered social behaviours in neurexin 1alpha knockout mice resemble core symptoms in neurodevelopmental disorders. PLoS One. 2013;8(6):e67114
All references(63)
Other
accession IDs
MGI:1915292, MGI:2442437, MGI:2444963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory