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Nrxn1
Gene Detail
Symbol

Name
ID
Nrxn1
neurexin I
MGI:1096391
Synonyms
1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta
Feature Type
protein coding gene
Genetic Map
Chromosome 17
59.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:90033644-91092805 bp, - strand
From VEGA annotation of GRCm38

  1059162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21005  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NRXN1
Protein SuperFamily: neurexin
Gene Tree: Nrxn1

Human
homologs
NRXN1, neurexin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9378
neXtProt AC: NX_P58400, NX_Q9ULB1

Human Synonyms: Hs.22998, PTHSL2, SCZD17

Human Chr (Location): 2p16.3; chr2:49918505-51032536 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NRXN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).
 
Human Diseases Modeled in Mice Using Nrxn1 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Nrxn1 interacts with 440 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process adult behavior, cell adhesion, ...
Component cell, cell junction, ...
Function acetylcholine receptor binding, calcium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (172)    Tissues (30)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 159
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nrxn1 ; ZFIN nrxn1a    NEW 
Molecular
reagents
All nucleic(68) Genomic(3) cDNA(65)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034567 (Evidence)
Ensembl Gene Model ENSMUSG00000024109 (Evidence)
Entrez Gene 18189 (Evidence)
UniGene 491332
NIA Mouse Gene Index U038154
PDB 3MW2, 3BOD
Consensus CDS Project CCDS57112.1, CCDS57113.1
International Mouse Phenotyping Consortium Status Nrxn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034567 VEGA Gene Model | MGI Sequence Detail 1059162 C57BL/6J ±  kb
transcript OTTMUST00000087771 VEGA | MGI Sequence Detail 4545 Not Applicable 
polypeptide OTTMUSP00000047783 VEGA | MGI Sequence Detail 1514 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(26) UniProt(7)
Polymorphisms
SNPs within 2kb(6311 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6325)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000011571 neurexin-1
References
(Earliest) J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
(Latest) J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
All references(66)
Disease annotation references (3)
Other
accession IDs
MGI:1915292, MGI:2442437, MGI:2444963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory