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Nrxn1 Gene Detail
Summary
  • Symbol
    Nrxn1
  • Name
    neurexin I
  • Synonyms
    1700062G21Rik, 9330127H16Rik, A230068P09Rik, alpha-latrotoxin receptor (calcium-dependent), mKIAA0578, neurexin I alpha, neurexin I alpha, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096391
    NCBI Gene: 18189
  • Gene Overview
    MyGene.info: NRXN1
Location & Maps
more
  • Sequence Map
    Chr17:90033631-91093071 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1059441 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NRXN1, neurexin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRXN1, neurexin 1
    Orthology source: HomoloGene
  • Synonyms
    Hs.22998, PTHSL2, SCZD17
  • Links
    NCBI Gene ID: 9378
    neXtProt AC: NX_P58400, NX_Q9ULB1

  • Chr Location
    2p16.3; chr2:49918505-51032536 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Nrxn1 mouse models; 2 with human NRXN1 associations

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Schizophrenia; SCZD   OMIM: 181500 View 1 model
       Chromosome 2p16.3 Deletion Syndrome   OMIM: 614332
Pitt-Hopkins-Like Syndrome 2; PTHSL2   OMIM: 614325
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034567 VEGA Gene Model | MGI Sequence Detail 1059441 C57BL/6J ±  kb
transcript OTTMUST00000087771 VEGA | MGI Sequence Detail 4953 Not Applicable  
polypeptide OTTMUSP00000047783 VEGA | MGI Sequence Detail 1514 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6227 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 68
    Genomic 3
    cDNA 65

    Microarray probesets 5
Other
Accession IDs
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MGI:1915292, MGI:2442437, MGI:2444963
References
more
  • Summaries
    All 67
    Developmental Gene Expression 7
    Diseases 3
    Gene Ontology 15
    Phenotypes 22
  • Earliest
    J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
  • Latest
    J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory